- Nizatidine
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Nizatidine 
Systematic (IUPAC) name N-(2-[(2-[(dimethylamino)methyl]thiazol-4-yl)methylthio]ethyl)-N-methyl-2-nitroethene-1,1-diamine Clinical data Trade names Axid AHFS/Drugs.com monograph MedlinePlus a694030 Licence data US FDA:link Pregnancy cat. B3(AU) Legal status Prescription Only (S4) (AU) POM (UK) OTC (US) Routes Oral Pharmacokinetic data Bioavailability >70% Protein binding 35% Metabolism Hepatic Half-life 1-2 hours Excretion Renal Identifiers CAS number 76963-41-2 
ATC code A02BA04 PubChem CID 3033637 DrugBank APRD00706 ChemSpider 2298266 UNII P41PML4GHR KEGG D00440 ChEMBL CHEMBL653 Chemical data Formula C12H21N5O2S2 Mol. mass 331.46 g/mol SMILES eMolecules & PubChem - InChI=1S/C12H21N5O2S2/c1-13-11(6-17(18)19)14-4-5-20-8-10-9-21-12(15-10)7-16(2)3/h6,9,13-14H,4-5,7-8H2,1-3H3/b11-6+
Key:SGXXNSQHWDMGGP-IZZDOVSWSA-N
(what is this?) (verify)Nizatidine is a histamine H2-receptor antagonist that inhibits stomach acid production, and commonly used in the treatment of peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD). It was developed by Eli Lilly and is marketed under the brand names Tazac and Axid.
Contents
Clinical use
Main article: H2-receptor antagonistCertain preparations of nizatidine are now available over the counter in various countries including the United States. Nizatidine has been used experimentally to control weight gain associated with some antipsychotic medication. [1]
History and development
Nizatidine was developed by Eli Lilly, and was first marketed in 1987. It is considered to be equipotent with ranitidine and differs by the substitution of a thiazole-ring in place of the furan-ring in ranitidine. In September 2000 Eli Lilly announced they would sell the sales and marketing rights for Axid to Reliant Pharmaceuticals. [2] Subsequently, Reliant developed the oral solution of Axid, marketing this in 2004, after gaining approval from the U.S. Food and Drug Administration (FDA). [3] However, a year later they sold rights of the Axid Oral Solution (including the issued patent US6,930,119 protecting the product) to Braintree Laboratories.[4]
Nizatidine proved to be the last new histamine H2-receptor antagonist introduced prior to the advent of proton pump inhibitors.
References
- ^ Atmaca M, Kuloglu M, Tezcan E, Ustundag B, Kilic N (January 2004). "Nizatidine for the treatment of patients with quetiapine-induced weight gain". Hum Psychopharmacol 19 (1): 37–40. doi:10.1002/hup.477. PMID 14716710.
- ^ Eli Lilly and Company and Reliant Pharmaceuticals Announce
- ^ Reliant Pharmaceuticals : Press Releases
- ^ Reliant Pharmaceuticals : Press Releases
External links
Drugs for acid related disorders: Drugs for peptic ulcer and GERD/GORD (A02B) H2 antagonists ("-tidine") Cimetidine • Famotidine • Lafutidine • Loxtidine • Niperotidine • Nizatidine • Ranitidine • RoxatidineProstaglandins (E)/analogues ("-prost-") Proton-pump inhibitors ("-prazole") Other Acetoxolone • Alginic acid • Carbenoxolone • Cetraxate • Gefarnate • Pirenzepine • Proglumide • Sucralfate • Sulglicotide • Teprenone • Troxipide • Zolimidine • Rebamipide •Categories:- H2 receptor antagonists
- Thiazoles
- Eli Lilly and Company
- Thioethers
- Nitroethenes
- InChI=1S/C12H21N5O2S2/c1-13-11(6-17(18)19)14-4-5-20-8-10-9-21-12(15-10)7-16(2)3/h6,9,13-14H,4-5,7-8H2,1-3H3/b11-6+
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