Figure 1: Dendrimer and dendron

Dendrimers are repetitively branched molecules. [1] [2] The name comes from the Greek word "δένδρον" (pronounced dendron), which translates to "tree". Synonymous terms for dendrimer include arborols and cascade molecules. However, dendrimer is currently the internationally accepted term. A dendrimer is typically symmetric around the core, and often adopts a spherical three-dimensional morphology. The word dendron is also encountered frequently. A dendron usually contains a single chemically addressable group called the focal point. The difference between dendrons and dendrimers is illustrated in figure one, but the terms are typically encountered interchangeably.[3]

Figure 2: Crystal structure of a first-generation polyphenylene dendrimer reported by Müllen et al.[4]

The first dendrimers were made by divergent synthesis approaches by Fritz Vögtle in 1978,[5] R.G. Denkewalter at Allied Corporation in 1981,[6][7] Donald Tomalia at Dow Chemical in 1983[8] and in 1985,[9][10] and by George Newkome in 1985.[11] In 1990 a convergent synthetic approach was introduced by Jean Fréchet.[12] Dendrimer popularity then greatly increased, resulting in more than 5,000 scientific papers and patents by the year 2005.



Dendritic molecules are characterized by structural perfection. Dendrimers and dendrons are monodisperse and usually highly symmetric, spherical compounds. The field of dendritic molecules can be roughly divided into low-molecular weight and high-molecular weight species. The first category includes dendrimers and dendrons, and the latter includes dendronized polymers, hyperbranched polymers, and the polymer brush.

The properties of dendrimers are dominated by the functional groups on the molecular surface, however, there are examples of dendrimers with internal functionality.[13][14][15] Dendritic encapsulation of functional molecules allows for the isolation of the active site, a structure that mimics that of active sites in biomaterials.[16][17][18] Also, it is possible to make dendrimers water soluble, unlike most polymers, by functionalizing their outer shell with charged species or other hydrophilic groups. Other controllable properties of dendrimers include toxicity, crystallinity, tecto-dendrimer formation, and chirality.[3]

Dendrimers are also classified by generation, which refers to the number of repeated branching cycles that are performed during its synthesis. For example if a dendrimer is made by convergent synthesis (see below), and the branching reactions are performed onto the core molecule three times, the resulting dendrimer is considered a third generation dendrimer. Each successive generation results in a dendrimer roughly twice the molecular weight of the previous generation. Higher generation dendrimers also have more exposed functional groups on the surface, which can later be used to customize the dendrimer for a given application.[19]


Figure 3: Synthesis to second generation arborol

One of the very first dendrimers, the Newkome dendrimer, was synthesized in 1985. This macromolecule is also commonly known by the name arborol. Figure 3 outlines the mechanism of the first two generations of aborol through a divergent route (discussed below). The synthesis is started by nucleophilic substitution of 1-bromopentane by triethyl sodiomethanetricarboxylate in dimethylformamide and benzene. The ester groups were then reduced by lithium aluminium hydride to a triol in a deprotection step. Activation of the chain ends was achieved by converting the alcohol groups to tosylate groups with tosyl chloride and pyridine. The tosyl group then served as leaving groups in another reaction with the tricarboxylate, forming generation two. Further repetition of the two steps leads to higher generations of arborol.[11]

Poly(amidoamine), or PAMAM, is perhaps the most well known dendrimer. The core of PAMAM is a diamine (commonly ethylenediamine), which is reacted with methyl acrylate, and then another ethylenediamine to make the generation-0 (G-0) PAMAM. Successive reactions create higher generations, which tend to have different properties. Lower generations can be thought of as flexible molecules with no appreciable inner regions, while medium sized (G-3 or G-4) do have internal space that is essentially separated from the outer shell of the dendrimer. Very large (G-7 and greater) dendrimers can be thought of more like solid particles with very dense surfaces due to the structure of their outer shell. The functional group on the surface of PAMAM dendrimers is ideal for click chemistry, which gives rise to many potential applications.[20]

Dendrimers can be considered to have three major portions: a core, an inner shell, and an outer shell. Ideally, a dendrimer can be synthesized to have different functionality in each of these portions to control properties such as solubility, thermal stability, and attachment of compounds for particular applications. Synthetic processes can also precisely control the size and number of branches on the dendrimer. There are two defined methods of dendrimer synthesis, divergent synthesis and convergent synthesis. However, because the actual reactions consist of many steps needed to protect the active site, it is difficult to synthesize dendrimers using either method. This makes dendrimers hard to make and very expensive to purchase. At this time, there are only a few companies that sell dendrimers; Polymer Factory Sweden AB[21] commercializes biocompatible bis-MPA dendrimers and Dendritech[22] is the only kilogram-scale producers of PAMAM dendrimers. Dendritic Nanotechnologies Inc.,[23] from Mount Pleasant, Michigan, USA produces PAMAM dendrimers and other proprietary dendrimers.

