Spin label

Spin label

A spin label (SL) is an organic molecule which possesses an unpaired electron, usually on a nitrogen atom, and the ability to bind to another molecule. Spin labels are normally used as tools for probing proteins or biological membrane-local dynamics using EPR spectroscopy. The site-directed spin labeling (SDSL) technique allows one to monitor a specific region within a protein. In protein structure examinations, amino acid-specific SLs can be used.

The goal of spin labeling is somewhat similar to that of isotopic substitution in NMR spectroscopy. There one replaces an atom lacking a nuclear spin (and so is NMR-silent) with an isotope having a spin I eq 0 (and so is NMR-active). This technique is useful for tracking the chemical environment around an atom when full substitution with an NMR-active isotope is not feasible. Recently, spin-labelling has also been used to probe chemical local environment in NMR itself, in a technique known as Paramagnetic Relaxation Enhancement (PRE).


Berliner, L.J. (1976). Spin labeling I : theory and applications, Academic Press, New York.

Berliner, L.J. (1979). Spin labeling II : theory and applications, Academic Press, New York.

Wikimedia Foundation. 2010.

Look at other dictionaries:

  • spin label — n a chemical species (as a free radical or metal complex) that has an unpaired electron and that is introduced into a molecule so that the molecule can be investigated using electron spin resonance spin la·beled or spin la·belled adj spin… …   Medical dictionary

  • Spin Label — Spịn La|bel [ leɪbl; ↑ Spin u. ↑ Label] ↑ Spinmarkierung …   Universal-Lexikon

  • spin label — noun An organic compound, containing an unpaired electron spin, that can be bonded to a molecule under investigation so as to be analysed using electron spin resonance spectroscopy …   Wiktionary

  • SPIN — skeletal plan instantiation; Social Phobia Inventory * * * spin spin n 1) a quantum characteristic of an elementary particle that is visualized as the rotation of the particle on its axis and that is responsible for measurable angular momentum… …   Medical dictionary

  • spin — spine, spinal * * * spin spin n 1) a quantum characteristic of an elementary particle that is visualized as the rotation of the particle on its axis and that is responsible for measurable angular momentum and magnetic moment 2) the angular… …   Medical dictionary

  • Spin probe — A spin probe is a molecule with stable free radical character that carries a functional group. This group can be used to couple the probe to another molecule, e.g. a biomolecule. Electron spin resonance can be employed to quantify the probe s… …   Wikipedia

  • Spin Records — was an Australian popular music label of the late 1960s and early 1970s. It was established in late 1966 by Clyde Packer and a group of partners including entrepreneur Harry M. Miller. The label s first A R manager was Nat Kipner (who is the… …   Wikipedia

  • Spin The Music — Album par Crystal Kay Sortie 8 décembre 2010 Durée 51:24 Genre …   Wikipédia en Français

  • Spin Aqua — were a short lived indies musical project between the model Anna Tsuchiya and the former Oblivion Dust guitarist K.A.Z. The duo performed music together for a year and seven months; releasing music for less than a year under the indies label… …   Wikipedia

  • Spin Me a Christmas — Single par Aqua extrait de l’album Greatest Hits Durée 3 min 33 s Genre Dance Label Universal …   Wikipédia en Français

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.