Structural maintenance of chromosomes 1A, also known as SMC1A, is a human gene.cite web | title = Entrez Gene: SMC1A structural maintenance of chromosomes 1A| url =| accessdate = ]

section_title =
summary_text = Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1L2 or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation.cite web | title = Entrez Gene: SMC1A structural maintenance of chromosomes 1A| url =| accessdate = ]

ee also

* SMC protein


Further reading

citations =
*cite journal | author=Nakajima D, Okazaki N, Yamakawa H, "et al." |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99–106 |year= 2003 |pmid= 12168954 |doi=
*cite journal | author=Rocques PJ, Clark J, Ball S, "et al." |title=The human SB1.8 gene (DXS423E) encodes a putative chromosome segregation protein conserved in lower eukaryotes and prokaryotes. |journal=Hum. Mol. Genet. |volume=4 |issue= 2 |pages= 243–9 |year= 1995 |pmid= 7757074 |doi=
*cite journal | author=Brown CJ, Miller AP, Carrel L, "et al." |title=The DXS423E gene in Xp11.21 escapes X chromosome inactivation. |journal=Hum. Mol. Genet. |volume=4 |issue= 2 |pages= 251–5 |year= 1995 |pmid= 7757075 |doi=
*cite journal | author=Matoba R, Okubo K, Hori N, "et al." |title=The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression. |journal=Gene |volume=146 |issue= 2 |pages= 199–207 |year= 1994 |pmid= 8076819 |doi=
*cite journal | author=Nagase T, Seki N, Ishikawa K, "et al." |title=Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1. |journal=DNA Res. |volume=3 |issue= 1 |pages= 17–24 |year= 1996 |pmid= 8724849 |doi=
*cite journal | author=Chen Y, Sharp ZD, Lee WH |title=HEC binds to the seventh regulatory subunit of the 26 S proteasome and modulates the proteolysis of mitotic cyclins. |journal=J. Biol. Chem. |volume=272 |issue= 38 |pages= 24081–7 |year= 1997 |pmid= 9295362 |doi=
*cite journal | author=Schmiesing JA, Ball AR, Gregson HC, "et al." |title=Identification of two distinct human SMC protein complexes involved in mitotic chromosome dynamics. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 22 |pages= 12906–11 |year= 1998 |pmid= 9789013 |doi=
*cite journal | author=Zheng L, Chen Y, Lee WH |title=Hec1p, an evolutionarily conserved coiled-coil protein, modulates chromosome segregation through interaction with SMC proteins. |journal=Mol. Cell. Biol. |volume=19 |issue= 8 |pages= 5417–28 |year= 1999 |pmid= 10409732 |doi=
*cite journal | author=Losada A, Yokochi T, Kobayashi R, Hirano T |title=Identification and characterization of SA/Scc3p subunits in the Xenopus and human cohesin complexes. |journal=J. Cell Biol. |volume=150 |issue= 3 |pages= 405–16 |year= 2000 |pmid= 10931856 |doi=
*cite journal | author=Sumara I, Vorlaufer E, Gieffers C, "et al." |title=Characterization of vertebrate cohesin complexes and their regulation in prophase. |journal=J. Cell Biol. |volume=151 |issue= 4 |pages= 749–62 |year= 2000 |pmid= 11076961 |doi=
*cite journal | author=Revenkova E, Eijpe M, Heyting C, "et al." |title=Novel meiosis-specific isoform of mammalian SMC1. |journal=Mol. Cell. Biol. |volume=21 |issue= 20 |pages= 6984–98 |year= 2001 |pmid= 11564881 |doi= 10.1128/MCB.21.20.6984-6998.2001
*cite journal | author=Gregson HC, Schmiesing JA, Kim JS, "et al." |title=A potential role for human cohesin in mitotic spindle aster assembly. |journal=J. Biol. Chem. |volume=276 |issue= 50 |pages= 47575–82 |year= 2002 |pmid= 11590136 |doi= 10.1074/jbc.M103364200
*cite journal | author=Andersen JS, Lyon CE, Fox AH, "et al." |title=Directed proteomic analysis of the human nucleolus. |journal=Curr. Biol. |volume=12 |issue= 1 |pages= 1–11 |year= 2002 |pmid= 11790298 |doi=
*cite journal | author=Kim ST, Xu B, Kastan MB |title=Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage. |journal=Genes Dev. |volume=16 |issue= 5 |pages= 560–70 |year= 2002 |pmid= 11877376 |doi= 10.1101/gad.970602
*cite journal | author=Yazdi PT, Wang Y, Zhao S, "et al." |title=SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint. |journal=Genes Dev. |volume=16 |issue= 5 |pages= 571–82 |year= 2002 |pmid= 11877377 |doi= 10.1101/gad.970702
*cite journal | author=Gregson HC, Van Hooser AA, Ball AR, "et al." |title=Localization of human SMC1 protein at kinetochores. |journal=Chromosome Res. |volume=10 |issue= 4 |pages= 267–77 |year= 2003 |pmid= 12199140 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Stewart GS, Wang B, Bignell CR, "et al." |title=MDC1 is a mediator of the mammalian DNA damage checkpoint. |journal=Nature |volume=421 |issue= 6926 |pages= 961–6 |year= 2003 |pmid= 12607005 |doi= 10.1038/nature01446
*cite journal | author=Wang Y, Qin J |title=MSH2 and ATR form a signaling module and regulate two branches of the damage response to DNA methylation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 26 |pages= 15387–92 |year= 2004 |pmid= 14657349 |doi= 10.1073/pnas.2536810100

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