Carboxypeptidase A


Carboxypeptidase A

Carboxypeptidase A usually refers to the pancreatic exopeptidase which hydrolyzes peptide bonds of C-terminal residues with aromatic or aliphatic side chains. Most scientists in the field now refer to this enzyme as Gene|CPA1, and to a related pancreatic carboxypeptidase as Gene|CPA2.

In addition, there are 4 other mammalian enzymes named CPA-3 through CPA-6, and none of these are expressed in the pancreas. Instead, these other CPA-like enzymes have diverse functions.
* (also known as mast-cell CPA) is involved in the digestion of proteins by mast cells.
* (previously known as CPA-3, but renumbered when mast-cell CPA was designated CPA-3) may be involved in tumor progression, but this enzyme has not been well studied.
* and Gene|CPA6 have also not been well studied. Interestingly, a human mutation of CPA-6 is known to cause Duane's syndrome (abnormal eye movement). This, together with the localization of CPA-6 to embryonic eye muscle (in addition to other limited locations) suggests a role for CPA-6 in the control of neuronal migration/axonal guidance.

CPA-1 and CPA-2 (and presumably all other CPAs) contain a zinc atom at the active site. Loss of the zinc leads to loss of activity, which can be replaced easily by zinc, and also by some other divalent metals (cobalt, nickel).

External links

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Look at other dictionaries:

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  • Carboxypeptidase B2 — (plasma) Rendering based on PDB 3D66 …   Wikipedia

  • Carboxypeptidase A2 — (pancreatic), also known as CPA2, is a human gene.cite web | title = Entrez Gene: CPA2 carboxypeptidase A2 (pancreatic)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=1358| accessdate = ] PBB Summary… …   Wikipedia

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  • carboxypeptidase — Enzymes (particularly of pancreas) that remove the C terminal amino acid from a protein or peptide. Carboxypeptidase A, (EC 3.4.17.1) will remove any amino acid; carboxypeptidase B (EC 3.4.17.2) is specific for terminal lysine or arginine …   Dictionary of molecular biology

  • carboxypeptidase C — See serine carboxypeptidase …   Medical dictionary

  • carboxypeptidase — karboksipeptidazė statusas T sritis chemija apibrėžtis Fermentas, atskeliantis C galines aminorūgštis. atitikmenys: angl. carboxypeptidase rus. карбоксипептидаза …   Chemijos terminų aiškinamasis žodynas

  • carboxypeptidase — noun Date: 1935 an enzyme that hydrolyzes peptides and especially polypeptides by splitting off sequentially the amino acids at the end of the peptide chain which contain free carboxyl groups …   New Collegiate Dictionary


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