HLA-A2


HLA-A2

monoisoform
isoformgroup = HLA-A2
polymer_type = MHC Class I, A cell surface antigen


image_source = Rendering of PDB2|2git: α (A*0201 gene product), β2-microglobulin, and HIV peptide.
protein_type = transmembrane receptor/ligand
structure = αβ heterodimer
subunit_genes = HLA-A*02--, β2-microglobulin
alias = HL-A2
isoformCount = 5
subunit1 = allele
nick1 = A2.1
linkout = HAwA
allele1a = 0201
images1 = PDB2|3hla, PDB2|2gj6, PDB2|2git, PDB2|2clr, PDB2|2bsv, PDB2|2c7u, PDB2|2bsu, PDB2|2av1, PDB2|2av7, PDB2|1tvb, PDB2|1tvh, PDB2|1s8d, PDB2|1s9w, PDB2|1s9x, PDB2|1s9y, PDB2|1t1w, PDB2|1t1x, PDB2|1t1y, PDB2|1t1z, PDB2|1t20, PDB2|1t21, PDB2|1t22, PDB2|1qse, PDB2|1qr1, PDB2|1qrn, PDB2|1p7q, PDB2|1jf1, PDB2|1jht, PDB2|1i1f, PDB2|1i1y, PDB2|1i4f, PDB2|1i7r, PDB2|1i7t, PDB2|1i7u, PDB2|1im3, PDB2|1akj, PDB2|1ao7, PDB2|1b0g, PDB2|1b0r, PDB2|1bd2, PDB2|1duy, PDB2|1duz, PDB2|1eey, PDB2|1eez, PDB2|1hhg, PDB2|1hhh, PDB2|1hhi, PDB2|1hhj, PDB2|1hhk, PDB2|1hla
nick2 = A2.2F
allele2a = 0202
nick3 = A2.3, A203
allele3a = 0203
nick4 = A2.2Y
allele4a = 0205
nick5 = A2.4a
allele5a = 0206
rareIsoforms = 3
rnick1 = A2.4
rallele1a = 0204
rnick2 = A2.4b
rallele2a = 0207
rnick3 = A2.5
rallele3a = 0211

HLA-A2 (A2) is a human leukocyte antigen "serotype" within HLA-A "A" serotype group. The serotype is determined by the antibody recognition of α2 subset of HLA-A α-chains. For A2, the alpha "A" chain are encoded by the HLA-A*02 allele group and the β-chain are encoded by B2M .cite journal |author=Arce-Gomez B, Jones EA, Barnstable CJ, Solomon E, Bodmer WF |title=The genetic control of HLA-A and B antigens in somatic cell hybrids: requirement for beta2 microglobulin |journal=Tissue Antigens |volume=11 |issue=2 |pages=96–112 |year=1978 |month=February |pmid=77067 |doi= |url=] A2 and A*02 are almost synonymous in meaning. A2 is more common in Northern Asia and North America than elsewhere, and it is part of a several long haplotypes.

The serotype identifies the gene products of many HLA-A*02 alleles, including HLA-A*0201, *0202, *0203, *0206, and *0207 gene products. A*02 is globally common, but A*0201 is at high frequencies in Northern Asia and North America. A2 is the most diverse serotype, showing diversity in Eastern Africa and Southwest Asia. While the frequency of A*0201 in Northern Asia is high, its diversity is limited to A*0201 the less common Asian variants A*0203, A*0206.

erotype

Serotype
color1=#B0E0FF |color2=#E0F0FF | color3 = #F0F8FF
gene = A
type = 2
types = 1
allelegroup = 02
alleles = 7
allele1 = 01 |type1alle1freq = 98 |N1 = 6315
allele2 = 02 |type1alle2freq = 81 |N2 = 859
allele3 = 03 |type1alle3freq = 64 |N3 = 472
allele4 = 05 |type1alle4freq = 81 |N4 = 462
allele5 = 06 |type1alle5freq = 68 |N5 = 636
allele6 = 07 |type1alle6freq = 80 |N6 = 135
allele7 = 11 |type1alle7freq = 74 |N7 = 228

The serotyping for the most abundant A*02 alleles is good. For A*0203, A*0206, A*0207 serotyping is borderline useful. There is a separate serotyping for A203 and A210. There are over 125 alleles identified (mostly by sequence homology) as being A2, of those 8 are nulls, and a large majority have unknown serotypes.

