NFKB1

NFKB1
Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1

PDB rendering based on 1bfs.
Identifiers
Symbols NFKB1; DKFZp686C01211; EBP-1; KBF1; MGC54151; NF-kappa-B; NF-kappaB; NFKB-p105; NFKB-p50; p105; p50
External IDs OMIM164011 MGI97312 HomoloGene2971 GeneCards: NFKB1 Gene
RNA expression pattern
PBB GE NFKB1 209239 at.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4790 18033
Ensembl ENSG00000109320 ENSMUSG00000028163
UniProt P19838 P25799
RefSeq (mRNA) NM_001165412.1 NM_008689.2
RefSeq (protein) NP_001158884.1 NP_032715.2
Location (UCSC) Chr 4:
103.42 – 103.54 Mb
Chr 3:
135.25 – 135.35 Mb
PubMed search [1] [2]

Nuclear factor NF-kappa-B p105 subunit is a protein that in humans is encoded by the NFKB1 gene.[1]

This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappaB (NF-κB) protein complex. NF-κB is a transcription factor that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NF-κB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions; over 200 known genes are targets of NF-κB in various cell types, under specific conditions. Inappropriate activation of NF-κB has been associated with a number of inflammatory diseases while persistent inhibition of NF-κB leads to inappropriate immune cell development or delayed cell growth.[2]

Contents

Interactions

NFKB1 has been shown to interact with NFKBIE,[3] IKK2,[4][5] MAP3K7IP2,[6] STAT6,[7] ITGB3BP,[8] IκBα,[9][10] NFKB2,[11] RELA,[11][12] RELB,[11] TSC22D3,[13] NOTCH1,[14][15] HDAC1,[16] LYL1,[17] BCL3,[5][18][19] STAT3,[20] MAP3K8,[11][21] MEN1,[22] Nuclear receptor coactivator 1[23][24] and HMGA2.[25]

