Transcription Factor II F


Transcription Factor II F

protein
Name = general transcription factor IIF, polypeptide 1, 74kDa
caption =


width =
HGNCid = 4652
Symbol = GTF2F1
AltSymbols = TFIIF, BTF4, RAP74
EntrezGene = 2962
OMIM = 189968
RefSeq = NM_002096
UniProt = P35269
PDB =
ECnumber =
Chromosome = 19
Arm = p
Band = 13.3
LocusSupplementaryData =
protein
Name = general transcription factor IIF, polypeptide 2, 30kDa
caption =


width =
HGNCid = 4653
Symbol = GTF2F2
AltSymbols = TFIIF, BTF4, RAP30
EntrezGene = 2963
OMIM = 189969
RefSeq = NM_004128
UniProt = P13984
PDB =
ECnumber =
Chromosome = 13
Arm = q
Band = 14
LocusSupplementaryData =
protein
Name = general transcription factor IIF, polypeptide 2-like
caption =


width =
HGNCid = 4654
Symbol = GTF2F2L
AltSymbols = TFIIF
EntrezGene = 2964
OMIM =
RefSeq = NG_003013
UniProt =
PDB =
ECnumber =
Chromosome = 4
Arm = q
Band = 31.22
LocusSupplementaryData =

Transcription Factor II F (TFIIF) is one of several general transcription factors that make up the RNA polymerase II preinitiation complex.cite book | author = Lewin, Benjamin | title = Genes VIII | publisher = Pearson Prentice Hall | location = Upper Saddle River, NJ | year = 2004 | pages = p636-637 | isbn = 0-13-144946-X | oclc = | doi = ]

Transcription Factor II F is encoded by the gene|GTF2F1, gene|GTF2F2, and gene|GTF2F2L genes.cite journal | author = Finkelstein A, Kostrub CF, Li J, Chavez DP, Wang BQ, Fang SM, Greenblatt J, Burton ZF | title = A cDNA encoding RAP74, a general initiation factor for transcription by RNA polymerase II | journal = Nature | volume = 355 | issue = 6359 | pages = 464–7 | year = 1992 | pmid = 1734284 | doi = 10.1038/355464a0 | issn = ] cite journal | author = Heng HH, Xiao H, Shi XM, Greenblatt J, Tsui LC | title = Genes encoding general initiation factors for RNA polymerase II transcription are dispersed in the human genome | journal = Hum. Mol. Genet. | volume = 3 | issue = 1 | pages = 61–4 | year = 1994 | pmid = 8162052 | doi = | issn = ] cite journal | author = Purrello M, Di Pietro C, Rapisarda A, Mirabile E, Motta S, Sichel G, Grzeschik KH | title = Genetic characterization of general transcription factors TFIIF and TFIIB of Homo sapiens sapiens | journal = Cytogenet. Cell Genet. | volume = 69 | issue = 1-2 | pages = 75–80 | year = 1995 | pmid = 7835093 | doi = | issn = ] DNA is thought to be wrapped one complete turn around the preinitiation complex and it is TFIIF that helps keep this tight wrapping.cite journal | author = Lee TI, Young RA | title = Transcription of eukaryotic protein-coding genes | journal = Annu. Rev. Genet. | volume = 34 | issue = | pages = 77–137 | year = 2000 | pmid = 11092823 | doi = 10.1146/annurev.genet.34.1.77] In the process, the torsional strain on the DNA may aid in DNA melting at the promoter, forming the transcription bubble. Of all the general transcription factors, TFIIF is the most similar to bacterial sigma factor.

See also

* TFIIA
* TFIIB
* TFIID
* TFIIE

References

External links

*


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