Disease Associations

A2 Associated with spontaneous abortion in A2+/A [other] phenotypic childrencite journal |author=Komlos L, Klein T, Korostishevsky M |title=HLA-A2 class I antigens in couples with recurrent spontaneous abortions |journal=Int. J. Immunogenet. |volume=34 |issue=4 |pages=241–6 |year=2007 |pmid=17627758 |doi=10.1111/j.1744-313X.2007.00682.x |issn=]

By haplotype

A*02:Cw*16 is associated with increased higher viral load in HIVcite journal | author = Tang J, Tang S, Lobashevsky E, Myracle A, Fideli U, Aldrovandi G, Allen S, Musonda R, Kaslow R | title = Favorable and unfavorable HLA class I alleles and haplotypes in Zambians predominantly infected with clade C human immunodeficiency virus type 1. | journal = J Virol | volume = 76 | issue = 16 | pages = 8276–84 | year = 2002 | pmid = 12134033 | doi = 10.1128/JVI.76.16.8276-8284.2002]


Alleles

AlleleFreq
Placement = right
Allele = A*0201
Freq1 = 54.5 | People1 = Mexico Sonora Seri
Freq2 = 43.6 | People2 = USA Arizona Pima
Freq3 = 37.8 | People3 = USA New Mexico Canoncito …
Freq4 = 34.4 | People4 = Finland
Freq5 = 34.1 | People5 = Mexico Mestizos
Freq6 = 31.0 | People6 = Georgia Tibilisi Georgian…
Freq7 = 30.0 | People7 = Bulgaria
Freq8 = 30.0 | People8 = Philippines Ivatan
Freq9 = 29.9 | People9 = Spain Catalonia Girona
Freq10 = 29.7 | People10 = USA South Dakota Lakota S…
Freq11 = 29.3 | People11 = Portugal North
Freq12 = 28.9 | People12 = Italy North pop 1
Freq13 = 28.4 | People13 = Mexico Zaptotec Oaxaca
Freq14 = 28.0 | People14 = Italy Bergamo
Freq15 = 27.4 | People15 = Czech Republic
Freq16 = 27.4 | People16 = Ireland Northern
Freq17 = 27.2 | People17 = USA Caucasian (2)
Freq18 = 27.0 | People18 = Spain Basque Gipuzkoa Pro…
Freq19 = 26.6 | People19 = Belgium
Freq20 = 26.3 | People20 = Croatia
Freq21 = 26.1 | People21 = Australia New South Wales
Freq22 = 26.0 | People22 = Portugal Centre
Freq23 = 25.7 | People23 = Turkey (1)
Freq24 = 25.0 | People24 = Mexico Chihuahua State Ta…
Freq25 = 25.0 | People25 = Romanian
Freq26 = 24.6 | People26 = Ireland South
Freq27 = 22.3 | People27 = Mexico Guadalajara Mestiz…
Freq28 = 21.8 | People28 = China Tibet
Freq29 = 21.7 | People29 = USA North American Native…
Freq30 = 21.7 | People30 = USA South Texas Hispanics
Freq31 = 21.6 | People31 = Oman
Freq32 = 21.6 | People32 = Venezuela Perja Mountain …
Freq33 = 21.3 | People33 = Georgia Svaneti Svans
Freq34 = 20.8 | People34 = Brazil Terena
Freq35 = 20.2 | People35 = Iran Baloch
Freq36 = 20.0 | People36 = Japan Ainu Hokkaido
Freq37 = 19.2 | People37 = Brazil
Freq38 = 18.7 | People38 = China Beijing
Freq39 = 18.4 | People39 = Uganda Kampala
Freq40 = 17.8 | People40 = Morocco Nador Berber
Freq41 = 17.5 | People41 = Australia Indig. Cape Yor…
Freq42 = 17.5 | People42 = Tunisia
Freq43 = 17.3 | People43 = Sudanese
Freq44 = 16.5 | People44 = South Korea (3)