Divergent Methods

Figure 4: Schematic of divergent synthesis of dendrimers

The dendrimer is assembled from a multifunctional core, which is extended outward by a series of reactions, commonly a Michael reaction. Each step of the reaction must be driven to full completion to prevent mistakes in the dendrimer, which can cause trailing generations (some branches are shorter than the others). Such impurities can impact the functionality and symmetry of the dendrimer, but are extremely difficult to purify out because the relative size difference between perfect and imperfect dendrimers is very small.[19]

Convergent Methods

Figure 5: Schematic of convergent synthesis of dendrimers

Dendrimers are built from small molecules that end up at the surface of the sphere, and reactions proceed inward building inward and are eventually attached to a core. This method makes it much easier to remove impurities and shorter branches along the way, so that the final dendrimer is more monodisperse. However dendrimers made this way are not as large as those made by divergent methods because crowding due to steric effects along the core is limiting.[19]

Click chemistry

Figure 6: Dendrimer DA reaction Mullen 1996

Dendrimers have been prepared via click chemistry, employing Diels-Alder reactions,[24] thiol-ene reactions [25] and azide-alkyne reactions.[26][27][28] An example is the synthesis of certain polyphenylene dendrimers can be seen in figure 6.[29]

There are ample avenues that can be opened by exploring this chemistry in dendrimer synthesis.


Applications of dendrimers typically involve conjugating other chemical species to the dendrimer surface that can function as detecting agents (such as a dye molecule), affinity ligands, targeting components, radioligands, imaging agents, or pharmaceutically active compounds. Dendrimers have very strong potential for these applications because their structure can lead to multivalent systems. In other words, one dendrimer molecule has hundreds of possible sites to couple to an active species. Researchers aimed to utilize the hydrophobic environments of the dendritic media to conduct photochemical reactions that generate the products that are synthetically challenged. Carboxylic acid and phenol terminated water soluble dendrimers were synthesized to establish their utility in drug delivery as well as conducting chemical reactions in their interiors.[30] This might allow researchers to attach both targeting molecules and drug molecules to the same dendrimer, which could reduce negative side effects of medications on healthy cells.[20]

Dendrimers can also be used as a solubilizing agent. Since their introduction in the mid-1980s, this novel class of dendrimer architecture has been a prime candidate for hosts guest chemistry.[31] Dendrimers with hydrophobic core and hydrophilic periphery have shown to exhibit micelle-like behavior and have container properties in solution.[32] The use of dendrimers as unimolecular micelles was proposed by Newkome in 1985.[33] This analogy highlighted the utility of dendrimers as solubilizing agents. [34] The majority of drugs available in pharmaceutical industry are hydrophobic in nature and this property in particular creates major formulation problems. This drawback of drugs can be ameliorated by dendrimeric scaffolding, which can be used to encapsulate as well as to solubilize the drugs because of the capability of such scaffolds to participate in extensive hydrogen bonding with water.[35][36][37][38][39][40] Dendrimer labs throughout the planet are persistently trying to manipulate dendrimer’s solubilizing trait, in their way to explore dendrimer as drug delivery [41][42] and target specific carrier.[43][44][45]

Drug Delivery

Figure 7: Schematic of a G-5 PAMAM dendrimer conjugated to both a dye molecule and a strand of DNA.

