Hairy leukoplakia

Hairy leukoplakia
Classification and external resources
ICD-10	K13.3
ICD-9	528.6
DiseasesDB	5594
eMedicine	med/938
MeSH	D017733

Hairy leukoplakia (also known as "oral hairy leukoplakia"^[1]:385) is a white patch on the side of the tongue with a corrugated or hairy appearance.

Causes

Hairy leukoplakia is seen in severe defects of immunity, particularly in HIV infection. The cause of this condition is an opportunistic infection by the Epstein-Barr virus (EBV). After the primary EBV infection has been overcome, the virus stays latent in the B cells and also causes lytic infection in the oropharynx, controlled by the immune system. Uncontrolled lytic infection in the oropharynx is manifested as oral hairy leukoplakia in immunosuppressed hosts. Oral hairy leukoplakia is not associated with any malignant potential.

In 1992, the University of Connecticut School of Dental Medicine reported on two cases of oral hairy leukoplakia occurring in patients without any risk factors for HIV infection, or any other evidence of immune deficiency.^[2] It has been observed in patients on steroid therapy.^[3]

Treatment

The condition does not cause any other symptoms and does not require any treatment.^{[citation needed]} If treatment is required, acyclovir or valacyclovir is sometimes used.^[4]

See also

• List of cutaneous conditions

References

1. ^ James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0. 
2. ^ Eisenberg E, Krutchkoff D, Yamase H. (1992). "Incidental oral hairy leukoplakia in immunocompetent persons. A report of two cases.". Oral Surg Oral Med Oral Pathol. 74 (3): 332–3. doi:10.1016/0030-4220(92)90070-7. PMID 1328983. 
3. ^ Piperi E, Omlie J, Pambuccian S, Koutlas IG (November 2008). "Oral Hairy Leukoplakia in HIV-Negative Patients: Report of 10 Cases". Int. J. Surg. Pathol. 18 (3): 177–83. doi:10.1177/1066896908327865. PMID 19033322. http://ijs.sagepub.com/cgi/pmidlookup?view=long&pmid=19033322. 
4. ^ Walling DM, Flaitz CM, Nichols CM (September 2003). "Epstein-Barr virus replication in oral hairy leukoplakia: response, persistence, and resistance to treatment with valacyclovir". J. Infect. Dis. 188 (6): 883–90. doi:10.1086/378072. PMID 12964120. http://www.journals.uchicago.edu/cgi-bin/resolve?JID30686. 

External links

• Overview at tthhivclinic.com
• Clinical Trial at Memorial Sloan Kettering, NYC
• Clinical Trial at Memorial Sloan Kettering, NYC

This medical symptom article is a stub. You can help Wikipedia by expanding it.v · Categories: Oral pathology Conditions of the mucous membranes Symptom stubs Wikimedia Foundation. 2010. Игры ⚽ Поможем сделать НИР Alpine skiing at the 1998 Winter Olympics Air Nostrum Look at other dictionaries: hairy leukoplakia — n a condition that affects the mouth and esp. the edges of the tongue, is characterized by poorly demarcated white raised lesions with a corrugated appearance, is caused by infection with the Epstein Barr virus, and is associated with HIV… …   Medical dictionary oral hairy leukoplakia — n HAIRY LEUKOPLAKIA * * * hairy l …   Medical dictionary Leukoplakia — Classification and external resources The white lesion is an example of leukoplakia. ICD 10 K …   Wikipedia leukoplakia — A white patch of oral or female genital mucous membrane that cannot be wiped off and cannot be diagnosed clinically as any specific disease entity; in current usage, a clinical …   Medical dictionary leukoplakia — leucoplakia; n. a thickened white patch on a mucous membrane, such as the mouth lining or vulva, that cannot be rubbed off. It is not a specific disease and is present in about 1% of the elderly. Occasionally leukoplakia can become malignant.… …   The new mediacal dictionary leukoplakia — /looh keuh play kee euh/, n. Pathol. a disorder of a mucous membrane characterized by one or more white patches, occurring most commonly on the cheek, tongue, vulva, or penis: often medically insignificant but sometimes becoming malignant. Also,… …   Universalium List of cutaneous conditions — This is an incomplete list, which may never be able to satisfy particular standards for completeness. You can help by expanding it with reliably sourced entries. See also: Cutaneous conditions, Category:Cutaneous conditions, and ICD 10… …   Wikipedia Mumps — For other uses of the word Mumps or MUMPS, see Mumps (disambiguation). Mumps Classification and external resources Child with mumps. ICD 10 B …   Wikipedia Drooling — Classification and external resources ICD 10 K11.7 ICD 9 527.7 …   Wikipedia Acute necrotizing ulcerative gingivitis — This article is about the physiologic disorder. For the similarly named band, see Trenchmouth. Necrotizing ulcerative gingivitis/periodontitis Classification and external resources ICD 10 A69.1 ICD 9 …   Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”