Oncostatin M receptor

Oncostatin M receptor
Identifiers
Symbols	OSMR; MGC150626; MGC150627; MGC75127; OSMRB
External IDs	OMIM: 601743 MGI: 1330819 HomoloGene: 2972 GeneCards: OSMR Gene
Gene Ontology Molecular function • receptor activity • oncostatin-M receptor activity • growth factor binding Cellular component • oncostatin-M receptor complex • membrane • integral to membrane Biological process • positive regulation of acute inflammatory response • cell surface receptor linked signaling pathway • cell proliferation • positive regulation of cell proliferation • response to cytokine stimulus Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9180	18414
Ensembl	ENSG00000145623	ENSMUSG00000022146
UniProt	Q99650	O70458
RefSeq (mRNA)	NM_001168355.1	NM_011019.3
RefSeq (protein)	NP_001161827.1	NP_035149.2
Location (UCSC)	Chr 5: 38.85 – 38.95 Mb	Chr 15: 6.76 – 6.82 Mb
PubMed search	[1]	[2]

Oncostatin-M specific receptor subunit beta also known as the oncostatin M receptor, is one of the receptor proteins for oncostatin M, that in humans is encoded by the OSMR gene.^[1][2]

OSMR is a member of the type I cytokine receptor family. This protein heterodimerizes with interleukin 6 signal transducer to form the type II oncostatin M receptor and with interleukin 31 receptor A to form the interleukin 31 receptor, and thus transduces oncostatin M and interleukin 31 induced signaling events.^[1]

Clinical significance

The oncostatin M receptor is associated with primary cutaneous amyloidosis.^[3]

References

1. ^ ^{a b} "Entrez Gene: oncostatin M receptor". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9180. 
2. ^ Mosley B, De Imus C, Friend D, Boiani N, Thoma B, Park LS, Cosman D (December 1996). "Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation". J. Biol. Chem. 271 (51): 32635–43. doi:10.1074/jbc.271.51.32635. PMID 8999038. 
3. ^ Arita K, South AP, Hans-Filho G, et al (January 2008). "Oncostatin M Receptor-β Mutations Underlie Familial Primary Localized Cutaneous Amyloidosis". Am. J. Hum. Genet. 82 (1): 73–80. doi:10.1016/j.ajhg.2007.09.002. PMC 2253984. PMID 18179886. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2253984. 

External links

• MeSH Oncostatin+M+Receptor

This article incorporates text from the United States National Library of Medicine, which is in the public domain.