Metaclazepam

Metaclazepam

Systematic (IUPAC) name
7-bromo-5-(2-chlorophenyl)-2-(methoxymethyl)-1-methyl-2,3-dihydro-1H-1,4-benzodiazepine
Clinical data
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	84031-17-4 Y
ATC code	None
PubChem	CID 71272
ChemSpider	64398 Y
UNII	C2N2B1303L Y
Chemical data
Formula	C18H18BrClN2O
Mol. mass	393.705
SMILES	eMolecules & PubChem
InChI InChI=1S/C18H18BrClN2O/c1-22-13(11-23-2)10-21-18(14-5-3-4-6-16(14)20)15-9-12(19)7-8-17(15)22/h3-9,13H,10-11H2,1-2H3 Y Key:WABYCCJHARSRBH-UHFFFAOYSA-N Y
Y(what is this?)  (verify)

Metaclazepam^[1] (marketed under the brand name Talis) is a drug which is a benzodiazepine derivative.^[2][3] It is a relatively selective anxiolytic with less sedative or muscle relaxant properties than other benzodiazepines such as diazepam or bromazepam.^[4] It has an active metabolite N-desmethylmetaclazepam, which is the main metabolite of metaclazepam.^[5] There is no significant difference in metabolism between younger and older individuals.^[6]

Metaclazepam is slightly more effective as an anxiolytic than bromazepam,^[7] or diazepam,^[8] with a 15 mg dose of metaclazepam equivalent to 4 mg of bromazepam.^[9] Metaclazepam can interact with alcohol producing additive sedative-hypnotic effects.^[10][11] Fatigue is a common side effect from metaclazepam at high doses.^[12] Small amounts of metaclazepam as well as its metabolites enter into human breast milk.^[13]

See also

• Benzodiazepine