Approaches for delivering unaltered natural products using polymeric carriers is of widespread interest, dendrimers have been explored for the encapsulation of hydrophobic compounds and for the delivery of anticancer drugs. The physical characteristics of dendrimers, including their monodispersity, water solubility, encapsulation ability, and large number of functionalizable peripheral groups, make these macromolecules appropriate candidates for evaluation as drug delivery vehicles. There are three methods for using dendrimers in drug delivery: first, the drug is covalently attached to the periphery of the dendrimer to form dendrimer prodrugs, second the drug is coordinated to the outer functional groups via ionic interactions, or third the dendrimer acts as a unimolecular micelle by encapsulating a pharmaceutical through the formation of a dendrimer-drug supramolecular assembly.[46][47] The use of dendrimers as drug carriers by encapsulating hydrophobic drugs is a potential method for delivering highly active pharmaceutical compounds that may not be in clinical use due to their limited water solubility and resulting suboptimal pharmacokinetics. Dendrimers have been widely explored for controlled delivery of antiretroviral bioactives [48] The inherent antiretroviral activity of dendrimers enhances their efficacy as carriers for antiretroviral drugs [49][50] The dendrimer enhances both the uptake and retention of compounds within cancer cells, a finding that was not anticipated at the onset of studies. The encapsulation increases with dendrimer generation and this method may be useful to entrap drugs with a relatively high therapeutic dose. Studies based on this dendritic polymer also open up new avenues of research into the further development of drug-dendrimer complexes specific for a cancer and/or targeted organ system. These encouraging results provide further impetus to design, synthesize, and evaluate dendritic polymers for use in basic drug delivery studies and eventually in the clinic.[46][51]

Gene Delivery

The ability to deliver pieces of DNA to the required parts of a cell includes many challenges. Current research is being performed to find ways to use dendrimers to traffic genes into cells without damaging or deactivating the DNA. To maintain the activity of DNA during dehydration, the dendrimer/DNA complexes were encapsulated in a water soluble polymer, and then deposited on or sandwiched in functional polymer films with a fast degradation rate to mediate gene transfection. Based on this method, PAMAM dendrimer/DNA complexes were used to encapsulate functional biodegradable polymer films for substratemediated gene delivery. Research has shown that the fast degrading functional polymer has great potential for localized transfection.[52][53][54]


Scientists have also studied dendrimers for use in sensor technologies. Studied systems include proton or pH sensors using poly(propylene imine),[55] cadmium-sulfide/polypropylenimine tetrahexacontaamine dendrimer composites to detect fluorescence signal quenching,[56] and poly(propylenamine) first and second generation dendrimers for metal cation photodetection[57] amongst others. Research in this field is vast and ongoing due to the potential for multiple detection and binding sites in dendritic structures.