Freq45 = 14.3 | People45 = Mongolia Buriat
Freq46 = 13.8 | People46 = Burkina Faso Rimaibe
Freq47 = 13.4 | People47 = Jordan Amman
Freq48 = 12.8 | People48 = Zambia Lusaka
Freq49 = 12.1 | People49 = USA African Americans (3)
Freq50 = 11.6 | People50 = Japan (3)
Freq51 = 10.7 | People51 = India Tamil Nadu Nadar
Freq52 = 10.2 | People52 = Japan Okinawa Ryukuan
Freq53 = 9.1 | People53 = Zimbabwe Harare Shona
Freq54 = 9.0 | People54 = Ecuador Cayapa
Freq55 = 8.7 | People55 = Kenya
Freq56 = 8.3 | People56 = Georgia Tibilisi Kurds
Freq57 = 8.3 | People57 = Mali Bandiagara
Freq58 = 8.1 | People58 = Senegal Niokholo Mandenka
Freq59 = 7.1 | People59 = Cameroon Yaounde
Freq60 = 6.5 | People60 = Singapore Riau Malay
Freq61 = 5.8 | People61 = India North Hindus
Freq62 = 5.5 | People62 = Taiwan Hakka
Freq63 = 5.5 | People63 = Taiwan Pazeh
Freq64 = 5.3 | People64 = China South Han
Freq65 = 5.1 | People65 = Burkina Faso Fulani
Freq66 = 4.9 | People66 = Sri Lanka Colombo Sinhale…
Freq67 = 4.6 | People67 = China Guangxi Maonan
Freq68 = 4.0 | People68 = Singapore Javanese Indone…
Freq69 = 3.9 | People69 = Taiwan Paiwan
Freq70 = 3.4 | People70 = India Andhra Pradesh Goll…
Freq71 = 3.1 | People71 = Singapore Thai
Freq72 = 3.0 | People72 = Taiwan Rukai
Freq73 = 2.9 | People73 = Taiwan Tsou
Freq74 = 2.8 | People74 = Pakistan Karachi Parsi
Freq75 = 2.6 | People75 = Taiwan Ami
Freq76 = 2.5 | People76 = South Africian Natal Zulu
Freq77 = 2.4 | People77 = New Caledonia
Freq78 = 2.4 | People78 = USA Alaska Yupik Natives
Freq79 = 2.1 | People79 = PNG Wanigela
Freq80 = 2.0 | People80 = Taiwan Puyuma
Freq81 = 2.0 | People81 = Taiwan Tao
Freq82 = 1.9 | People82 = India Mumbai Marathas
Freq83 = 1.8 | People83 = Thailand
Freq84 = 1.0 | People84 = South Africa Natal Tamil
AlleleFreq
Placement = left
Allele = A*0202
Freq1 = 10.4 | People1 = Cameroon Bamileke
Freq2 = 9.1 | People2 = Senegal Niokholo Mandenka
Freq3 = 8.2 | People3 = Cameroon Yaounde
Freq4 = 7.6 | People4 = Mali Bandiagara
Freq5 = 6.2 | People5 = Guinea Bissau
Freq6 = 6.0 | People6 = Cameroon Beti
Freq7 = 5.3 | People7 = Burkina Faso Rimaibe
Freq8 = 4.9 | People8 = Kenya
Freq9 = 3.8 | People9 = Georgia Svaneti Svans
Freq10 = 3.7 | People10 = USA African Americans (2)
Freq11 = 3.6 | People11 = Zimbabwe Harare Shona
Freq12 = 3.5 | People12 = South Africian Natal Zulu
Freq13 = 3.4 | People13 = Uganda Kampala
Freq14 = 2.4 | People14 = Saudi Arabia Guraiat and …
Freq15 = 2.3 | People15 = Pakistan Brahui
Freq16 = 2.3 | People16 = Zambia Lusaka
Freq17 = 2.0 | People17 = Israel Arab Druse
Freq18 = 1.8 | People18 = Sudanese
Freq19 = 1.7 | People19 = India North Delhi
Freq20 = 1.7 | People20 = Pakistan Karachi Parsi
Freq21 = 1.4 | People21 = China Qinghai Hui
Freq22 = 1.1 | People22 = Portugal North
Freq23 = 1.0 | People23 = Georgia Tibilisi Georgian…
Freq24 = 1.0 | People24 = Tunisia
AlleleFreq
