Acute motor axonal neuropathy

Acute motor axonal neuropathy

Acute motor axonal neuropathy (AMAN) is a variant of Guillain Barre Syndrome. It is characterized by acute paralysis, loss of reflexes without sensory loss. Pathologically, one can observe motor axonal degeneration with antibody mediated attacks of motor nerve and nodes of Ranvier.


AMAN, also known as Chinese Paralytic Syndrome [Biller J. Practical Neurology, Second Edition. Lippincott Williams and Wilkins; 2002:Pg 361] , was first described by a group of Hopkins and Penn Neurologists in collaboration with Neurologists from Second Teaching Hospital of Hebei Medical School and Beijing Children Hospital [McKhann GM, Cornblath DR, Ho T, Li CY, Bai AY, Wu HS, Yei QF, Zhang WC, Zhaori Z, Jiang Z, et al. Clinical and electrophysiological aspects of acute paralytic disease of children and young adults in northern China. Lancet 1991;338:593-7] . In 1991, Drs Guy Mckhann, Jack Griffin, Dave Cornblath and Tony Ho from Johns Hopkins University and Dr. Arthur Asbury from University of Pennsylvania visited China to study a mysterious epidemic of paralytic syndrome occurring in Northern China. Every summer, hundreds of children from rural China develop acute paralysis and respiratory failure. Hospitals were overwhelm with number of cases and often ran out the respirators and hospital beds. Examination of these children showed that many of them have acute flaccid paralysis, areflexia but with little or no sensory loss. Electrophysiology testing of these children showed motor axonal loss with occasional conduction block and little or no demyelinating features and normal sensory potentials. In contrast, the common form of Guillain Barre Syndrome in the West often present with sensory finding and demyelinating features on electrophysiology testing and is more common in adults. Later, several autopsies confirmed the focus of the immune attack was at the motor axolemma especially around the nodes of Ranvier. These cases showed deposition of antibody and complement along the motor axolemma and associated macrophage infiltration [Griffin JW, Li CY, Ho TW, Xue P, Macko C, Gao CY, Yang C, Tian M, Mishu B, Cornblath DR, et al. Guillain-Barré syndrome in northern China: The spectrum of neuropathological changes in clinically defined cases. Brain 1995;118:577-95] .

A link to Campylobacter jejuni was suspected when a young girl was admitted to Second Teaching Hospital (STH). She was studying in the city, however, she was called back to the village when many of family Chicken came down with a mysterious disease. She was tasked of feeding these chicken with medicine. Soon, she developed acute paralysis and respiratory failure. Upon hearing the story, Dr. Li Chun yun of STH and Dr. Ho of Hopkins send a team of investigator to the village to study the situation. They found that chicken from the village were paralyzed like the human with similar motor axonal pathology. With the help of Dr. Nachamkin of University of Pennsylvania, the team was successful culturing Campylobacter jejuni from Chicken feces. When the C. jejni was fed back to the chicken, many of the chicken developed acute paralysis. An epidemiology study examining the sera form patients who developed AMAN showed many of them has increase titeres to C. jejuni and Anti-GD1a antibody [Ho TW, Mishu B, Li CY, Gao CY, Cornblath DR, Griffin JW, Asbury AK, Blaser MJ, McKhann GM. Guillain-Barré syndrome in northern China. Relationship to Campylobacter jejuni infection and anti-glycolipid antibodies. Brain 1995;118:597-605.] .

Presentation and Diagnosis

It typically presents as a progressive flaccid symmetric paralysis with areflexia, often causing respiratory failure. Electromyographic studies and nerve conduction studies (EMG/NCS) show normal motor conduction velocity and latency with decreased amplitude of compound muscle action potentials [CMAP] . F-waves and sensory-nerve action potentials are often normal in this dreaded illness. Pathologically, it is a noninflammatory axonopathy without demyelination. [Biller J. Practical Neurology, Second Edition. Lippincott Williams and Wilkins; 2002:Pg 361]


Wikimedia Foundation. 2010.

Look at other dictionaries:

  • acute motor axonal neuropathy — (AMAN) a subtype of Guillain Barrй syndrome seen in China, caused by infection with Campylobacter jejuni …   Medical dictionary

  • acute motor-sensory axonal neuropathy — a rare subtype of Guillain Barrй syndrome involving primarily large sensory nerve fibers in the limbs, with paresthesias and weakness but not paralysis …   Medical dictionary

  • Neuropathy — Any and all disease or malfunction of the nerves. * * * 1. A classical term for any disorder affecting any segment of the nervous system. 2. In contemporary usage, a disease involving the cranial nerves or the peripheral or autonomic nervous …   Medical dictionary

  • Peripheral neuropathy — Neuropathy redirects here. For other uses, see Neuropathy (disambiguation). Not to be confused with Nephropathy. Peripheral neuropathy Classification and external resources …   Wikipedia

  • Optic neuropathy — Classification and external resources ICD 10 H46 The optic nerve contains axons of nerve cells that emerge from the retina, leave the eye at the optic disc, and go to the visual cortex where input from the eye is processed into vision. There are… …   Wikipedia

  • AMAN — acute motor axonal neuropathy …   Medical dictionary

  • Guillain–Barré syndrome — Guillain Barré syndrome Classification and external resources ICD 10 G61.0 ICD 9 357.0 …   Wikipedia

  • Guillain-Barré syndrome — Infobox Disease Name = Guillain Barré syndrome Caption = DiseasesDB = 5465 ICD10 = ICD10|G|61|0|g|60 ICD9 = ICD9|357.0 ICDO = OMIM = 139393 MedlinePlus = 000684 eMedicineSubj = emerg eMedicineTopic = 222 eMedicine mult = eMedicine2|neuro|7… …   Wikipedia

  • Guillain-Barrй syndrome — (GBS) rapidly progressive ascending motor neuron paralysis of unknown etiology, frequently seen after an enteric or respiratory infection. An autoimmune mechanism following viral infection has been postulated. It begins with paresthesias of the… …   Medical dictionary

  • Anti-ganglioside antibodies — AutoAbBox Autoantigen = ganglioside OneIsoform = CommentOneIsoform Answer only if true OneGene = OneOrgan = OneTissue = OneCell = OneAlso = OneDisease = OneIgClass = OneIgGSubclass = OneHLA1 = OneHLA2 = OneHLA3 = OneTCellRestr = SharedInfo = Yes… …   Wikipedia