Glutamate formimidoyltransferase
- Glutamate formimidoyltransferase
Glutamate formimidoyltransferase is a methyltransferase enzyme which uses tetrahydrofolate as part of histidine catabolism. It catalyses two reactions:
* 5-formimidoyltetrahydrofolate + L-glutamate <=> tetrahydrofolate + N-formimidoyl-L-glutamate
* 5-formyltetrahydrofolate + L-glutamate <=> tetrahydrofolate + N-formyl-L-glutamate
It is classified under EC number|2.1.2.5 and in mammals is found as part of a bifunctional enzyme that also has formimidoyltetrahydrofolate cyclodeaminase activity. [cite journal |author=MacKenzie RE, Aldridge M, Paquin J |title=The bifunctional enzyme formiminotransferase-cyclodeaminase is a tetramer of dimers |journal=J. Biol. Chem. |volume=255 |issue=19 |pages=9474–8 |year=1980 |pmid=7410436 |url=http://www.jbc.org/cgi/reprint/255/19/9474]
References
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