Placement = left
Allele = A*0203
Freq1 = 17.6 | People1 = China Guangxi Maonan
Freq2 = 15.2 | People2 = China Yunnan Lisu
Freq3 = 12.2 | People3 = Thailand Northeast
Freq4 = 10.8 | People4 = China South Han
Freq5 = 9.8 | People5 = China Guangzhou
Freq6 = 9.0 | People6 = Singapore Javanese Indone…
Freq7 = 8.2 | People7 = China Yunnan Nu
Freq8 = 7.7 | People8 = Thailand
Freq9 = 6.4 | People9 = Taiwan Minnan pop 1
Freq10 = 6.0 | People10 = Taiwan Puyuma
Freq11 = 5.9 | People11 = Taiwan Siraya
Freq12 = 5.2 | People12 = Singapore Riau Malay
Freq13 = 5.0 | People13 = India Khandesh Pawra
Freq14 = 5.0 | People14 = India West Bhils
Freq15 = 4.5 | People15 = Taiwan Pazeh
Freq16 = 4.2 | People16 = USA Asian
Freq17 = 3.7 | People17 = India Mumbai Marathas
Freq18 = 3.6 | People18 = Taiwan Hakka
Freq19 = 2.4 | People19 = China North Han
Freq20 = 2.4 | People20 = Sri Lanka Colombo Sinhale…
Freq21 = 2.3 | People21 = China Qinghai Hui
Freq22 = 1.1 | People22 = Burkina Faso Rimaibe
Freq23 = 1.0 | People23 = Taiwan Saisiat
AlleleFreq
Placement = right
Allele = A*0205
Freq1 = 9.2 | People1 = Burkina Faso Fulani
Freq2 = 8.7 | People2 = Kenya Nandi
Freq3 = 6.5 | People3 = Sudanese
Freq4 = 6.1 | People4 = Saudi Arabia Guraiat and …
Freq5 = 5.8 | People5 = Italy North (1)
Freq6 = 5.5 | People6 = South Africian Natal Zulu
Freq7 = 5.0 | People7 = Cameroon Pygmy Baka
Freq8 = 5.0 | People8 = Georgia Tibilisi Kurds
Freq9 = 4.3 | People9 = Burkina Faso Rimaibe
Freq10 = 4.0 | People10 = Israel Arab Druse
Freq11 = 3.8 | People11 = Cameroon Sawa
Freq12 = 3.5 | People12 = Turkey (1)
Freq13 = 3.2 | People13 = Mongolia Buriat
Freq14 = 3.1 | People14 = Zimbabwe Harare Shona
Freq15 = 3.0 | People15 = India New Delhi
Freq16 = 3.0 | People16 = USA African America
Freq17 = 2.7 | People17 = Bulgaria
Freq18 = 2.6 | People18 = Cameroon Bamileke
Freq19 = 2.6 | People19 = Kenya Luo
Freq20 = 2.5 | People20 = Pakistan Sindhi
Freq21 = 2.5 | People21 = Tunisia
Freq22 = 2.4 | People22 = Cuban Mulatto
Freq23 = 2.4 | People23 = Czech Republic
Freq24 = 2.3 | People24 = Spain Catalonia Girona
Freq25 = 2.2 | People25 = Cameroon Yaounde
Freq26 = 2.2 | People26 = Mali Bandiagara
Freq27 = 2.2 | People27 = Uganda Kampala
Freq28 = 2.1 | People28 = Italy Bergamo
Freq29 = 2.1 | People29 = Oman
Freq30 = 1.7 | People30 = USA African Americans (2)
Freq31 = 1.4 | People31 = China North Han
Freq32 = 1.4 | People32 = Georgia Tibilisi Georgian…
Freq33 = 1.4 | People33 = Kenya
Freq34 = 1.2 | People34 = Ireland Northern
Freq35 = 1.1 | People35 = Cameroon Beti
Freq36 = 1.1 | People36 = India North Delhi
Freq37 = 1.1 | People37 = Senegal Niokholo Mandenka
Freq38 = 1.1 | People38 = USA Caucasians (3)
Freq39 = 1.0 | People39 = India North Hindus
Freq40 = 1.0 | People40 = Mexico Mixtec Oaxaca
Freq41 = 1.0 | People41 = Portugal Centre
Freq42 = 1.0 | People42 = Spain Basque Gipuzkoa Pro…

