- Carboxypeptidase A
Carboxypeptidase A usually refers to the
pancreatic exopeptidasewhich hydrolyzes peptide bondsof C-terminal residues with aromaticor aliphatic side chains. Most scientists in the field now refer to this enzyme as Gene|CPA1, and to a related pancreatic carboxypeptidaseas Gene|CPA2.
In addition, there are 4 other mammalian enzymes named CPA-3 through CPA-6, and none of these are expressed in the pancreas. Instead, these other CPA-like enzymes have diverse functions.
* (also known as mast-cell CPA) is involved in the digestion of proteins by
* (previously known as CPA-3, but renumbered when mast-cell CPA was designated CPA-3) may be involved in
tumorprogression, but this enzyme has not been well studied.
* and Gene|CPA6 have also not been well studied. Interestingly, a human mutation of CPA-6 is known to cause
Duane's syndrome(abnormal eye movement). This, together with the localization of CPA-6 to embryonic eye muscle (in addition to other limited locations) suggests a role for CPA-6 in the control of neuronal migration/axonal guidance.
CPA-1 and CPA-2 (and presumably all other CPAs) contain a
zincatom at the active site. Loss of the zinc leads to loss of activity, which can be replaced easily by zinc, and also by some other divalentmetals ( cobalt, nickel).
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Carboxypeptidase E — Carboxypeptidase E, also known as CPE, is a human gene.cite web | title = Entrez Gene: CPE carboxypeptidase E| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=1363| accessdate = ] PBB Summary section title … Wikipedia
Carboxypeptidase — (EC number 3.4.16 3.4.18) is an enzyme that hydrolyzes the carboxy terminal (C terminal) end of a peptide bond. Humans, animals, and plants contain several types of carboxypeptidases with diverse functions ranging from catabolism to protein… … Wikipedia
Carboxypeptidase B2 — (plasma) Rendering based on PDB 3D66 … Wikipedia
Carboxypeptidase A2 — (pancreatic), also known as CPA2, is a human gene.cite web | title = Entrez Gene: CPA2 carboxypeptidase A2 (pancreatic)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=1358| accessdate = ] PBB Summary… … Wikipedia
Carboxypeptidase — Carboxypeptidasen Enzymklassifikation EC, Kategorie … Deutsch Wikipedia
Carboxypeptidase B — protein Name=carboxypeptidase B1 (tissue) caption= width= HGNCid=2299 Symbol=CPB1 AltSymbols= EntrezGene=1360 OMIM=114852 RefSeq=NM 001871 UniProt=P15086 PDB= ECnumber=188.8.131.52 Chromosome=3 Arm=q Band=24 LocusSupplementaryData=protein… … Wikipedia
carboxypeptidase — Enzymes (particularly of pancreas) that remove the C terminal amino acid from a protein or peptide. Carboxypeptidase A, (EC 184.108.40.206) will remove any amino acid; carboxypeptidase B (EC 220.127.116.11) is specific for terminal lysine or arginine … Dictionary of molecular biology
carboxypeptidase C — See serine carboxypeptidase … Medical dictionary
carboxypeptidase — karboksipeptidazė statusas T sritis chemija apibrėžtis Fermentas, atskeliantis C galines aminorūgštis. atitikmenys: angl. carboxypeptidase rus. карбоксипептидаза … Chemijos terminų aiškinamasis žodynas
carboxypeptidase — noun Date: 1935 an enzyme that hydrolyzes peptides and especially polypeptides by splitting off sequentially the amino acids at the end of the peptide chain which contain free carboxyl groups … New Collegiate Dictionary