Thiamylal


Thiamylal

drugbox
IUPAC_name = 5-pentan-2-yl-5-prop-2-enyl-2-sulfanylidene-1,3-diazinane-4,6-dione
synonyms = Thiamylal, Thioseconal, Surital


width = 100
CAS_number = 77-27-0
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PubChem = 3032285
DrugBank =
C = 12 | H = 18 | N = 2 | O = 2 | S = 1
molecular_weight = 254.35 g/mol
bioavailability =
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legal_CA = Schedule III
legal_UK =
legal_US = Schedule III
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Thiamylal (Surital) is a barbiturate derivative invented in the 1950s. It has sedative, anticonvulsant and hypnotic effects, and is used as a strong but short acting sedative. Thamylal is still in current use, primarily for induction in surgical anaesthesia [ Hsieh MY, Hung GY, Hsieh YL, Chang CY, Hwang B. Deep sedation with methohexital or thiamylal with midazolam for invasive procedures in children with acute lymphoblastic leukemia. Acta Paediatrica Taiwan. 2005 Sep-Oct;46(5):294-300. ] or as an anticonvulsant to counteract side effects from other anaesthetics. [ Tsai CJ, Wang HM, Lu IC, Tai CF, Wang LF, Soo LY, Lu DV. Seizure after local anesthesia for nasopharyngeal angiofibroma. Kaohsiung Journal of Medical Sciences. 2007 Feb;23(2):97-100. ] It is the Thiobarbiturate anologue of secobarbital.

References


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Look at other dictionaries:

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