See also


  1. ^ D. Astruc, E. Boisselier, C. Ornelas (2010). "Dendrimers Designed for Functions: From Physical, Photophysical, and Supramolecular Properties to Applications in Sensing, Catalysis, Molecular Electronics, and Nanomedicine". Chem. Rev. 110 (4): 1857–1959. doi:10.1021/cr900327d. 
  2. ^ Vögtle, Fritz / Richardt, Gabriele / Werner, Nicole Dendrimer Chemistry Concepts, Syntheses, Properties, Applications 2009 ISBN 3-527-32066-0
  3. ^ a b Nanjwade, Basavaraj K.; Hiren M. Bechraa, Ganesh K. Derkara, F.V. Manvia, Veerendra K. Nanjwade (2009). "Dendrimers: Emerging polymers for drug-delivery systems". European Journal of Pharmaceutical Sciences (Elsevier) 38 (3): 185–196. doi:10.1016/j.ejps.2009.07.008. PMID 19646528. 
  4. ^ Roland E. Bauer, Volker Enkelmann, Uwe M. Wiesler, Alexander J. Berresheim, Klaus Müllen (2002). "Single-Crystal Structures of Polyphenylene Dendrimers". Chemistry: A European Journal 8 (17): 3858. doi:10.1002/1521-3765(20020902)8:17<3858::AID-CHEM3858>3.0.CO;2-5. 
  5. ^ Egon Buhleier, Winfried Wehner, Fritz Vögtle (1978). ""Cascade"- and "Nonskid-Chain-like" Syntheses of Molecular Cavity Topologies". Synthesis 1978 (2): 155–158. doi:10.1055/s-1978-24702. 
  6. ^ U.S. Patent 4,289,872 Denkewalter, Robert G., Kolc, Jaroslav, Lukasavage, William J.
  7. ^ U.S. Patent 4,410,688
  8. ^ U.S. Patent 4,507,466
  9. ^ D. A. Tomalia, H. Baker, J. Dewald, M. Hall, G. Kallos, S. Martin, J. Roeck, J. Ryder and P. Smith (1985). "A New Class of Polymers: Starburst-Dendritic Macromolecules". Polymer Journal 17: 117. doi:10.1295/polymj.17.117. 
  10. ^ "Treelike molecules branch out - chemist Donald A. Tomalia synthesized first dendrimer molecule - Chemistry - Brief Article". Science News. 1996. 
  11. ^ a b George R. Newkome, Zhongqi Yao, Gregory R. Baker, Vinod K. Gupta (1985). "Micelles. Part 1. Cascade molecules: a new approach to micelles. A [27]-arborol". J. Org. Chem. 50 (11): 2003. doi:10.1021/jo00211a052. 
  12. ^ Hawker, C. J.; Fréchet, J. M. J. (1990). "Preparation of polymers with controlled molecular architecture. A new convergent approach to dendritic macromolecules". J. Am. Chem. Soc. 112 (21): 7638. doi:10.1021/ja00177a027. 
  13. ^ Bifunctional Dendrimers: From Robust Synthesis and Accelerated One-Pot Postfunctionalization Strategy to Potential Applications P. Antoni, Y. Hed, A. Nordberg, D. Nyström, H. von Holst, A. Hult and M. Malkoch Angew. Int. Ed., 2009, 48 (12), pp 2126-2130 doi:10.1002/anie.200804987 PMID 19117006
  14. ^ J. R. McElhanon and D. V. McGrath JOC, 2000, 65 (11), pp 3525-3529 doi:10.1021/jo000207a
  15. ^ C. O. Liang and J. M. J. Fréchet Macromolecules, 2005, 38 (15), pp 6276-6284 doi:10.1021/ma050818a
  16. ^ S. Hecht, J. M. J. Fréchet (2001). "Dendritic Encapsulation of Function: Applying Nature's Site Isolation Principle from Biomimetics to Materials Science". Angew. Chem. Int. Ed. 40 (1): 74–91. doi:10.1002/1521-3773(20010105)40:1<74::AID-ANIE74>3.0.CO;2-C. PMID 11169692. 
  17. ^ Frechet, Jean M.; Donald A. Tomalia (March 2002). Dendrimers and Other Dendritic Polymers. New York, NY: John Wiley & Sons. ISBN 978-0-471-63850-6. 
  18. ^ M. Fischer, F. Vogtle (1999). "Dendrimers: From Design to Application—A Progress Report". Angew. Chem. Int. Ed. 38 (7): 884. doi:10.1002/(SICI)1521-3773(19990401)38:7<884::AID-ANIE884>3.0.CO;2-K. 
  19. ^ a b c Holister, Paul; Christina Roman Vas, Tim Harper (October 2003). "Dendrimers: Technology White Papers". Cientifica. Retrieved 17 March 2010. 
  20. ^ a b Hermanson, Greg T. (2008). "7". Bioconjugate Techniques (2nd ed.). London: Academic Press of Elsevier. ISBN 978-0-12-370501-3. 
  21. ^ Polymer Factory AB, Stockholm, Sweden.Polymer Factory
  22. ^ Dendritech Inc., from Midland, Michigan, USA.Dendritech.
  23. ^
  24. ^ Diels–Alder “Click” Chemistry in Designing Dendritic Macromolecules, Gregory Franc and Ashok K. Kakkar Chem. Eur. J. 2009 doi:10.1002/chem.200900252
  25. ^ Robust, Efficient, and Orthogonal Synthesis of Dendrimers via Thiol-ene “Click” Chemistry Kato L. Killops, Luis M. Campos and Craig J. Hawker J. Am. Chem. Soc., 2008, 130 (15), pp 5062–5064 doi:10.1021/ja8006325
