- Peptide sequence
Peptide sequence or amino acid sequence is the order in which
amino acidresidues, connected by peptide bonds, lie in the chain in peptides and proteins. The sequence is generally reported from the N-terminal end containing free amino groupto the C-terminal end containing free carboxyl group. Peptide sequence is often called protein sequence if it represents the primary structureof a protein.
Sequence notation and applications
Many peptide sequences have been n
sequence databases. These databases may use various notations to describe the peptide sequence. The full names of the amino acids are rarely given; instead, 3-letter or 1-letter abbreviations are usually recorded for conciseness.
Several deductions can be made from the sequence itself. Long stretches of
hydrophobicresidues may indicate transmembrane helices. These helices may indicate the peptide is a cell receptor. Certain residues indicate a beta sheetarea. If full-length protein sequence is available, it is possible to estimate the isoelectric pointof the protein. Methods for determining the peptide sequence include deduction from DNAsequence, Edman degradation, and mass spectrometry.
sequence analysiscan be applied to learn more about the peptide. These techniques generally consist of comparing the sequence to other sequences from sequence databases. Other sequences may have already been studied and determined to be significant. Findings about these sequences may be applicable to the sequence under investigation.
* [http://www.nslij-genetics.org/dnacorr/ A bibliography on features, patterns, correlations in DNA and protein texts]
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