Centromere protein B


Centromere protein B
centromere protein B, 80kDa

PDB rendering based on 1bw6.
Identifiers
Symbol CENPB
External IDs OMIM117140 MGI88376 HomoloGene1370 GeneCards: CENPB Gene
Orthologs
Species Human Mouse
Entrez 1059 12616
Ensembl ENSG00000125817 ENSMUSG00000068267
UniProt P07199 P27790
RefSeq (mRNA) NM_001810 NM_007682
RefSeq (protein) NP_001801 NP_031708
Location (UCSC) Chr 20:
3.71 – 3.72 Mb
Chr 2:
131 – 131.01 Mb
PubMed search [1] [2]

Centromere protein B also known as major centromere autoantigen B is an autoantigen protein of the cell nucleus. In humans, centromere protein B is encoded by the CENPB gene.[1][2][3]

Contents

Function

Centromere protein B is a highly conserved protein that facilitates centromere formation. It is a DNA-binding protein that is derived from transposases of the pogo DNA transposon family. It contains a helix-loop-helix DNA binding motif at the N-terminus, and a dimerization domain at the C-terminus. The DNA binding domain recognizes and binds a 17-bp sequence (CENP-B box) in the centromeric alpha satellite DNA. This protein is proposed to play an important role in the assembly of specific centromere structures in interphase nuclei and on mitotic chromosomes. It is also considered a major centromere autoantigen recognized by sera from patients with anti-centromere antibodies.

Clinical significance

Centromere protein B is a potential biomarker of small-cell lung cancer.[4]

See also

References

  1. ^ "Entrez Gene: centromere protein B". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1059. 
  2. ^ Sugimoto K, Yata H, Himeno M (July 1993). "Mapping of the human CENP-B gene to chromosome 20 and the CENP-C gene to chromosome 12 by a rapid cycle DNA amplification procedure". Genomics 17 (1): 240–2. doi:10.1006/geno.1993.1312. PMID 8406460. 
  3. ^ Ando S, Yang H, Nozaki N, Okazaki T, Yoda K (April 2002). "CENP-A, -B, and -C chromatin complex that contains the I-type alpha-satellite array constitutes the prekinetochore in HeLa cells". Mol. Cell. Biol. 22 (7): 2229–41. doi:10.1128/MCB.22.7.2229-2241.2002. PMC 133672. PMID 11884609. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=133672. 
  4. ^ Briasoulis E, Kamposioras K, Tzovaras V, Pafitanis G, Kostoula A, Mavridis A, Pavlidis N (May 2008). "CENP-B specific anti-centromere autoantibodies heralding small-cell lung cancer. A case study and review of the literature". Lung Cancer 60 (2): 302–6. doi:10.1016/j.lungcan.2007.09.014. PMID 17980453. 

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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