Thermospray

Thermospray

Thermospray is a form of atmospheric pressure ionization in mass spectrometry. It transfers ions from the liquid phase to the gas phase for analysis. It is particularly useful in liquid chromatography-mass spectrometry. [Blakley, C. R.; Carmody, J. J.; Vestal, M. L. "Liquid Chromatograph-Mass Spectrometer for Analysis of Nonvolatile Samples" Analytical Chemistry 1980, 52, 1636-1641.] [ [http://dx.doi.org/10.1002/mas.1280110103 Combined liquid chromatography mass spectrometry. Part III. Applications of thermospray, Patrick Arpino, Mass Spectrometry Reviews, Vol 11, 1992 pp 3-40] ] cite journal |author=Gelpí E |title=Biomedical and biochemical applications of liquid chromatography-mass spectrometry |journal=Journal of chromatography. A |volume=703 |issue=1-2 |pages=59–80 |year=1995 |pmid=7599744 |doi=]

Ionization mechanism

TSP ionization is achieved by passing a pressurized solution through a heated tube which partially vaporizes the effluent to generate a spray prior to entering the ion source. Droplets from the spray contain a statistical imbalance of charges originating from charged solutes present in the solution. The droplets gradually decrease in size by evaporation of neutral solvent molecules until the droplet reaches a size at which the charge repulsion forces overcome the cohesive forces of the droplet.

ee also

*Electrospray
*Atmospheric pressure chemical ionization
*Thermal ionization
*Sonic spray ionization

References


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