Corepressor (genetics)

Corepressor (genetics)

A corepressor is a protein that decreases gene expression by binding to a transcription factor which contains a DNA binding domain. The corepressor is unable to bind DNA by itself. The corepressor can repress transcriptional initiation by recruiting histone deacetylases which catalyze the removal of acetyl groups from lysine residues. This increases the positive charge on histones which strengthens in the interaction between the histones and DNA, making the later less accessible to transcription.cite journal |author=Lazar MA|title=Nuclear receptor corepressors|journal= Nucl Recept Signal |volume= 1 |issue= Jun 12 |pages= e001 |year= 2003| doi = 10.1621/nrs.01001 |pmid= 16604174] cite journal |author=Goodson M, Jonas BA, Privalsky MA|title=Corepressors: custom tailoring and alterations while you wait|journal= Nucl Recept Signal |volume= 3 |issue= Oct 21 |pages= e003 |year= 2005| doi = 10.1621/nrs.03003 |pmid= 16604171]


ee also

*Transcription coregulator

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  • corepressor — corepressor. См. корепрессор. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • Corepressor — In molecular genetics, a corepressor is a substance that inhibits the expression of genes. A corepressor downregulates (or represses) the expression of genes not through direct interaction with a gene promoter (a sequence of DNA adjacent to the… …   Wikipedia

  • corepressor — /koh ri pres euhr/, n. Genetics. a molecule that is capable of combining with a specific repressor molecule and activating it, thereby blocking gene transcription. [1960 65; CO + REPRESSOR] * * * …   Universalium

  • corepressor — ˌkōˌ noun Etymology: co + repressor (herein) : a small molecule that activates a particular genetic repressor by combining with it * * * /koh ri pres euhr/, n. Genetics. a molecule that is capable of combining with a specific repressor molecule… …   Useful english dictionary

  • List of genetics-related topics — This is a list of terms related to genetics. NOTOC # * 3 end * 5 end A * Acentric chromosome * Achondroplasia * Active site * Adam s Curse * Adaptation * Adenine * Adenosine * Adenovirus * Adenosine diphosphate (ADP) * Ala * Alagille syndrome *… …   Wikipedia

  • Terminator (genetics) — In genetics, a terminator, or transcription terminator is a section of genetic sequence that marks the end of gene or operon on genomic DNA for transcription. In prokaryotes, two classes of transcription terminators are known: Intrinsic… …   Wikipedia

  • Coactivator (genetics) — A coactivator is a protein that increases gene expression by binding to an activator (or transcription factor) which contains a DNA binding domain. The coactivator is unable to bind DNA by itself.[1][2][3] The coactivator can enhance… …   Wikipedia

  • Transcription (genetics) — Transcription is the process of creating a complementary RNA copy of a sequence of DNA.[1] Both RNA and DNA are nucleic acids, which use base pairs of nucleotides as a complementary language that can be converted back and forth from DNA to RNA by …   Wikipedia

  • Enhancer (genetics) — In genetics, an enhancer is a short region of DNA that can be bound with proteins (namely, the trans acting factors, much like a set of transcription factors) to enhance transcription levels of genes (hence the name) in a gene cluster. While… …   Wikipedia

  • Insulator (genetics) — For electrical insulator, see Insulator (Electrical). For other uses, see Insulation (disambiguation). An insulator is a genetic boundary element that plays two distinct roles in gene expression, either as an enhancer blocking element, or more… …   Wikipedia

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