References

  1. ^ Meyer R, Hatada EN, Hohmann HP, Haiker M, Bartsch C, Rothlisberger U, Lahm HW, Schlaeger EJ, van Loon AP, Scheidereit C (Mar 1991). "Cloning of the DNA-binding subunit of human nuclear factor kappa B: the level of its mRNA is strongly regulated by phorbol ester or tumor necrosis factor alpha". Proc Natl Acad Sci U S A 88 (3): 966–70. doi:10.1073/pnas.88.3.966. PMC 50935. PMID 1992489. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=50935. 
  2. ^ "Entrez Gene: NF-κB nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4790. 
  3. ^ Li, Z; Nabel G J (Oct. 1997). "A new member of the I kappaB protein family, I kappaB epsilon, inhibits RelA (p65)-mediated NF-kappaB transcription". Mol. Cell. Biol. (UNITED STATES) 17 (10): 6184–90. ISSN 0270-7306. PMC 232469. PMID 9315679. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=232469. 
  4. ^ Heissmeyer, V; Krappmann D, Hatada E N, Scheidereit C (Feb. 2001). "Shared pathways of IkappaB kinase-induced SCF(betaTrCP)-mediated ubiquitination and degradation for the NF-kappaB precursor p105 and IkappaBalpha". Mol. Cell. Biol. (United States) 21 (4): 1024–35. doi:10.1128/MCB.21.4.1024-1035.2001. ISSN 0270-7306. PMC 99557. PMID 11158290. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=99557. 
  5. ^ a b Heissmeyer, V; Krappmann D, Wulczyn F G, Scheidereit C (Sep. 1999). "NF-kappaB p105 is a target of IkappaB kinases and controls signal induction of Bcl-3-p50 complexes". EMBO J. (ENGLAND) 18 (17): 4766–78. doi:10.1093/emboj/18.17.4766. ISSN 0261-4189. PMC 1171549. PMID 10469655. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1171549. 
  6. ^ Baek, Sung Hee; Ohgi Kenneth A, Rose David W, Koo Edward H, Glass Christopher K, Rosenfeld Michael G (Jul. 2002). "Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein". Cell (United States) 110 (1): 55–67. doi:10.1016/S0092-8674(02)00809-7. ISSN 0092-8674. PMID 12150997. 
  7. ^ Shen, C H; Stavnezer J (Jun. 1998). "Interaction of stat6 and NF-kappaB: direct association and synergistic activation of interleukin-4-induced transcription". Mol. Cell. Biol. (UNITED STATES) 18 (6): 3395–404. ISSN 0270-7306. PMC 108921. PMID 9584180. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=108921. 
  8. ^ Besta, Felicitas; Massberg Steffen, Brand Korbinian, Müller Elke, Page Sharon, Grüner Sabine, Lorenz Michael, Sadoul Karin, Kolanus Waldemar, Lengyel Ernst, Gawaz Meinrad (Oct. 2002). "Role of beta(3)-endonexin in the regulation of NF-kappaB-dependent expression of urokinase-type plasminogen activator receptor". J. Cell. Sci. (England) 115 (Pt 20): 3879–88. doi:10.1242/jcs.00081. ISSN 0021-9533. PMID 12244126. 
  9. ^ Hay, D C; Kemp G D, Dargemont C, Hay R T (May. 2001). "Interaction between hnRNPA1 and IkappaBalpha is required for maximal activation of NF-kappaB-dependent transcription". Mol. Cell. Biol. (United States) 21 (10): 3482–90. doi:10.1128/MCB.21.10.3482-3490.2001. ISSN 0270-7306. PMC 100270. PMID 11313474. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=100270. 
  10. ^ Malek, S; Huxford T, Ghosh G (Sep. 1998). "Ikappa Balpha functions through direct contacts with the nuclear localization signals and the DNA binding sequences of NF-kappaB". J. Biol. Chem. (UNITED STATES) 273 (39): 25427–35. doi:10.1074/jbc.273.39.25427. ISSN 0021-9258. PMID 9738011. 
  11. ^ a b c d Bouwmeester, Tewis; Bauch Angela, Ruffner Heinz, Angrand Pierre-Olivier, Bergamini Giovanna, Croughton Karen, Cruciat Cristina, Eberhard Dirk, Gagneur Julien, Ghidelli Sonja, Hopf Carsten, Huhse Bettina, Mangano Raffaella, Michon Anne-Marie, Schirle Markus, Schlegl Judith, Schwab Markus, Stein Martin A, Bauer Andreas, Casari Georg, Drewes Gerard, Gavin Anne-Claude, Jackson David B, Joberty Gerard, Neubauer Gitte, Rick Jens, Kuster Bernhard, Superti-Furga Giulio (Feb. 2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. (England) 6 (2): 97–105. doi:10.1038/ncb1086. ISSN 1465-7392. PMID 14743216. 
  12. ^ Palvimo, J J; Reinikainen P, Ikonen T, Kallio P J, Moilanen A, Jänne O A (Sep. 1996). "Mutual transcriptional interference between RelA and androgen receptor". J. Biol. Chem. (UNITED STATES) 271 (39): 24151–6. doi:10.1074/jbc.271.39.24151. ISSN 0021-9258. PMID 8798655. 
  13. ^ Ayroldi, E; Migliorati G, Bruscoli S, Marchetti C, Zollo O, Cannarile L, D'Adamio F, Riccardi C (Aug. 2001). "Modulation of T-cell activation by the glucocorticoid-induced leucine zipper factor via inhibition of nuclear factor kappaB". Blood (United States) 98 (3): 743–53. doi:10.1182/blood.V98.3.743. ISSN 0006-4971. PMID 11468175. 
  14. ^ Guan, E; Wang J, Laborda J, Norcross M, Baeuerle P A, Hoffman T (May. 1996). "T cell leukemia-associated human Notch/translocation-associated Notch homologue has I kappa B-like activity and physically interacts with nuclear factor-kappa B proteins in T cells". J. Exp. Med. (UNITED STATES) 183 (5): 2025–32. doi:10.1084/jem.183.5.2025. ISSN 0022-1007. PMC 2192574. PMID 8642313. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2192574. 
  15. ^ Wang, J; Shelly L, Miele L, Boykins R, Norcross M A, Guan E (Jul. 2001). "Human Notch-1 inhibits NF-kappa B activity in the nucleus through a direct interaction involving a novel domain". J. Immunol. (United States) 167 (1): 289–95. ISSN 0022-1767. PMID 11418662. 
  16. ^ Zhong, Haihong; May Michael J, Jimi Eijiro, Ghosh Sankar (Mar. 2002). "The phosphorylation status of nuclear NF-kappa B determines its association with CBP/p300 or HDAC-1". Mol. Cell (United States) 9 (3): 625–36. doi:10.1016/S1097-2765(02)00477-X. ISSN 1097-2765. PMID 11931769. 
  17. ^ Ferrier, R; Nougarede R, Doucet S, Kahn-Perles B, Imbert J, Mathieu-Mahul D (Jan. 1999). "Physical interaction of the bHLH LYL1 protein and NF-kappaB1 p105". Oncogene (ENGLAND) 18 (4): 995–1005. doi:10.1038/sj.onc.1202374. ISSN 0950-9232. PMID 10023675. 
  18. ^ Thornburg, Natalie J; Pathmanathan Rajadurai, Raab-Traub Nancy (Dec. 2003). "Activation of nuclear factor-kappaB p50 homodimer/Bcl-3 complexes in nasopharyngeal carcinoma". Cancer Res. (United States) 63 (23): 8293–301. ISSN 0008-5472. PMID 14678988. 
  19. ^ Naumann, M; Wulczyn F G, Scheidereit C (Jan. 1993). "The NF-kappa B precursor p105 and the proto-oncogene product Bcl-3 are I kappa B molecules and control nuclear translocation of NF-kappa B". EMBO J. (ENGLAND) 12 (1): 213–22. ISSN 0261-4189. PMC 413194. PMID 8428580. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=413194. 
  20. ^ Yu, Zhiyuan; Zhang Wenzheng, Kone Bruce C (Oct. 2002). "Signal transducers and activators of transcription 3 (STAT3) inhibits transcription of the inducible nitric oxide synthase gene by interacting with nuclear factor kappaB". Biochem. J. (England) 367 (Pt 1): 97–105. doi:10.1042/BJ20020588. ISSN 0264-6021. PMC 1222853. PMID 12057007. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1222853. 
  21. ^ Belich, M P; Salmerón A, Johnston L H, Ley S C (Jan. 1999). "TPL-2 kinase regulates the proteolysis of the NF-kappaB-inhibitory protein NF-kappaB1 p105". Nature (ENGLAND) 397 (6717): 363–8. doi:10.1038/16946. ISSN 0028-0836. PMID 9950430. 
  22. ^ Heppner, C; Bilimoria K Y, Agarwal S K, Kester M, Whitty L J, Guru S C, Chandrasekharappa S C, Collins F S, Spiegel A M, Marx S J, Burns A L (Aug. 2001). "The tumor suppressor protein menin interacts with NF-kappaB proteins and inhibits NF-kappaB-mediated transactivation". Oncogene (England) 20 (36): 4917–25. doi:10.1038/sj.onc.1204529. ISSN 0950-9232. PMID 11526476. 
  23. ^ Lee, S K; Na S Y, Jung S Y, Choi J E, Jhun B H, Cheong J, Meltzer P S, Lee Y C, Lee J W (Jun. 2000). "Activating protein-1, nuclear factor-kappaB, and serum response factor as novel target molecules of the cancer-amplified transcription coactivator ASC-2". Mol. Endocrinol. (UNITED STATES) 14 (6): 915–25. doi:10.1210/me.14.6.915. ISSN 0888-8809. PMID 10847592. 
  24. ^ Na, S Y; Lee S K, Han S J, Choi H S, Im S Y, Lee J W (May. 1998). "Steroid receptor coactivator-1 interacts with the p50 subunit and coactivates nuclear factor kappaB-mediated transactivations". J. Biol. Chem. (UNITED STATES) 273 (18): 10831–4. doi:10.1074/jbc.273.18.10831. ISSN 0021-9258. PMID 9556555. 
  25. ^ Noro, Barbara; Licheri Barbara, Sgarra Riccardo, Rustighi Alessandra, Tessari Michela A, Chau Kai-Yin, Ono Santa Jeremy, Giancotti Vincenzo, Manfioletti Guidalberto (Apr. 2003). "Molecular dissection of the architectural transcription factor HMGA2". Biochemistry (United States) 42 (15): 4569–77. doi:10.1021/bi026605k. ISSN 0006-2960. PMID 12693954. 

