Telomerase reverse transcriptase


Telomerase reverse transcriptase

Telomerase reverse transcriptase (abbreviated to TERT, or hTERT in humans) is a catalytic subunit of the enzyme telomerase.cite journal | author = Kirkpatrick KL, Mokbel K | title = The significance of human telomerase reverse transcriptase (hTERT) in cancer | journal = Eur J Surg Oncol | volume = 27 | issue = 8 | pages = 754–60 | year = 2001 | pmid = 11735173 | doi = 10.1053/ejso.2001.1151 | issn = ] Its absence (usually as a result of a chromosomal mutation) is associated with the disorder Cri du chat.cite journal | author = Zhang A, Zheng C, Hou M, Lindvall C, Li KJ, Erlandsson F, Björkholm M, Gruber A, Blennow E, Xu D | title = Deletion of the telomerase reverse transcriptase gene and haploinsufficiency of telomere maintenance in Cri du chat syndrome | journal = Am. J. Hum. Genet. | volume = 72 | issue = 4 | pages = 940–8 | year = 2003 | pmid = 12629597 | doi = | url = http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=12629597 | issn = ] cite journal | author = Cerruti Mainardi P | title = Cri du Chat syndrome | journal = Orphanet J Rare Dis | volume = 1 | issue = | pages = 33 | year = 2006 | pmid = 16953888 | doi = 10.1186/1750-1172-1-33 | issn = ]

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summary_text = Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mice suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity. [cite web | title = Entrez Gene: TERT telomerase reverse transcriptase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7015| accessdate = ]

References

Further reading

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citations =
*cite journal | author=Mattson MP, Fu W, Zhang P |title=Emerging roles for telomerase in regulating cell differentiation and survival: a neuroscientist's perspective. |journal=Mech. Ageing Dev. |volume=122 |issue= 7 |pages= 659–71 |year= 2001 |pmid= 11322991 |doi=
*cite journal | author=Castillo Ureta H, Barrera Saldaña HA, Martínez Rodríguez HG |title= [Telomerase: an enzyme with multiple applications in cancer research] |journal=Rev. Invest. Clin. |volume=54 |issue= 4 |pages= 342–8 |year= 2003 |pmid= 12415959 |doi=
*cite journal | author=Janknecht R |title=On the road to immortality: hTERT upregulation in cancer cells. |journal=FEBS Lett. |volume=564 |issue= 1-2 |pages= 9–13 |year= 2004 |pmid= 15094035 |doi= 10.1016/S0014-5793(04)00356-4
*cite journal | author=Cristofari G, Sikora K, Lingner J |title=Telomerase unplugged. |journal=ACS Chem. Biol. |volume=2 |issue= 3 |pages= 155–8 |year= 2007 |pmid= 17373762 |doi= 10.1021/cb700037c
*cite journal | author=Beliveau A, Yaswen P |title=Soothing the watchman: telomerase reduces the p53-dependent cellular stress response. |journal=Cell Cycle |volume=6 |issue= 11 |pages= 1284–7 |year= 2007 |pmid= 17534147 |doi=
*cite journal | author=Bellon M, Nicot C |title=Telomerase: a crucial player in HTLV-I-induced human T-cell leukemia. |journal=Cancer genomics & proteomics |volume=4 |issue= 1 |pages= 21–5 |year= 2007 |pmid= 17726237 |doi=

ee also

* telomerase
* reverse transcriptase

External links

*

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