Janus kinase 1

Janus kinase 1

JAK1 is essential for signaling for certain type I and type II cytokines. It interacts with the common gamma chain (γc) of type I cytokine receptors, to elicit signals from the IL-2 receptor family (e.g. IL-2R, IL-7R, IL-9R and IL-15R), the IL-4 receptor family (e.g. IL-4R and IL-13R), the gp130 receptor family (e.g. IL-6R, IL-11R, LIF-R, OSM-R, cardiotrophin-1 receptor (CT-1R), ciliary neurotrophic factor receptor (CNTF-R), neurotrophin-1 receptor (NNT-1R) and Leptin-R). It is also important for transducing a signal by type I (IFN-α/β) and type II (IFN-γ) interferons, and members of the IL-10 family via type II cytokine receptors.cite journal |author=Gadina M, Hilton D, Johnston JA, Morinobu A, Lighvani A, Zhou YJ, Visconti R, O'Shea JJ |title=Signaling by type I and II cytokine receptors: ten years after |journal=Curr. Opin. Immunol. |volume=13 |issue=3 |pages=363–73 |year=2001 |pmid=11406370 |doi=] Jak1 plays a critical role in initiating responses to multiple major cytokine receptor families. Loss of Jak1 is lethal in neonatal mice, possibly due to difficulties suckling.cite journal |author=Rodig SJ, Meraz MA, White JM, Lampe PA, Riley JK, Arthur CD, King KL, Sheehan KC, Yin L, Pennica D, Johnson EM, Schreiber RD |title=Disruption of the Jak1 gene demonstrates obligatory and nonredundant roles of the Jaks in cytokine-induced biologic responses |journal=Cell |volume=93 |issue=3 |pages=373–83 |year=1998 |pmid=9590172 |doi=]