  26. ^ A chemoselective approach for the accelerated synthesis of well-defined dendritic architectures P. Antoni, D. Nyström, C. J. Hawker, A. Hult and M. Malkoch Chem. Comm., 2007, 22, pp 2249-2251 doi:10.1039/b703547k PMID 17534506
  27. ^ New methodologies in the construction of dendritic materials A. Carlmark, C. J. Hawker, A. Hult and M. Malkoch Chem. Soc. Rev., 2009, 38, pp 352 - 362 doi:10.1039/b711745k PMID 19169453
  28. ^ Dendrimer Design Using Cu(I)-Catalyzed Alkyne-Azide Click Chemistry, G. Franc, A. Kakkar Chem. Comm., 2008, pp 5267 - 5276 doi:10.1039/b809870k
  29. ^ Polyphenylene Dendrimers: From Three-Dimensional to Two-Dimensional Structures Angewandte Chemie International Edition in English Volume 36, Issue 6, Date: April 4, 1997, Pages: 631-634 Frank Morgenroth, Erik Reuther, Klaus Müllen doi:10.1002/anie.199706311
  30. ^ Dendrimers as Photochemical Reaction Media. Photochemical Behavior of Unimolecular and Bimolecular Reactions in Water-Soluble Dendrimers" Lakshmi S. Kaanumalle,† R. Ramesh,‡ Murthy V. S. N. Maddipatla,† Jayaraj Nithyanandhan,‡ Narayanaswamy Jayaraman,*‡ and V. Ramamurthy. Journal of Organic Chemistry, 2005, (70), 5062 - 5069 [1] [2]
  31. ^ D.A. Tomalia, A.M. Naylor, W.A. Goddard III (1990). "Starburst Dendrimers: Molecular-Level Control of Size, Shape, Surface Chemistry, Topology, and Flexibility from Atoms to Macroscopic Matter". Angew. Chem. Int. Ed. Engl. 29 (2): 138–175. doi:10.1002/anie.199001381. 
  32. ^ J. M. J. Frechet (1994). "Functional Polymers and Dendrimers: Reactivity, Molecular Architecture, and Interfacial Energy". Science 263 (5154): 1710–1715. doi:10.1126/science.8134834. 
  33. ^ M. Liu, K Kono, J. Frechet (2000). "Water-soluble unimolecular micelles: their potential as drug delivery agents". J. Cont. Rel. 65: 121–131. 
  34. ^ G.R. Newkome, Z.Q. Yao, G.R. Baker, V.K. Gupta (1985). "Micelles Part 1. Cascade molecules: a new approach to micelles, A-arborol". J. Org. Chem 50: 155–158. 
  35. ^ Stevelmens, S., Hest, J. C. M., Jansen, J. F. G. A., Boxtel, D. A. F. J., de Bravander-van den, B., Miejer, E. W. (1996). "Synthesis, characterisation and guest-host properties of inverted unimolecular micelles". J Am Chem Soc. 118 (31): 7398–7399. doi:10.1021/ja954207h. 
  36. ^ Gupta, U; Agashe, H.B.; Asthana, A.; Jain, N.K. (2006). "Dendrimers: Novel Polymeric Nanoarchitectures for Solubility Enhancement Biomacromolecules". Synthesis 7: 155–158. 
  37. ^ T.P. Thomas, I.J. Majoros, A. Kotlyar, J.F. Kukowska-Latallo, A. Bielinska, A. Myc, J.R. Baker Jr. (2005). "Targeting and Inhibition of Cell Growth by an Engineered Dendritic Nanodevice". J. Med. Chem. 48 (11): 3729–3735. doi:10.1021/jm040187v. 
  38. ^ D. Bhadra, S. Bhadra, P. Jain, N.K.Jain (2002). "Pegnology: a review of PEG-ylated systems". Synthesis 57: 5–29. 
  39. ^ Asthana, A.; Chauhan, A. S.; Diwan, P. V.; Jain, N. K. (2005). "Poly (amidoamine) (PAMAM) dendritic nanostructures for controlled site-specific delivery of anti-inflammatory active ingredient". AAPS PharmSciTech 6 (3): E536–E542. doi:10.1208/pt060367. 
  40. ^ D. Bhadra, S. Bhadra, S. Jain, N.K. Jain (2003). "A PEGylated, dendritic nanoparticulate carrier of fluorouracil". Synthesis 257: 111–124. 
  41. ^ A.J. Khopade, F. Caruso, P. Tripathi, S. Nagaich, N.K. Jain (2002). ""Cascade"- and " Effect of dendrimer on entrapment and release of bioactive from liposomes". Int. J. Pharm. 232: 157–162. doi:10.1016/S0378-5173(01)00901-2. 
  42. ^ Prajapati RN, Tekade RK, Gupta U, Gajbhiye V, Jain NK (2009). "Dendimer-Mediated Solubilization, Formulation Development and in Vitro-in Vivo Assessment of Piroxicam". Synthesis 6: 940–950. 
  43. ^ A.S. Chauhan, S. Sridevi, K.B. Chalasani, A.K. Jain, S.K. Jain, N.K. Jain, P.V. Diwan (2003). "Dendrimer-mediated transdermal delivery: enhanced bioavailability of indomethacin". Synthesis 90: 335–343. 
  44. ^ J.F. Kukowska-Latallo, K.A. Candido, Z. Cao, S.S. Nigavekar, I.J. Majoros, T.P. Thomas, L.P. Balogh, M.K. Khan, J.R. Baker Jr. (2005). "Nanoparticle Targeting of Anticancer Drug Improves Therapeutic Response in Animal Model of Human Epithelial". Synthesis 65: 5317–5324. 
  45. ^ A. Quintana, E. Raczka, L. Piehler, I. Lee, A. Myc, I. Majoros, A.K. Patri, T. Thomas, J. Mule, J.R. Baker Jr. (2002). "Design and Function of a Dendrimer-Based Therapeutic nanodevice targeted to tumor cells through the folate receptor". Synthesis 19: 1310–1316. 
