CD137

CD137 is a member of the tumor necrosis factor (TNF) receptor family. Its alternative names are "tumor necrosis factor receptor superfamily member 9" (TNFRSF9), "4-1BB" and "induced by lymphocyte activation" (ILA).

Expression

CD137 can be expressed by activated T cells, but to a larger extent on CD8 than on CD4 T cells. In addition, CD137 expression is found on dendritic cells, follicular dendritic cells, natural killer cells, granulocytes and cells of blood vessel walls at sites of inflammation.

Specific effects on cells

The best characterized activity of CD137 is its costimulatory activity for activated T cells. Crosslinking of CD137 enhances T cell proliferation, IL-2 secretion survival and cytolytic activity. Further, it can enhance immune activity to eliminate tumors in mice.

ee also

* 4-1BB ligand

References

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Further reading

PBB_Further_reading
citations =
*cite journal | author=Sica G, Chen L |title=Biochemical and immunological characteristics of 4-1BB (CD137) receptor and ligand and potential applications in cancer therapy. |journal=Arch. Immunol. Ther. Exp. (Warsz.) |volume=47 |issue= 5 |pages= 275–9 |year= 2000 |pmid= 10604232 |doi=
*cite journal | author=Schwarz H |title=Biological activities of reverse signal transduction through CD137 ligand. |journal=J. Leukoc. Biol. |volume=77 |issue= 3 |pages= 281–6 |year= 2005 |pmid= 15618293 |doi= 10.1189/jlb.0904558
*cite journal | author=Kwon BS, Weissman SM |title=cDNA sequences of two inducible T-cell genes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=86 |issue= 6 |pages= 1963–7 |year= 1989 |pmid= 2784565 |doi=
*cite journal | author=Zhou Z, Kim S, Hurtado J, "et al." |title=Characterization of human homologue of 4-1BB and its ligand. |journal=Immunol. Lett. |volume=45 |issue= 1-2 |pages= 67–73 |year= 1995 |pmid= 7622190 |doi=
*cite journal | author=Alderson MR, Smith CA, Tough TW, "et al." |title=Molecular and biological characterization of human 4-1BB and its ligand. |journal=Eur. J. Immunol. |volume=24 |issue= 9 |pages= 2219–27 |year= 1994 |pmid= 8088337 |doi=
*cite journal | author=Schwarz H, Tuckwell J, Lotz M |title=A receptor induced by lymphocyte activation (ILA): a new member of the human nerve-growth-factor/tumor-necrosis-factor receptor family. |journal=Gene |volume=134 |issue= 2 |pages= 295–8 |year= 1994 |pmid= 8262389 |doi=
*cite journal | author=Schwarz H, Blanco FJ, von Kempis J, "et al." |title=ILA, a member of the human nerve growth factor/tumor necrosis factor receptor family, regulates T-lymphocyte proliferation and survival. |journal=Blood |volume=87 |issue= 7 |pages= 2839–45 |year= 1996 |pmid= 8639902 |doi=
*cite journal | author=Loo DT, Chalupny NJ, Bajorath J, "et al." |title=Analysis of 4-1BBL and laminin binding to murine 4-1BB, a member of the tumor necrosis factor receptor superfamily, and comparison with human 4-1BB. |journal=J. Biol. Chem. |volume=272 |issue= 10 |pages= 6448–56 |year= 1997 |pmid= 9045669 |doi=
*cite journal | author=Schwarz H, Arden K, Lotz M |title=CD137, a member of the tumor necrosis factor receptor family, is located on chromosome 1p36, in a cluster of related genes, and colocalizes with several malignancies. |journal=Biochem. Biophys. Res. Commun. |volume=235 |issue= 3 |pages= 699–703 |year= 1997 |pmid= 9207223 |doi= 10.1006/bbrc.1997.6870
*cite journal | author=Arch RH, Thompson CB |title=4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor kappaB. |journal=Mol. Cell. Biol. |volume=18 |issue= 1 |pages= 558–65 |year= 1998 |pmid= 9418902 |doi=
*cite journal | author=Jang IK, Lee ZH, Kim YJ, "et al." |title=Human 4-1BB (CD137) signals are mediated by TRAF2 and activate nuclear factor-kappa B. |journal=Biochem. Biophys. Res. Commun. |volume=242 |issue= 3 |pages= 613–20 |year= 1998 |pmid= 9464265 |doi= 10.1006/bbrc.1997.8016
*cite journal | author=Kim YJ, Kim SH, Mantel P, Kwon BS |title=Human 4-1BB regulates CD28 co-stimulation to promote Th1 cell responses. |journal=Eur. J. Immunol. |volume=28 |issue= 3 |pages= 881–90 |year= 1998 |pmid= 9541583 |doi=
*cite journal | author=Saoulli K, Lee SY, Cannons JL, "et al." |title=CD28-independent, TRAF2-dependent costimulation of resting T cells by 4-1BB ligand. |journal=J. Exp. Med. |volume=187 |issue= 11 |pages= 1849–62 |year= 1998 |pmid= 9607925 |doi=
*cite journal | author=Langstein J, Michel J, Schwarz H |title=CD137 induces proliferation and endomitosis in monocytes. |journal=Blood |volume=94 |issue= 9 |pages= 3161–8 |year= 1999 |pmid= 10556203 |doi=
*cite journal | author=Jang LK, Lee ZH, Kim HH, "et al." |title=A novel leucine-rich repeat protein (LRR-1): potential involvement in 4-1BB-mediated signal transduction. |journal=Mol. Cells |volume=12 |issue= 3 |pages= 304–12 |year= 2002 |pmid= 11804328 |doi=
*cite journal | author=Cooper D, Bansal-Pakala P, Croft M |title=4-1BB (CD137) controls the clonal expansion and survival of CD8 T cells in vivo but does not contribute to the development of cytotoxicity. |journal=Eur. J. Immunol. |volume=32 |issue= 2 |pages= 521–9 |year= 2002 |pmid= 11828369 |doi=
*cite journal | author=Wilcox RA, Chapoval AI, Gorski KS, "et al." |title=Cutting edge: Expression of functional CD137 receptor by dendritic cells. |journal=J. Immunol. |volume=168 |issue= 9 |pages= 4262–7 |year= 2002 |pmid= 11970964 |doi=
*cite journal | author=Shulzhenko N, Morgun A, Chinellato AP, "et al." |title=CD27 but not CD70 and 4-1BB intragraft gene expression is a risk factor for acute cardiac allograft rejection in humans. |journal=Transplant. Proc. |volume=34 |issue= 2 |pages= 474–5 |year= 2002 |pmid= 12009595 |doi=
*cite journal | author=Pauly S, Broll K, Wittmann M, "et al." |title=CD137 is expressed by follicular dendritic cells and costimulates B lymphocyte activation in germinal centers. |journal=J. Leukoc. Biol. |volume=72 |issue= 1 |pages= 35–42 |year= 2002 |pmid= 12101260 |doi=

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