Further reading

citations =
*cite journal | author=Donnelly RP, Dickensheets H, Finbloom DS |title=The interleukin-10 signal transduction pathway and regulation of gene expression in mononuclear phagocytes. |journal=J. Interferon Cytokine Res. |volume=19 |issue= 6 |pages= 563–73 |year= 1999 |pmid= 10433356 |doi= 10.1089/107999099313695
*cite journal | author=Carter-Su C, Rui L, Stofega MR |title=SH2-B and SIRP: JAK2 binding proteins that modulate the actions of growth hormone. |journal=Recent Prog. Horm. Res. |volume=55 |issue= |pages= 293–311 |year= 2000 |pmid= 11036942 |doi=
*cite journal | author=Kostrodymova GM |title= [An experimental study of the possible sensitizing properties of triethanolamine contained in chemical compounds used at home] |journal=Gigiena i sanitariia |volume= |issue= 6 |pages= 10–2 |year= 1976 |pmid= 1213395 |doi=
*cite journal | author=Howard OM, Dean M, Young H, "et al." |title=Characterization of a class 3 tyrosine kinase. |journal=Oncogene |volume=7 |issue= 5 |pages= 895–900 |year= 1992 |pmid= 1373877 |doi=
*cite journal | author=Pritchard MA, Baker E, Callen DF, "et al." |title=Two members of the JAK family of protein tyrosine kinases map to chromosomes 1p31.3 and 9p24. |journal=Mamm. Genome |volume=3 |issue= 1 |pages= 36–8 |year= 1992 |pmid= 1581631 |doi=
*cite journal | author=Wilks AF, Harpur AG, Kurban RR, "et al." |title=Two novel protein-tyrosine kinases, each with a second phosphotransferase-related catalytic domain, define a new class of protein kinase. |journal=Mol. Cell. Biol. |volume=11 |issue= 4 |pages= 2057–65 |year= 1991 |pmid= 1848670 |doi=
*cite journal | author=Johnston JA, Wang LM, Hanson EP, "et al." |title=Interleukins 2, 4, 7, and 15 stimulate tyrosine phosphorylation of insulin receptor substrates 1 and 2 in T cells. Potential role of JAK kinases. |journal=J. Biol. Chem. |volume=270 |issue= 48 |pages= 28527–30 |year= 1996 |pmid= 7499365 |doi=
*cite journal | author=Nicholson SE, Oates AC, Harpur AG, "et al." |title=Tyrosine kinase JAK1 is associated with the granulocyte-colony-stimulating factor receptor and both become tyrosine-phosphorylated after receptor activation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 8 |pages= 2985–8 |year= 1994 |pmid= 7512720 |doi=
*cite journal | author=Domanski P, Yan H, Witte MM, "et al." |title=Homodimerization and intermolecular tyrosine phosphorylation of the Tyk-2 tyrosine kinase. |journal=FEBS Lett. |volume=374 |issue= 3 |pages= 317–22 |year= 1995 |pmid= 7589562 |doi=
*cite journal | author=Modi WS, Farrar WL, Howard OM |title=Confirmed assignment of a novel human tyrosine kinase gene (JAK1A) to 1p32.3-->p31.3 by nonisotopic in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=69 |issue= 3-4 |pages= 232–4 |year= 1995 |pmid= 7698020 |doi=
*cite journal | author=Miyazaki T, Kawahara A, Fujii H, "et al." |title=Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits. |journal=Science |volume=266 |issue= 5187 |pages= 1045–7 |year= 1994 |pmid= 7973659 |doi=
*cite journal | author=Müller M, Briscoe J, Laxton C, "et al." |title=The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transduction. |journal=Nature |volume=366 |issue= 6451 |pages= 129–35 |year= 1993 |pmid= 8232552 |doi= 10.1038/366129a0
*cite journal | author=Lee ST, Strunk KM, Spritz RA |title=A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes. |journal=Oncogene |volume=8 |issue= 12 |pages= 3403–10 |year= 1993 |pmid= 8247543 |doi=
*cite journal | author=Lütticken C, Wegenka UM, Yuan J, "et al." |title=Association of transcription factor APRF and protein kinase Jak1 with the interleukin-6 signal transducer gp130. |journal=Science |volume=263 |issue= 5143 |pages= 89–92 |year= 1994 |pmid= 8272872 |doi=
*cite journal | author=Giorgetti-Peraldi S, Peyrade F, Baron V, Van Obberghen E |title=Involvement of Janus kinases in the insulin signaling pathway. |journal=Eur. J. Biochem. |volume=234 |issue= 2 |pages= 656–60 |year= 1996 |pmid= 8536716 |doi=
*cite journal | author=Friedmann MC, Migone TS, Russell SM, Leonard WJ |title=Different interleukin 2 receptor beta-chain tyrosines couple to at least two signaling pathways and synergistically mediate interleukin 2-induced proliferation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 5 |pages= 2077–82 |year= 1996 |pmid= 8700888 |doi=
*cite journal | author=Gauzzi MC, Velazquez L, McKendry R, "et al." |title=Interferon-alpha-dependent activation of Tyk2 requires phosphorylation of positive regulatory tyrosines by another kinase. |journal=J. Biol. Chem. |volume=271 |issue= 34 |pages= 20494–500 |year= 1996 |pmid= 8702790 |doi=
*cite journal | author=Demoulin JB, Uyttenhove C, Van Roost E, "et al." |title=A single tyrosine of the interleukin-9 (IL-9) receptor is required for STAT activation, antiapoptotic activity, and growth regulation by IL-9. |journal=Mol. Cell. Biol. |volume=16 |issue= 9 |pages= 4710–6 |year= 1996 |pmid= 8756628 |doi=
*cite journal | author=Yin T, Shen R, Feng GS, Yang YC |title=Molecular characterization of specific interactions between SHP-2 phosphatase and JAK tyrosine kinases. |journal=J. Biol. Chem. |volume=272 |issue= 2 |pages= 1032–7 |year= 1997 |pmid= 8995399 |doi=
*cite journal | author=Bluyssen HA, Levy DE |title=Stat2 is a transcriptional activator that requires sequence-specific contacts provided by stat1 and p48 for stable interaction with DNA. |journal=J. Biol. Chem. |volume=272 |issue= 7 |pages= 4600–5 |year= 1997 |pmid= 9020188 |doi=

External links


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