  46. ^ a b Morgan, Meredith T.; Yuka Nakanishi, David J. Kroll, Aaron P. Griset, Michael A. Carnahan, Michel Wathier, Nicholas H. Oberlies, Govindarajan Manikumar, Mansukh C. Wani and Mark W. Grinstaff (2006Meredith T. Morgan1). "Dendrimer-Encapsulated Camptothecins". American Association for Cancer Research (1 Department of Chemistry, Duke University, 2 Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina; 3 Natural Products Laboratory, Research Triangle Institute, Research Triangle Park, North Carolina; and 4 Departments of Biomedical Engineering and Chemistry, Metcalf Center for Science and Engineering, Boston University, Boston, Massachusetts) 66 (24): 11913–21. doi:10.1158/0008-5472.CAN-06-2066. PMID 17178889. 
  47. ^ Tekade, Rakesh Kumar; Tathagata Dutta, Virendra Gajbhiye and Narendra Kumar Jain (2009). "Exploring dendrimer towards dual drug delivery". Journal of Microencapsulation (Pharmaceutics Research Laboratory, Department of Pharmaceutical Sciences, Dr Hari Singh Gour University,) 26 (4): 287–296. doi:10.1080/02652040802312572. PMID 18791906. 
  48. ^ Tathagata Dutta and N.K.Jain Targeting Potential and Anti HIV activity of mannosylated fifth generation poly (propyleneimine) Dendrimers. Biochimica et Biophysica Acta. 2007; 1770: 681-686.
  49. ^ Tathagata Dutta, Minakshi Garg, Narendra K. Jain. Targeting of Efavirenz Loaded Tuftsin Conjugated Poly(propyleneimine) dendrimers to HIV infected macrophages in vitro. Eur. J. Pharm. Sci. 2008.34(2-3):181-189.
  50. ^ Tathagata Dutta, Hrushikesh B. Agashe, Minakshi Garg, Prahlad Balakrishnan, Madhulika Kabra, & Narendra K. Jain. Poly (propyleneimine) dendrimer based nanocontainers for targeting of efavirenz to human monocytes/macrophages in vitro. Journal of Drug Targeting. 2007; 15(1): 84-96.
  51. ^ Cheng, Yiyun; Qinglin Wu, Yiwen Li, and Tongwen Xu (2008). "External Electrostatic Interaction versus Internal Encapsulation between Cationic Dendrimers and Negatively Charged Drugs: Which Contributes More to Solubility Enhancement of the Drugs?". Journal of Physical Chemistry B (Laboratory of Functional Membranes, Department of Chemistry, University of Science and Technology of China) 112 (30): 8884–8890. doi:10.1021/jp801742t. PMID 18605754. 
  52. ^ Fu, Hui-Li; Si-Xue Cheng, Xian-Zheng Zhang, Ren-Xi Zhuo (2008). "Dendrimer/DNA complexes encapsulated functional biodegradable polymer for substrate-mediated gene delivery". The Journal of Gene Medicine (Key Laboratory of Biomedical Polymers of Ministry of Education,Department of Chemistry, Wuhan University, Wuhan, People’s Republic of China) 10 (12): 1334–1342. doi:10.1002/jgm.1258. PMID 18816481. 
  53. ^ Fu, HL; Cheng SX, Zhang XZ (2007). "Dendrimer/DNA complexes encapsulated in a water soluble polymer and supported on fast degrading star poly(DL-lactide) for localized gene delivery". Journal of Control Release (Key Laboratory of Biomedical Polymers of Ministry of Education, Department of Chemistry, Wuhan University) 124 (3): 181–188.. doi:10.1016/j.jconrel.2007.08.031. PMID 17900738. 
  54. ^ Tathagata Dutta, Minakshi Garg, and N.K.Jain. Poly(propyleneimine) dendrimer and dendrosome based genetic immunization against Hepatitis B. Vaccine. 2008. 26(27-28): 3389-3394.
  55. ^ Fernandes, Edson G. R.; Vieira, Nirton C. S.; de Queiroz, Alvaro A. A.; Guimaraes, Francisco E. G.; Zucolotto, Valtencir. (2010). "Immobilization of Poly(propylene imine) Dendrimer/Nickel Phtalocyanine as Nanostructured Multilayer Films To Be Used as Gate Membranes for SEGFET pH Sensors". Journal of Physical Chemistry C (American Chemical Society) 114 (14): 6478–6483. doi:10.1021/jp9106052. 
  56. ^ Campos, Bruno B; Algarra, Manuel; Esteves da Silva, Joaquim C. G (2010). "Fluorescent Properties of a Hybrid Cadmium Sulfide-Dendrimer Nanocomposite and its Quenching with Nitromethane". Journal of Fluorescence (Springer) 20 (1): 143–151. doi:10.1007/s10895-009-0532-5. PMID 19728051. 
  57. ^ Grabchev, Ivo; Staneva, Desislava; Chovelon, Jean-Marc (2010). "Photophysical investigations on the sensor potential of novel, poly(propylenamine) dendrimers modified with 1,8-naphthalimide units". Dyes and Pigments (Elsevier Ltd.,) 85 (3): 189–193. doi:10.1016/j.dyepig.2009.10.023. 

