Epalrestat

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ImageFile=epalrestat.pngImageSize=
IUPACName=2- [(5Z)-5- [(E)-3-cyclohexyl-2-methylprop-2-enylidene] - 4-oxo-2-thioxo-3-thiazolidinyl] acetic acid
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Section1= Chembox Identifiers
CASNo=82159-09-9
PubChem=1549120
SMILES=CC(=CC1=CC=CC=C1)C= C2C(=O)N(C(=S)S2)CC(=O)O
Section2= Chembox Properties
Formula=C₁₅H₁₃NO₃S₂
MolarMass=319.401 g/mol
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Epalrestat is an aldose reductase inhibitor.

"Long-term treatment with epalrestat is well tolerated and can effectively delay the progression of diabetic neuropathy and ameliorate the associated symptoms of the disease, particularly in subjects with good glycemic control and limited microangiopathy." [http://www.medscape.com/viewarticle/540494 July 2006 Epalrestat May Delay Progression and Reduce Symptoms of Diabetic Neuropathy]

References

External links

* [http://www.ncbi.nlm.nih.gov/pubmed/18447661 Epalrestat: an aldose reductase inhibitor for the treatment of diabetic neuropathy.] (2008 review of 6 clinical trials)
* [http://www.chemblink.com/products/82159-09-9.htm Epalrestat at chemblink.com]