Aromatase inhibitor

Aromatase inhibitor

Aromatase inhibitors (AI) are a class of drugs used in the treatment of breast cancer and ovarian cancer in postmenopausal women that block the aromatase enzyme.

Type I and II

AIs are categorized into two types: [cite journal |author=Mokbel K |title=The evolving role of aromatase inhibitors in breast cancer |journal=Int J Clin Oncol |volume=7 |issue=5 |pages=279–83 |year=2002 |pmid=12402060 |doi=10.1007/s101470200040]
* Irreversible steroidal inhibitors such as exemestane form a permanent bond with the aromatase enzyme complex.
* Non-steroidal inhibitors (such as anastrozole, letrozole) inhibit the enzyme by reversible competition.

Mode of action

Aromatase inhibitors work by inhibiting the action of the enzyme aromatase, which converts androgens into estrogens by a process called aromatization. As breast tissue is stimulated by estrogens, decreasing their production is a way of suppressing recurrence of the breast tumor tissue.



In contrast to pre-menopausal women, in whom most of the estrogen is produced in the ovaries, in post-menopausal women most of the body's estrogen is produced in the adrenal gland from the conversion of androgens. The other main source of estrogen post-menopausally is adipose tissue Fact|date=February 2007. Because some breast cancers respond to estrogen, lowering the estrogen level in post-menopausal women using aromatase inhibitors has been proven to be effective in breast cancer treatment. [Howell A, et al; ATAC Trialists Group. Results of the ATAC (Arimidex, Tamoxifen, Alone or in Combination) trial after completion of 5 years' adjuvant treatment for breast cancer. Lancet 2005 Jan 1-7;365(9453):60-2. PMID 15639680]

Aromatase inhibitors are generally not used to treat breast cancer in "premenopausal" women. Since most of the circulating estrogen is produced by the ovaries, not by conversion of androgens to estrogen, blocking the enzyme aromatase does not significantly decrease the production of estrogen. When aromatase inhibitors are used in premenopausal women, the decrease in estrogen activates the hypothalamus and pituitary axis to increase gonadotropin secretion, which in turn stimulates the ovary to increase androgen production. This counteracts the effect of the aromatase inhibitor.

An ongoing area of clinical research is optimizing adjuvant hormonal therapy in postmenopausal women with breast cancer. Tamoxifen has been standard treatment, however the ATAC trial has shown that clinical results are superior with an AI in postmenopausal women with localized breast cancer that is estrogen receptor positive. Further studies of various AIs are ongoing.


Investigations are ongoing to look for other applications. Researchers are studying aromatase inhibitors to stimulate ovulation (in a manner similar to, but not exactly the same as, clomiphene citrate) or suppress estrogen production, ie in endometriosis. [Attar E, Bulun SE. Aromatase inhibitors: the next generation of therapeutics for endometriosis? Fertil Steril 2006;85:1307-18. PMID 16647373]

AIs have also been used experimentally in the treatment of adolescents whose predicted adult height is low. [cite journal |author=Hero M, Wickman S, Dunkel L |title=Treatment with the aromatase inhibitor letrozole during adolescence increases near-final height in boys with constitutional delay of puberty |journal=Clin Endocrinol (Oxf) |volume=64 |issue=5 |pages=510–3 |year=2006 |pmid=16649968 |doi=10.1111/j.1365-2265.2006.02499.x]

Bodybuilders who take anabolic steroids may also take AIs to prevent the steroids from being converted to estrogen; an increase in estrogen levels has undesirable consequences for a bodybuilder, such as gynecomastia. This is often the case when a natural aromatase inhibitor 4-OHAD [] has itself been inhibited.4-OHAD is a metabolite of testosterone, which can mean 4-OHAD remains inhibited whilst aromatase levels are allowed high.

In one recent study, aromatase inhibitors were found to be no more successful at treating pubertal gynecomastia than a placebo. [cite journal |author=Plourde PV, Reiter EO, Jou HC, Desrochers PE, Rubin SD, Bercu BB, Diamond FB Jr, Backeljauw PF |title=Safety and efficacy of anastrozole for the treatment of pubertal gynecomastia: a randomized, double-blind, placebo-controlled trial |journal=Clin Endocrinol (Oxf)|pmid=15356042]

Aromatase inhibitors have also been shown to reverse age-related declines in testosterone, as well as primary hypogonadism. [cite journal |author=Leder BZ, Rohrer JL, Rubin SD, Gallo J, Longcope C. |title= Effects of aromatase inhibition in elderly men with low or borderline-low serum testosterone levels|journal=Clin Endocrinol (Oxf)|pmid=15001605 ]


Some of the aromatase inhibitors in use include:
* Aminoglutethimide
* Anastrozole (Arimidex)
* Letrozole (Femara)
* Vorozole (Rivizor)
* Exemestane (Aromasin)
* 4-androstene-3,6,17-trione ("6-OXO", marketed as a nutritional supplement for athletes and weight lifters)
* 1,4,6-androstatrien-3,17-dione (ATD)
* Formestane (Lentaron)
* Testolactone (Teslac)
* Fadrozole (Afema)


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