Caspase 4


Caspase 4

protein
Name = caspase 4, apoptosis-related cysteine peptidase
caption =


width = 240px
HGNCid = 1505
Symbol = CASP4
AltSymbols = ICE(rel)II, ICH-2, TX
EntrezGene = 837
OMIM = 602664
RefSeq = NM_001225
UniProt = P49662
PDB =
ECnumber = 3.4.22.57
Chromosome = 11
Arm = q
Band = 22.2-q22.3
LocusSupplementaryData =

Caspase 4 is an enzyme that proteolytically cleaves other proteins at an aspartic acid residue, and belongs to a family of cysteine proteases called caspases. The function of caspase 4 is not fully known, but it is believed to be an inflammatory caspase, along with caspase 1, caspase 5 (and the murine homolog caspase 11), with a role in the immune system. [cite journal |author=Martinon F, Tschopp J |title=Inflammatory caspases and inflammasomes: master switches of inflammation |journal=Cell Death Differ. |volume=14 |issue=1 |pages=10–22 |year=2007 |pmid=16977329 |doi=10.1038/sj.cdd.4402038]

References


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