Nuclear receptor subfamily 2, group E, member 1
Symbols NR2E1; TLL; TLX; XTLL
External IDs OMIM603849 MGI1100526 HomoloGene37750 IUPHAR: NR2E1 GeneCards: NR2E1 Gene
RNA expression pattern
PBB GE NR2E1 207443 at tn.png
More reference expression data
Species Human Mouse
Entrez 7101 21907
Ensembl ENSG00000112333 ENSMUSG00000019803
UniProt Q9Y466 Q3UXE8
RefSeq (mRNA) NM_003269.3 NM_152229.2
RefSeq (protein) NP_003260.1 NP_689415.1
Location (UCSC) Chr 6:
108.49 – 108.51 Mb
Chr 10:
42.28 – 42.3 Mb
PubMed search [1] [2]

Nuclear receptor TLX (homologue of the Drosophila tailless gene) also known as NR2E1 (Nuclear receptor subfamily 2 group E member 1) is a protein that in humans is encoded by the NR2E1 gene.[1] TLX is a member of the nuclear receptor family of intracellular transcription factors.



TLX regulates the expression of another nuclear receptor, RAR.[2]

TLX also is essential for normal brain-eye coordination and appears to play a role in control of aggressive behavior.[3]

Adult neural stem cells are nuclear receptor TLX-positive and TLX expression in these cells is crucial in maintaining their undifferentiated state.[4] Furthermore TLX regulates adult neural stem cell proliferation. Removal of TLX from the adult mouse brain resulted in a reduction of stem cell proliferation and spatial learning.[5]

Tlx-positive cells of the subventricular zone of adult mouse brain are self-renewing stem cells. Mutation of the Tlx gene in adult mouse brain leads to complete loss of neurogenesis in the subventricular zone. Tlx is also required for transition from radial glial cells to astrocyte-like neural stem cells.[6]


  1. ^ Jackson A, Panayiotidis P, Foroni L (1998). "The human homologue of the Drosophila tailless gene (TLX): characterization and mapping to a region of common deletion in human lymphoid leukemia on chromosome 6q21". Genomics 50 (1): 34–43. doi:10.1006/geno.1998.5270. PMID 9628820. 
  2. ^ Kobayashi M, Yu RT, Yasuda K, Umesono K (2000). "Cell-Type-Specific Regulation of the Retinoic Acid Receptor Mediated by the Orphan Nuclear Receptor TLX". Mol. Cell. Biol. 20 (23): 8731–9. doi:10.1128/MCB.20.23.8731-8739.2000. PMC 86495. PMID 11073974. 
  3. ^ Abrahams BS, Kwok MC, Trinh E, Budaghzadeh S, Hossain SM, Simpson EM (2005). "Pathological aggression in "fierce" mice corrected by human nuclear receptor 2E1". J. Neurosci. 25 (27): 6263–70. doi:10.1523/JNEUROSCI.4757-04.2005. PMID 16000615. 
  4. ^ Shi Y, Chichung Lie D, Taupin P, Nakashima K, Ray J, Yu RT, Gage FH, Evans RM (January 2004). "Expression and function of orphan nuclear receptor TLX in adult neural stem cells". Nature 427 (6969): 78–83. doi:10.1038/nature02211. PMID 14702088. 
  5. ^ Zhang CL, Zou Y, He W, Gage FH, Evans RM (February 2008). "A role for adult TLX-positive neural stem cells in learning and behaviour". Nature 451 (7181): 1004–7. doi:10.1038/nature06562. PMID 18235445. 
  6. ^ Liu HK, Belz T, Bock D, Takacs A, Wu H, Lichter P, Chai M, Schütz G (September 2008). "The nuclear receptor tailless is required for neurogenesis in the adult subventricular zone". Genes Dev. 22 (18): 2473–8. doi:10.1101/gad.479308. PMC 2546695. PMID 18794344. 

Further reading

External links

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