- Digoxin Immune Fab
Digoxin Immune Fab Systematic (IUPAC) name Anti-digoxin antibody fragment Clinical data AHFS/Drugs.com Pregnancy cat. C(US) Legal status ? Routes IV infusion, injection Pharmacokinetic data Half-life 15 hours for DigiFab, 23 hours for Digibind Excretion Renal Identifiers ATC code V03 DrugBank ChEMBL Chemical data Formula C6394H9908N1698O2011S58 Mol. mass 144602.257 g/mol (what is this?)
Digoxin Immune Fab (Ovine) is the generic name for an antidote for overdose of digitalis. It is made from immunoglobulin fragments from sheep who have already been immunized with a digoxin derivative, digoxindicarboxymethoxylamine (DDMA). Its brand names include Digibind and DigiFab, with the former manufactured by GlaxoSmithKline and the latter manufactured by BTG plc.
It works by binding to the digoxin, rendering them unable to bind to their action sites on target cells. The complexes accumulate in the blood and are expelled by the kidney.
Although no contraindications have been noted, the patient must be closely monitored for anaphylactic shock, and anyone allergic to sheep protein, papain, bromelain, or papaya extracts (papain is used to cleave the antibody into Fab and Fc fragments) should not use Digoxin Immune Fab (Ovine). Because it is relatively new, no drug interaction studies have been performed yet.
Antidotes (V03AB) Nervous systemBarbiturate overdoseBemegride • EthamivanBenzodiazepine overdoseGHB overdoseReversal of neuromuscular blockade CardiovascularDigoxin Immune Fab OtherParacetamol toxicity (Acetaminophen)Other Emetic This pharmacology-related article is a stub. You can help Wikipedia by expanding it.