Afloqualone

Afloqualone

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IUPAC_name = 6-amino-2-(fluoromethyl)-3-(2-methylphenyl)quinazolin-4-one


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CAS_number = 56287-74-2
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PubChem = 2040
ChemSpiderID = 1960
DrugBank =
C=16 | H=14 | F=1 | N=3 | O=1
molecular_weight = 283.3
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Afloqualone (Arofuto) is an analogue of methaqualone developed in the 1980s in Japan. It has sedative and muscle relaxant effects, [Ochiai T, Ishida R. Pharmacological studies on 6-amino-2-fluoromethyl-3-(O-tolyl)-4(3H)-quinazolinone (afloqualone), a new centrally acting muscle relaxant. (II) Effects on the spinal reflex potential and the rigidity. Japanese Journal of Pharmacology. 1982 Jun;32(3):427-38.] and has had some clinical use, although it causes photosensitization as a side effect which can cause skin problems such as dermatitis. [Ishikawa T, Kamide R, Niimura M. Photoleukomelanodermatitis (Kobori) induced by afloqualone. Journal of Dermatology. 1994 Jun;21(6):430-3.]

See also

* Methaqualone
* Diproqualone
* Etaqualone
* Methylmethaqualone
* Mecloqualone
* Mebroqualone
* Cloroqualone

References


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