- Glycerol-3-phosphate dehydrogenase
Name=glycerol-3-phosphate dehydrogenase 1 (soluble)
Name=glycerol-3-phosphate dehydrogenase 2 (mitochondrial)
Glycerol-3-phosphate dehydrogenase (GPDH) is an enzyme that catalyzes the oxidation of sn-
glycerol 3-phosphateto dihydroxyacetone phosphate(aka glycerone phosphate, outdated).
Older terms for glycerol-3-phosphate dehydrogenase include "alpha glycerol-3-phosphate dehydrogenase" (alphaGPDH) and "glycerolphosphate dehydrogenase" (GPDH). However, glycerol-3-phosphate dehydrogenase is not the same as
glyceraldehyde 3-phosphate dehydrogenase(GAPDH) whose substrate is an aldehydenot an alcohol.
The reaction catalyzed by cytosolic GPDH is as follows:
The cytosolic together with the mitochondrial glycerol-3-phosphate dehydrogenase work in concert. Oxidation of cytoplasmic
NADHby the cytosolic form of the enzyme creates glycerol-3-phosphatefrom dihydroxyacetone phosphate. Once the Glycerol-3-phosphate has moved through the Outer Mitochondrial Membraneit can then be oxidised by a separate isoform of glycerol-3-phosphate dehydrogenase. This differ as it is instead FADH2linked. As a result there is a net loss in energy, comparable to 1 ATP. Illustrated here [http://www.ncbi.nlm.nih.gov/books/bv.fcgi?highlight=glycerol-3-phosphate%20dehydrogenase&rid=stryer.figgrp.2548] .
* substrate pages:
glycerol 3-phosphate, dihydroxyacetone phosphate
* related topics:
glycerol phosphate shuttle, creatine kinase, glycolysis, gluconeogenesis
* equivalent entries: MeshName|alphaGPDH and [http://www.ncbi.nlm.nih.gov/sites/entrez?Db=mesh&Cmd=ShowDetailView&TermToSearch=68050536 GPDH]
* Yeast genome database GO term: [http://db.yeastgenome.org/cgi-bin/GO/goTerm.pl?goid=4367 GPDH]
* enzyme no. GPnotebook|-2053504966
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