Mesothelin

Mesothelin
Mesothelin
Identifiers
Symbols MSLN; MPF; SMRP
External IDs OMIM601051 MGI1888992 HomoloGene4249 GeneCards: MSLN Gene
Orthologs
Species Human Mouse
Entrez 10232 56047
Ensembl ENSG00000102854 ENSMUSG00000063011
UniProt Q13421 Q61468
RefSeq (mRNA) NM_001177355.1 NM_018857.1
RefSeq (protein) NP_001170826.1 NP_061345.1
Location (UCSC) Chr 16:
0.69 – 0.82 Mb
Chr 17:
25.89 – 25.89 Mb
PubMed search [1] [2]

Mesothelin also known as MSLN is a protein that in humans is encoded by the MSLN gene.[1][2]

Contents

Function

Mesothelin is a 40kDa protein present on normal mesothelial cells and overexpressed in several human tumors, including mesothelioma and ovarian and pancreatic adenocarcinoma. The protein was first identified by its reactivity with monoclonal antibody K1.[3] Subsequent cloning studies showed that the mesothelin gene encodes a precursor protein that is processed to yield mesothelin which is attached to the cell membrane by a glycophosphatidylinositol linkage and a 31-kDa shed fragment named megakaryocyte-potentiating factor (MPF). Although it has been proposed that mesothelin may be involved in cell adhesion, its biological function is not known.[4]

Therapeutic application

Mesothelin is a tumour differentiation antigen that is normally present on the mesothelial cells lining the pleura, peritoneum and pericardium.[5] Since mesothelin is overexpressed in several cancers and is immunogenic, the protein could be exploited as tumor marker or as the antigenic target of a therapeutic cancer vaccine.[4][5]

References

  1. ^ Kojima T, Oh-eda M, Hattori K, Taniguchi Y, Tamura M, Ochi N, Yamaguchi N (September 1995). "Molecular cloning and expression of megakaryocyte potentiating factor cDNA". J. Biol. Chem. 270 (37): 21984–90. doi:10.1074/jbc.270.37.21984. PMID 7665620. http://www.jbc.org/cgi/pmidlookup?view=long&pmid=7665620. 
  2. ^ Chang K, Pastan I (January 1996). "Molecular cloning of mesothelin, a differentiation antigen present on mesothelium, mesotheliomas, and ovarian cancers". Proc. Natl. Acad. Sci. U.S.A. 93 (1): 136–40. doi:10.1073/pnas.93.1.136. PMC 40193. PMID 8552591. http://www.pnas.org/cgi/pmidlookup?view=long&pmid=8552591. 
  3. ^ Chang K, Pai LH, Batra JK, Pastan I, Willingham MC (January 1992). "Characterization of the Antigen (CAK1) Recognized by Monoclonal Antibody K1 Present on Ovarian Cancers and Normal Mesothelium". Cancer Res 52 (1): 181–6. PMID 1727378. 
  4. ^ a b Hassan R, Bera T, Pastan I (June 2004). "Mesothelin: a new target for immunotherapy". Clin. Cancer Res. 10 (12 Pt 1): 3937–42. doi:10.1158/1078-0432.CCR-03-0801. PMID 15217923. 
  5. ^ a b Hassan R, Ho M (January 2008). "Mesothelin targeted cancer immunotherapy". Eur. J. Cancer 44 (1): 46–53. doi:10.1016/j.ejca.2007.08.028. PMC 2265108. PMID 17945478. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2265108. 

Further reading



Wikimedia Foundation. 2010.

Игры ⚽ Нужен реферат?

Look at other dictionaries:

  • mesothelin — A protein found on the surface of certain types of normal cells and cancer cells. Mesothelin may help these cells stick together and send signals. A higher than normal amount of mesothelin is found on some cancer cells, including mesothelioma,… …   English dictionary of cancer terms

  • Anti-mesothelin monoclonal antibody MORAb-009 — is a monoclonal antibody being studied in the treatment of some types of cancer. Monoclonal antibodies are made in the laboratory and can locate and bind to substances in the body, including cancer cells. Anti mesothelin monoclonal antibody MORAb …   Wikipedia

  • anti-mesothelin monoclonal antibody MORAb-009 — A monoclonal antibody being studied in the treatment of some types of cancer. Monoclonal antibodies are made in the laboratory and can locate and bind to substances in the body, including cancer cells. Anti mesothelin monoclonal antibody MORAb… …   English dictionary of cancer terms

  • Mesothelioma — Classification and external resources Left sided mesothelioma with mediastinal node enlargement : CT scan. ICD 10 C …   Wikipedia

  • Malignant pleural effusion — is a condition in which cancer causes an abnormal amount of fluid to collect between the thin layers of tissue (pleura) lining the outside of the lung and the wall of the chest cavity. Lung cancer and breast cancer account for about 50 65% of… …   Wikipedia

  • Cancer de la plèvre — Mésothéliome Mésothéliome CIM 10 : C45 Le mésothéliome est une forme rare et virulente de cancer des surfaces mésothéliales qui affecte le revêtement des poumons (la plèvre), de la cavité abdominale (le péritoine) ou l enveloppe du cœur (le… …   Wikipédia en Français

  • Mesotheliome — Mésothéliome Mésothéliome CIM 10 : C45 Le mésothéliome est une forme rare et virulente de cancer des surfaces mésothéliales qui affecte le revêtement des poumons (la plèvre), de la cavité abdominale (le péritoine) ou l enveloppe du cœur (le… …   Wikipédia en Français

  • Mésothéliome — Classification internationale des maladies CIM 10 : C45 Scan thoracique montrant un mésothéliome dans le poumon droit (à gauche dans l image) …   Wikipédia en Français

  • MORAb-009 — A monoclonal antibody being studied in the treatment of some types of cancer. Monoclonal antibodies are made in the laboratory and can locate and bind to substances in the body, including cancer cells. MORAb 009 binds to mesothelin (a protein… …   English dictionary of cancer terms

  • CA-125 — For the highway, see California State Route 125. Mucin 16, cell surface associated Identifiers Symbols MUC16; CA125; FLJ14303 External IDs …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”