AlleleFreq
Placement = left
Allele = A*0206
Freq1 = 34.9 | People1 = Mexico Mixe Oaxaca
Freq2 = 26.1 | People2 = Mexico Zaptotec Oaxaca
Freq3 = 21.6 | People3 = Mexico Mixtec Oaxaca
Freq4 = 21.6 | People4 = Pakistan Kalash
Freq5 = 20.0 | People5 = Japan Ainu Hokkaido
Freq6 = 18.3 | People6 = Japan Okinawa Ryukuan
Freq7 = 16.5 | People7 = USA Alaska Yupik Natives
Freq8 = 14.3 | People8 = USA Hawaii Okinawa
Freq9 = 13.0 | People9 = American Samoa
Freq10 = 12.5 | People10 = Mexico Chihuahua State Ta…
Freq11 = 12.0 | People11 = Taiwan Puyuma
Freq12 = 10.5 | People12 = USA South Dakota Lakota S…
Freq13 = 9.4 | People13 = Taiwan Atayal
Freq14 = 8.7 | People14 = Japan pop3
Freq15 = 8.4 | People15 = Japan pop5
Freq16 = 7.7 | People16 = India North Delhi
Freq17 = 7.7 | People17 = Japan Central
Freq18 = 7.6 | People18 = USA Arizona Pima
Freq19 = 7.4 | People19 = Taiwan Bunun
Freq20 = 7.3 | People20 = USA South Texas Hispanics
Freq21 = 7.2 | People21 = USA North American Native…
Freq22 = 7.1 | People22 = China North Han
Freq23 = 7.1 | People23 = South Korea pop 3
Freq24 = 6.9 | People24 = Russia Tuva pop 2
Freq25 = 6.1 | People25 = Mexico Mestizos
Freq26 = 6.0 | People26 = Pakistan Burusho
Freq27 = 5.5 | People27 = Taiwan Taroko
Freq28 = 5.2 | People28 = Singapore Chinese Han
Freq29 = 5.0 | People29 = USA Asian
Freq30 = 4.9 | People30 = USA New Mexico Canoncito …
Freq31 = 4.8 | People31 = China Beijing
Freq32 = 4.7 | People32 = China Beijing Shijiazhuan…
Freq33 = 4.7 | People33 = Hong Kong Chinese
Freq34 = 4.6 | People34 = China Guangxi Maonan
Freq35 = 4.3 | People35 = Mongolia Buriat
Freq36 = 4.0 | People36 = China Guangzhou
Freq37 = 4.0 | People37 = Philippines Ivatan
Freq38 = 4.0 | People38 = Singapore Chinese
Freq39 = 3.6 | People39 = Taiwan Pazeh
Freq40 = 3.5 | People40 = China South Han
Freq41 = 3.3 | People41 = Taiwan Thao
Freq42 = 3.2 | People42 = Pakistan Sindhi
Freq43 = 3.2 | People43 = USA Hispanic
Freq44 = 3.1 | People44 = Pakistan Pathan
Freq45 = 3.0 | People45 = India New Delhi
Freq46 = 3.0 | People46 = Taiwan Rukai
Freq47 = 2.9 | People47 = India North Hindus
Freq48 = 2.9 | People48 = Taiwan Minnan pop 1
Freq49 = 2.9 | People49 = Taiwan Paiwan
Freq50 = 2.8 | People50 = India Andhra Pradesh Goll…
Freq51 = 2.7 | People51 = Taiwan Hakka
Freq52 = 2.6 | People52 = Papua New Guinea Eastern …
Freq53 = 2.5 | People53 = Thailand
Freq54 = 2.4 | People54 = Sri Lanka Colombo Sinhale…
Freq55 = 2.3 | People55 = Pakistan Brahui
Freq56 = 2.1 | People56 = Papua New Guinea Wanigela
Freq57 = 2.0 | People57 = Singapore Javanese Indone…
