Naftifine

Naftifine

Systematic (IUPAC) name
(2E)-N-methyl-N-(1-naphthylmethyl)-3-phenylprop-2-en-1-amine
Clinical data
Trade names	Naftin
AHFS/Drugs.com	monograph
MedlinePlus	a688020
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	65472-88-0 Y
ATC code	D01AE22
PubChem	CID 47641
DrugBank	DB00735
ChemSpider	66071 N
UNII	4FB1TON47A N
ChEMBL	CHEMBL626 N
Chemical data
Formula	C21H21N
Mol. mass	287.398 g/mol
N(what is this?)  (verify)

Naftifine (brand name Naftin) is an allylamine antifungal drug for the topical treatment of tinea pedis, tinea cruris, and tinea corporis (fungal infections).

Its precise mechanism of action is unknown, but may involve selectively blocking sterol biosynthesis via inhibition of the squalene 2,3-epoxidase enzyme.^[1][2] The half-life is approximate 2–3 days.^[2][3] The metabolites are excreted in the urine and feces.^[3][4]

References

1. ^ Robertson Dirk B, Maibach Howard I, "Chapter 61. Dermatologic Pharmacology" (Chapter). Bertram G. Katzung, Susan B. Masters, Anthony J. Trevor: Basic & Clinical Pharmacology, 11e: http://www.accesspharmacy.com/content.aspx?aID=4517257.
2. ^ ^{a b} Micromedex DRUGDEX Drug Point: Naftifine Hydrochloride. Accessed at http://www.thomsonhc.com/hcs/librarian/ND_T/HCS/ND_PR/Main/CS/7ED8A6/DUPLICATIONSHIELDSYNC/89971B/ND_PG/PRIH/ND_B/HCS/SBK/2/ND_P/Main/PFActionId/hcs.common.RetrieveDocumentCommon/DocId/390170/ContentSetId/100/SearchTerm/naftifine/SearchOption/BeginWith#secN10184, February 18, 2010.
3. ^ ^{a b} UptoDate Inc: Naftifine: Drug information. Accessed at http://www.utdol.com/online/content/topic.do?topicKey=drug_l_z/174337&selectedTitle=1~8&source=search_result#F199214, February 18, 2010.
4. ^ AccessPharmacy: Drug Monographs: Naftifine. Accessed at http://www.accesspharmacy.com/drugContentPopup.aspx?mid=6620&section=10, February 18, 2010.

This dermatologic drug article is a stub. You can help Wikipedia by expanding it.v · Categories: Antifungals for dermatologic use Naphthalenes Alkenes Dermatologic drug stubs Wikimedia Foundation. 2010. Игры ⚽ Нужно сделать НИР? Bernard Purdie (footballer) Benjamin Delmas Look at other dictionaries: naftifine hydrochloride — A broad spectrum antifungal agent used in the topical treatment of tinea infections. * * * naf·ti·fine hy·dro·chlo·ride (nafґtĭ fēn) [USP] a broad spectrum antifungal agent, chemically related to allylamines, applied topically to the… …   Medical dictionary Butenafine — Systematic (IUPAC) name [(4 tert butylphenyl)methyl](methyl)(naphthalen 1 ylmethyl)amine Clinical data Trade names …   Wikipedia Salicylic acid — Salicylic acid …   Wikipedia Pentamidine — Systematic (IUPAC) name 4,4 [pentane 1,5 diylbis(ox …   Wikipedia Antifungal drug — An antifungal drug is medication used to treat fungal infections such as athlete s foot, ringworm, candidiasis (thrush), serious systemic infections such as cryptococcal meningitis, and others. Such drugs are usually obtained by a doctor s… …   Wikipedia Itraconazole — Systematic (IUPAC) name (2R,4S) rel 1 (butan 2 yl) 4 {4 [4 (4 {[(2R,4S) 2 (2,4 dichlorophenyl) 2 (1H 1,2,4 triazol 1 ylmethyl) 1,3 dioxolan 4 yl]methoxy}phenyl)piperazin 1 yl]phenyl} 4,5 dihydro 1H 1,2,4 …   Wikipedia Tea tree oil — (Melaleuca Oil) Tea tree oil, or melaleuca oil, is a pale yellow colour to nearly clear essential oil with a fresh camphoraceous odor.[1] It is taken from the leaves of the …   Wikipedia Nystatin — Systematic (IUPAC) name (1S,3R,4R,7R,9R,11R,15S,16R,17R,18S,19E,21E, 25E,27E,29E,31E,33R,35S,36R,37S) 33 [(3 amino 3 …   Wikipedia Amphotericin B — Systematic (IUPAC) name (1R,3S,5R,6R,9 …   Wikipedia Ketoconazole — Systematic (IUPAC) name 1 [4 (4 {[(2R,4 …   Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”