U4atac minor spliceosomal RNA

U4atac minor spliceosomal RNA

U4atac minor spliceosomal RNA is a ncRNA which is an essential component of the minor U12-type spliceosome complex. The U12-type spliceosome is required for removal of the rarer class of eukaryotic introns (AT-AC, U12-type) cite journal |author= Lorkovic ZJ, Lehner R, Forstner C, Barta A; |title= Evolutionary conservation of minor U12-type spliceosome betweenplants and humans. |journal= RNA |volume= 11 |issue= |pages= 1095–1107 |year= 2005 |pmid=15987817 |doi= 10.1261/rna.2440305] .

U4atac snRNA is proposed to form a base-paired complex with another spliceosomal RNA U6atac via two stem loop regions. These interacting stem loops have been shown to be required for in vivo splicing cite journal |author= Shukla GC, Cole AJ, Dietrich RC, Padgett RA; |title= Domains of human U4atac snRNA required for U12-dependent splicing invivo. |journal= Nucleic Acids Res |volume= 30 |issue= |pages= 4650–4657 |year= 2002 |pmid=12409455 |doi= 10.1093/nar/gkf609] . U4atac also contains an 3' Sm protein binding site which has been shown to be essential for splicing activity . U4atac is the functional analog of U4 spliceosomal RNA in the major U2-type spliceosomal complex .

The Drosophila U4atac snRNA has an additional predicted 3' stem loop terminal to the Sm binding site cite journal |author= Padgett RA, Shukla GC; |title= A revised model for U4atac/U6atac snRNA base pairing. |journal= RNA |volume= 8 |issue= |pages= 125–128 |year= 2002 |pmid=11911359 |doi= 10.1017/S1355838202017156] .

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  • U6atac minor spliceosomal RNA — is a non coding RNA which is an essential component of the minor U12 type spliceosome complex. The U12 type spliceosome is required for removal of the rarer class of eukaryotic introns (AT AC, U12 type) cite journal |author= Lorkovic ZJ, Lehner R …   Wikipedia

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  • Spliceosome — A spliceosome is a complex of specialized RNA and protein subunits that removes introns from a transcribed pre mRNA (hnRNA)segment. This process is generally referred to as splicing. CompositionEach spliceosome is composed of five small nuclear… …   Wikipedia

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