Freq58 = 2.0 | People58 = Singapore Riau Malay
Freq59 = 2.0 | People59 = Singapore Thai
Freq60 = 2.0 | People60 = Taiwan Saisiat
Freq61 = 2.0 | People61 = Taiwan Siraya
Freq62 = 1.6 | People62 = Pakistan Baloch
Freq63 = 1.5 | People63 = Taiwan Ami
Freq64 = 1.2 | People64 = Zambia Lusaka
Freq65 = 1.1 | People65 = Iran Baloch
Freq66 = 1.1 | People66 = Pakistan Karachi Parsi
AlleleFreq
Placement = left
Allele = A*0207
Freq1 = 15.7 | People1 = Thailand Northeast
Freq2 = 13.4 | People2 = China Guangxi Maonan
Freq3 = 13.1 | People3 = Hong Kong Chinese
Freq4 = 13.1 | People4 = Singapore Chinese
Freq5 = 12.2 | People5 = Singapore Thai
Freq6 = 11.6 | People6 = Singapore Chinese Han
Freq7 = 11.3 | People7 = Taiwan Minnan pop 1
Freq8 = 10.9 | People8 = Thailand
Freq9 = 9.4 | People9 = China South Han
Freq10 = 9.3 | People10 = China Guangzhou
Freq11 = 8.2 | People11 = China Yunnan Nu
Freq12 = 8.2 | People12 = Taiwan Hakka
Freq13 = 6.9 | People13 = Taiwan Siraya
Freq14 = 6.7 | People14 = China Beijing
Freq15 = 6.6 | People15 = USA Asian
Freq16 = 6.4 | People16 = Taiwan Pazeh
Freq17 = 4.3 | People17 = China North Han
Freq18 = 3.6 | People18 = China Qinghai Hui
Freq19 = 3.4 | People19 = Japan (3)
Freq20 = 3.0 | People20 = South Korea (3)
Freq21 = 2.5 | People21 = China Inner Mongolia
Freq22 = 2.2 | People22 = China Yunnan Lisu
Freq23 = 2.1 | People23 = Mongolia Buriat
Freq24 = 2.0 | People24 = Singapore Riau Malay
Freq25 = 1.7 | People25 = Taiwan Thao
Freq26 = 1.6 | People26 = China Tibet Autonomous Re…
Freq27 = 1.6 | People27 = Russia Tuva pop 2
Freq28 = 1.4 | People28 = USA Hawaii Okinawa
Freq29 = 1.0 | People29 = Burkina Faso Fulani
Freq30 = 1.0 | People30 = Japan Ainu Hokkaido
Freq31 = 1.0 | People31 = Singapore Javanese Indone…
AlleleFreq
Placement = right
Allele = A*0211
Freq1 = 16.0 | People1 = India Khandesh Pawra
Freq2 = 13.0 | People2 = South Africa Natal Tamil
Freq3 = 9.7 | People3 = India Andhra Pradesh Goll…
Freq4 = 8.6 | People4 = India Mumbai Marathas
Freq5 = 7.4 | People5 = Sri Lanka Colombo Sinhale…
Freq6 = 6.7 | People6 = India North Hindus
Freq7 = 4.8 | People7 = Ecuador Cayapa
Freq8 = 4.0 | People8 = India West Bhils
Freq9 = 2.5 | People9 = Pakistan Sindhi
Freq10 = 2.3 | People10 = Pakistan Brahui
Freq11 = 2.0 | People11 = Pakistan Pathan
Freq12 = 2.0 | People12 = Singapore Javanese Indone…
Freq13 = 1.7 | People13 = India North Delhi
Freq14 = 1.6 | People14 = Pakistan Baloch
Freq15 = 1.2 | People15 = Singapore Riau Malay
Freq16 = 1.1 | People16 = Iran Baloch
Freq17 = 1.1 | People17 = Pakistan Burusho

