Poly(A)-binding protein


Poly(A)-binding protein

Poly(A)-binding protein is a RNA-binding protein which binds to the poly(A) tail of mRNA. The poly(A) tail is located on the 3' end of mRNA. The nuclear isoforms selectively binds to around 50 nucleotides and stimulates the activity of Polyadenylate polymerase.

The expression of mammalian Poly(A)-binding protein is regulated at the translational level by a feed-back mechanism: the mRNA encoding PABP contains in its 5' UTR an A-rich sequence which binds Poly(A)-binding protein. This leads to repression of translation

The cytosolic isoform of eukaryotes Poly(A) binding protein binds to the initiation factor eIF-4G via its C-terminal domain. EIF-4G is bound to eIF-4E, another initiation factor bound to the 5' cap on the 5' end of mRNA. This binding forms the characteristic loop structure of eukaryotic protein synthesis. Poly(A)-binding protein interacting proteins in the cytosol compete for the eIF-4G binding sites. Poly(A)-binding protein has also been shown to interact with a termination factor (eRF3)

Rotavirus NSP3

Rotavirus RNA-binding protein NSP3 interacts with eIF4GI and evicts the poly(A) binding protein from eIF4F. And NSP3A, by taking the place of PABP on eIF4GI, is responsible for the shut-off of cellular protein synthesis. cite journal|title=Rotavirus RNA-binding protein NSP3 interacts with eIF4GI and evicts the poly(A) binding protein from eIF4F.|journal=The EMBO journal|date=1998- Oct- 1|first=M|last=Piron|coauthors=P Vende, J Cohen, D Poncet|volume=17|issue=19|pages=5811-21|id=9755181 doi|10.1093/emboj/17.19.5811|url=http://view.ncbi.nlm.nih.gov/pubmed/9755181|accessdate=2007-11-02]

Genes

*, Gene|PABPC3, Gene|PABPC4, Gene|PABPC5

References

External links

*


Wikimedia Foundation. 2010.

Look at other dictionaries:

  • Poly(A)-Polymerase — alpha Masse/Länge Primärstruktur 744 Aminosäuren …   Deutsch Wikipedia

  • Poly(ADP-ribose)-Polymerase 1 — Poly (ADP ribose) polymerase 1 Struktur von PARP1 nach PDB  …   Deutsch Wikipedia

  • Protein K (porin) — Protein K is a porin expressed in some pathogenic strains of E. coli bacteria. It has a molecular weight of about 40 kDa and is localized to the outer membrane, through which it allows both inorganic and organic ions to pass. The strains in which …   Wikipedia

  • Poly-U-Experiment — Beim Poly U Experiment des US amerikanischen Biochemikers Marshall Nirenberg und dessen deutschem Post Doktoranden Heinrich Matthaei aus dem Jahre 1961[1] konnte erstmals eine genetische Codierungseinheit identifiziert werden – die Aminosäure… …   Deutsch Wikipedia

  • Poly(A)-Schwanz — Dieser Artikel oder Abschnitt ist nicht hinreichend mit Belegen (Literatur, Webseiten oder Einzelnachweisen) versehen. Die fraglichen Angaben werden daher möglicherweise demnächst gelöscht. Hilf Wikipedia, indem du die Angaben recherchierst und… …   Deutsch Wikipedia

  • Poly-A-Schwanz — Dieser Artikel oder Abschnitt ist nicht hinreichend mit Belegen (Literatur, Webseiten oder Einzelnachweisen) versehen. Die fraglichen Angaben werden daher möglicherweise demnächst gelöscht. Hilf Wikipedia, indem du die Angaben recherchierst und… …   Deutsch Wikipedia

  • poly(A) — noun Etymology: poly + adenylic acid Date: 1957 RNA or a segment of RNA that is composed of a polynucleotide chain consisting entirely of adenylic acid residues and that codes for polylysine when functioning as messenger RNA in protein synthesis …   New Collegiate Dictionary

  • poly(A) — polyadenylic acid * * * poly(A) päl ē ā n RNA or a segment of RNA that is composed of a polynucleotide chain consisting entirely of adenine containing nucleotides and that codes for polylysine when functioning as messenger RNA in protein… …   Medical dictionary

  • poly(A) — ¦pälēˈā noun ( s) Etymology: poly + adenylic acid : RNA or a segment of RNA that is composed of a polynucleotide chain consisting only of adenine containing nucleotides and that codes for polylysine when functioning as messenger RNA in protein… …   Useful english dictionary

  • poly(ADP-ribose) polymerase — (= PARP) (EC 2.4.2.30) An abundant nuclear protein activated by DNA nicks and important in DNA repair. PolyADP ribosylation, brought about by ADP ribosyl protein ligase, is a post transcriptional modification of proteins and p53 is one of the… …   Dictionary of molecular biology

  • D-alanine—poly(phosphoribitol) ligase — Identifiers EC number 6.1.1.13 CAS number 9023 65 8 …   Wikipedia


Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.