Mir-26 microRNA precursor family

The miR-26 microRNA precursor is a small non-coding RNA that is involved in regulating gene expression. miR-26 appears to be a vertebrate specific microRNA [cite journal | last = Lagos-Quintana | first = M | coauthors = Rauhut R, Lendeckel W, Tuschl T | year = 2001 | title = Identification of novel genes coding for small expressed RNAs | journal = Science | volume = 294 | pages = 853–858 | pmid = 11679670 | doi = 10.1126/science.1064921] [cite journal | last = Lagos-Quintana | first = M | coauthors = Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T | year = 2002 | title = Identification of tissue-specific microRNAs from mouse | journal = Curr Biol | volume = 12 | pages = 735–739 | pmid = 12007417 | doi = 10.1016/S0960-9822(02)00809-6] and has now been predicted or experimentally validated in many vertebrate species ( [http://microrna.sanger.ac.uk/cgi-bin/sequences/mirna_summary.pl?fam=MIPF0000043 MIPF0000043] ). In this microRNA the mature sequence is excised from the 5' arm of the hairpin. miR-26 has been shown to be expressed in neural tissue.cite journal |author=Smirnova L, Gräfe A, Seiler A, Schumacher S, Nitsch R, Wulczyn FG |title=Regulation of miRNA expression during neural cell specification |journal=Eur. J. Neurosci. |volume=21 |issue=6 |pages=1469–77 |year=2005 |pmid=15845075 |doi=10.1111/j.1460-9568.2005.03978.x |issn=] It has also been suggested that miR-26 is involved in response to low oxygen levels.cite journal |author=Kulshreshtha R, Ferracin M, Wojcik SE, "et al" |title=A microRNA signature of hypoxia |journal=Mol. Cell. Biol. |volume=27 |issue=5 |pages=1859–67 |year=2007 |pmid=17194750 |doi=10.1128/MCB.01395-06 |issn=]

References

External links

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* [http://microrna.sanger.ac.uk/cgi-bin/sequences/mirna_summary.pl?fam=MIPF0000043 MIPF0000043]