- Alan Cranston (1914–2000), American politician from California
- Bryan Cranston (1956–), American actor
- Catherine Cranston (1849–1934), also known as Kate Cranston or Miss Cranston, tea room proprietor
- Earl Cranston (1840 – 1932), Bishop of the Methodist Episcopal Church
- Edwin Cranston, professor of Japanese at Harvard University
- John Cranston, colonial governor of Rhode Island
- Ken Cranston (1917–), former English cricketer
- Maurice Cranston (1920–1993), British philosopher and political scientist
- Murdock Cranston (1938–1996), Former Canadian racquetball champion
- Ross Cranston (1948–), British lawyer and politician, member of Parliament for Dudley
- Samuel Cranston, colonial governor of Rhode Island
- Tim Cranston (1962–), Canadian former professional ice hockey player
- Todd Cranston (1960–) , Canadian former professional racquetball player
- Toller Cranston (1949–), Canadian figure skater and artist
- Alex Cranston, team leader for spies on InSecurity
- Billy Cranston, a geek from the Power Rangers universe
- "Lamont Cranston", an alter ego of The Shadow
- Cranston, Midlothian
- Cranston, Calgary, neighbourhood in Calgary, Alberta
- United States
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