Further reading

External links


Wikimedia Foundation. 2010.

Игры ⚽ Нужна курсовая?

Look at other dictionaries:

  • NFKB1 — Обозначения Символы NFKB1 Entrez Gene …   Википедия

  • NFKB1 — Subunidad p105 del factor nuclear NF kappa B Estructura tridimensional de la proteína NFKB1. HUGO …   Wikipedia Español

  • NF-κB — Mechanism of NF κB action. In this figure, the NF κB heterodimer between Rel and p50 proteins is used as an example. While in an inactivated state, NF κB is located in the cytosol complexed with the inhibitory protein IκBα. Through the… …   Wikipedia

  • RELA — For other uses, see RELA Corps. V rel reticuloendotheliosis viral oncogene homolog A (avian) PDB rendering based on 1bft …   Wikipedia

  • RELA — Factor de transcripción p65 Estructura tridimensional de la proteína RELA. HUGO 9955 …   Wikipedia Español

  • NFKB2 — Nuclear factor of kappa light polypeptide gene enhancer in B cells 2 (p49/p100) PDB rendering based on 1a3q …   Wikipedia

  • NFKBIE — Nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, epsilon Identifiers Symbols NFKBIE; IKBE External IDs …   Wikipedia

  • NFKB2 — Обозначения Символы NFKB2; LYT 10 Entrez Gene …   Википедия

  • Receptor (biochemistry) — For other uses, see Receptor (disambiguation). In biochemistry, a receptor is a molecule found on the surface of a cell, which receives specific chemical signals from neighbouring cells or the wider environment within an organism. These signals… …   Wikipedia

  • CREB — redirects here. For other uses, see Clean Renewable Energy Bonds. CREB (top) is a transcription factor capable of binding DNA (bottom) and regulating gene expression. CREB (cAMP response element binding) is a cellular transcription factor. It… …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”