A2-B Haplotypes

A2-B7 (Node in Netherlands)A2-B5
*A2-B51
*A2-B52A2-B8
A2-B13
A2-B14
*A2-B64
*A2-B65A2-B15
*A2-B62
*A2-B63
*A2-B70,71,75,76
*A2-B46 (Node in Southern China, may be most abundant haplotype)A2-B16
*A2-B44
*A2-B45A2-B18
A2-B27
A2-B35
A2-B37 A2-B39 (Node in North American Amerinds)
A2-B40

*A2-B60
*A2-B61
A2-B46

A2-Cw5-B44

A2-Cw5-B44 is the multi-serotype designation for the haplotype HLA-A*0201:C*0501:B*4402, the class I portion, of an ancetral haplotype (A2-B44-DR4-DQ8). The full haplotype is (for relative distances see Human leukocyte antigens:

A*0201 : C*0501 : B*4402 : DRB1*0401 : DQA1*0301 : DQB1*0302

Another haplotype that is more common in Central Europe is the (A2-B44-DR7-DQ2)

A*0201 : C*0501 : B*4402 : DRB1*0701 : DQA1*0201 : DQB1*0202

Over northwestern Europe A2-B44 shows a single common ancestor which contributedthe Cw5 allele to the haplotype. The haplotype appears to have been introduced early in European prehistoric period, frequencies of the haplotype generally correlate with A1-Cw7-B8 and A2-B7. The haplotype is considerably more equilibrated relative to A1-B8 and a possible reason is gene flow from iberia or the east with related haplotypes after initial migrations.

References


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  • HLA-A — (HLA A), abreviatura de antígeno leucocitario humano A. Véase antígeno leucocitario humano. Diccionario Mosby Medicina, Enfermería y Ciencias de la Salud, Ediciones Hancourt, S.A. 1999 …   Diccionario médico

  • HLA-B — (HLA B), abreviatura de antígeno leucocitario humano B. Véase antígeno leucocitario humano. Diccionario Mosby Medicina, Enfermería y Ciencias de la Salud, Ediciones Hancourt, S.A. 1999 …   Diccionario médico

  • HLA-D — Abreviatura de antígeno leucocitario humano D. Véase antígeno leucocitario humano. Diccionario Mosby Medicina, Enfermería y Ciencias de la Salud, Ediciones Hancourt, S.A. 1999 …   Diccionario médico


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