Glycerol-3-phosphate dehydrogenase


Glycerol-3-phosphate dehydrogenase

protein
Name=glycerol-3-phosphate dehydrogenase 1 (soluble)
caption=



width=
HGNCid=4455
Symbol=GPD1
AltSymbols=
EntrezGene=2819
OMIM=138420
RefSeq=NM_005276
UniProt=P21695
PDB=
ECnumber=1.1.1.8
Chromosome=12
Arm=q
Band=12
LocusSupplementaryData=-q13
protein
Name=glycerol-3-phosphate dehydrogenase 2 (mitochondrial)
caption=


width=
HGNCid=4456
Symbol=GPD2
AltSymbols=
EntrezGene=2820
OMIM=138430
RefSeq=NM_000408
UniProt=P43304
PDB=
ECnumber=1.1.1.8
Chromosome=2
Arm=q
Band=24.1
LocusSupplementaryData=

Glycerol-3-phosphate dehydrogenase (GPDH) is an enzyme that catalyzes the oxidation of sn-glycerol 3-phosphate to dihydroxyacetone phosphate (aka glycerone phosphate, outdated).

Older terms for glycerol-3-phosphate dehydrogenase include "alpha glycerol-3-phosphate dehydrogenase" (alphaGPDH) and "glycerolphosphate dehydrogenase" (GPDH). However, glycerol-3-phosphate dehydrogenase is not the same as glyceraldehyde 3-phosphate dehydrogenase (GAPDH) whose substrate is an aldehyde not an alcohol.

Reaction

The reaction catalyzed by cytosolic GPDH is as follows:



Glycerol-3-phosphate shuttle

The cytosolic together with the mitochondrial glycerol-3-phosphate dehydrogenase work in concert. Oxidation of cytoplasmic NADH by the cytosolic form of the enzyme creates glycerol-3-phosphate from dihydroxyacetone phosphate. Once the Glycerol-3-phosphate has moved through the Outer Mitochondrial Membrane it can then be oxidised by a separate isoform of glycerol-3-phosphate dehydrogenase. This differ as it is instead FADH2 linked. As a result there is a net loss in energy, comparable to 1 ATP. Illustrated here [http://www.ncbi.nlm.nih.gov/books/bv.fcgi?highlight=glycerol-3-phosphate%20dehydrogenase&rid=stryer.figgrp.2548] .

ee also

* substrate pages: glycerol 3-phosphate, dihydroxyacetone phosphate
* related topics: glycerol phosphate shuttle, creatine kinase, glycolysis, gluconeogenesis

External links

* equivalent entries: MeshName|alphaGPDH and [http://www.ncbi.nlm.nih.gov/sites/entrez?Db=mesh&Cmd=ShowDetailView&TermToSearch=68050536 GPDH]

References

External links

* Yeast genome database GO term: [http://db.yeastgenome.org/cgi-bin/GO/goTerm.pl?goid=4367 GPDH]
* enzyme no. GPnotebook|-2053504966


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