Wikimedia Foundation. 2010.

Look at other dictionaries:

  • dendrimer — dendrimeras statusas T sritis chemija apibrėžtis Polimeras, iš kurio makromolekulių centrinio atomo arba klasterio atsišakoja keletas grandinių. atitikmenys: angl. dendrimer; dendritic polymer rus. дендример ryšiai: sinonimas – dendritinis… …   Chemijos terminų aiškinamasis žodynas

  • Dendrimer — Dendrimere (vom griechischen Dendros – der Baum) sind chemische Verbindungen, deren Struktur ausgehend von einem Verzweigungskern gleich einem Baum verästelt ist, wobei man von Dendrimeren dann spricht, wenn diese Verästelungen aus repetitiven… …   Deutsch Wikipedia

  • dendrimer — den·dri·mer (dĕnʹdrə mər) n. A polymer in which the atoms are arranged in many branches and subbranches along a central backbone of carbon atoms. Also called cascade molecule.   [dendro + alteration of polymer.] * * * …   Universalium

  • dendrimer — noun a) Any polymer or oligomer having branches of atoms strung off of a central spine b) A graph formed of branches from a central core …   Wiktionary

  • Dendrimer — ◆ Den|dri|mer 〈n. 11; Chem.〉 kugelförmiges, hochverzweigtes, polymeres Molekül, das von einem Kernmolekül ausgehend synthetisiert wird ◆ Die Buchstabenfolge den|dr... kann in Fremdwörtern auch dend|r... getrennt werden. * * * Den|d|ri|mer [griech …   Universal-Lexikon

  • dendrimer — n. (Chemistry) synthetic polymer having a branching structure like a tree …   English contemporary dictionary

  • dendrimer — [ dɛndrɪmə] noun Chemistry a synthetic polymer with a branching, tree like structure …   English new terms dictionary

  • dendrimer — A polymer that repeatedly branches until stopped by the physical constraint of having formed a complete, hollow sphere. These structures possess sites on their exterior surface to which DNA fragments can be attached, and are thus useful as… …   Glossary of Biotechnology

  • dendrimer — denˈdrimer / drəm / noun (chem) A polymer that has a tree like branched molecular structure • • • Main Entry: ↑dendro …   Useful english dictionary

  • Dendrosome — Dendrosomes are novel vesicular, spherical, supramolecular entities wherein the dendrimer–nucleic acid complex is encapsulated within a lipophilic shell. They possess negligible hemolytic toxicity and higher transfection efficiency, and they are… …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.