Peptide sequence


Peptide sequence

Peptide sequence or amino acid sequence is the order in which amino acid residues, connected by peptide bonds, lie in the chain in peptides and proteins. The sequence is generally reported from the N-terminal end containing free amino group to the C-terminal end containing free carboxyl group. Peptide sequence is often called protein sequence if it represents the primary structure of a protein.

Sequence notation and applications

Many peptide sequences have been n sequence databases. These databases may use various notations to describe the peptide sequence. The full names of the amino acids are rarely given; instead, 3-letter or 1-letter abbreviations are usually recorded for conciseness.

Several deductions can be made from the sequence itself. Long stretches of hydrophobic residues may indicate transmembrane helices. These helices may indicate the peptide is a cell receptor. Certain residues indicate a beta sheet area. If full-length protein sequence is available, it is possible to estimate the isoelectric point of the protein. Methods for determining the peptide sequence include deduction from DNA sequence, Edman degradation, and mass spectrometry.

Techniques in sequence analysis can be applied to learn more about the peptide. These techniques generally consist of comparing the sequence to other sequences from sequence databases. Other sequences may have already been studied and determined to be significant. Findings about these sequences may be applicable to the sequence under investigation.

See also

* Protein
* Protein sequencing
* Rosetta@home
* SIMAP

External links

* [http://www.nslij-genetics.org/dnacorr/ A bibliography on features, patterns, correlations in DNA and protein texts]


Wikimedia Foundation. 2010.

Look at other dictionaries:

  • Peptide sequence tag — A peptide sequence tag is a piece of information about a peptide obtained by tandem mass spectrometry that can be used to identify this peptide in a protein database.cite journal |author=Hardouin J |title=Protein sequence information by matrix… …   Wikipedia

  • Peptide synthesis — In organic chemistry, peptide synthesis is the production of peptides, which are organic compounds in which multiple amino acids are linked via peptide bonds which are also known as amide bonds. The biological process of producing long peptides… …   Wikipedia

  • Sequence analysis — The term sequence analysis in biology implies subjecting a DNA or peptide sequence to sequence alignment, sequence databases, repeated sequence searches, or other bioinformatics methods on a computer.Sequence analysis in molecular biology and… …   Wikipedia

  • Peptide hormone — Peptide hormones are a class of peptides that are secreted into the blood stream and have endocrine functions in living animals. [ [http://books.google.com/books?id=hrp1AAAACAAJ Peptide Hormone Secretion/Peptide Hormone Action: A Practical… …   Wikipedia

  • Sequence signal — Séquence signal La séquence signal ou peptide signal est une chaine de 20 à 30 acides aminés qui destine la protéine synthétisée à un certain organite de la cellule. De manière imagée, on peut voir cette séquence signal comme le code postal du… …   Wikipédia en Français

  • Peptide mass fingerprinting — Citation maintenance. Please you see. Any concerns? Please . Peptide mass fingerprinting (PMF) (also known as protein fingerprinting) is an analytical technique for protein identification that was developed in 1993 by several groups independently …   Wikipedia

  • Peptide — Peptides redirects here. For the journal, see Peptides (journal). A tetrapeptide (example Val Gly Ser Ala) with green marked amino end (L Valine) and …   Wikipedia

  • Séquence signal — La séquence signal ou peptide signal est une chaîne de 20 à 30 acides aminés qui destine la protéine synthétisée à un certain organite de la cellule. De manière imagée, on peut voir cette séquence signal comme le code postal du destinataire.… …   Wikipédia en Français

  • peptide — A sequence of amino acids linked by peptide bonds; a breakdown or build up unit in protein metabolism. Typically used to describe low molecular weight species. See: polypeptide …   Glossary of Biotechnology

  • peptide — n. Biochem. any of a group of organic compounds consisting of two or more amino acids bonded in sequence. Etymology: G Peptid, back form. (as POLYPEPTIDE) …   Useful english dictionary


Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.