Low density lipoprotein receptor-related protein 8

Low density lipoprotein receptor-related protein 8

Low density lipoprotein receptor-related protein 8, apolipoprotein e receptor, also known as LRP8, is a human gene.cite web | title = Entrez Gene: LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7804| accessdate = ]

Low density lipoprotein receptor-related protein 8, or LRP8 (also Apolipoprotein E Receptor 2; ApoER2) is a member of the LDL receptor family that plays a role in endocytosis and signal transduction. Together with VLDLR it is able to bind reelin, leading to the phosphorylation of DAB1, which binds on its cytosolic tail.

PBB_Summary
section_title =
summary_text = This gene encodes an apolipoprotein E receptor, a member of the low density lipoprotein receptor (LDLR) family. Apolipoprotein E is a small lipophilic plasma protein and a component of lipoproteins such as chylomicron remnants, very low density lipoprotein (VLDL), and high density lipoprotein (HDL). The apolipoprotein E receptor is involved in cellular recognition and internalization of these lipoproteins. Alternative splicing generates multiple transcript variants encoding distinct isoforms for this gene.cite web | title = Entrez Gene: LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7804| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Kim DH, Iijima H, Goto K, "et al." |title=Human apolipoprotein E receptor 2. A novel lipoprotein receptor of the low density lipoprotein receptor family predominantly expressed in brain. |journal=J. Biol. Chem. |volume=271 |issue= 14 |pages= 8373–80 |year= 1996 |pmid= 8626535 |doi=
*cite journal | author=Kim DH, Magoori K, Inoue TR, "et al." |title=Exon/intron organization, chromosome localization, alternative splicing, and transcription units of the human apolipoprotein E receptor 2 gene. |journal=J. Biol. Chem. |volume=272 |issue= 13 |pages= 8498–504 |year= 1997 |pmid= 9079678 |doi=
*cite journal | author=Clatworthy AE, Stockinger W, Christie RH, "et al." |title=Expression and alternate splicing of apolipoprotein E receptor 2 in brain. |journal=Neuroscience |volume=90 |issue= 3 |pages= 903–11 |year= 1999 |pmid= 10218790 |doi=
*cite journal | author=Sun XM, Soutar AK |title=Expression in vitro of alternatively spliced variants of the messenger RNA for human apolipoprotein E receptor-2 identified in human tissues by ribonuclease protection assays. |journal=Eur. J. Biochem. |volume=262 |issue= 1 |pages= 230–9 |year= 1999 |pmid= 10231386 |doi=
*cite journal | author=Trommsdorff M, Gotthardt M, Hiesberger T, "et al." |title=Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2. |journal=Cell |volume=97 |issue= 6 |pages= 689–701 |year= 1999 |pmid= 10380922 |doi=
*cite journal | author=Riddell DR, Vinogradov DV, Stannard AK, "et al." |title=Identification and characterization of LRP8 (apoER2) in human blood platelets. |journal=J. Lipid Res. |volume=40 |issue= 10 |pages= 1925–30 |year= 1999 |pmid= 10508213 |doi=
*cite journal | author=D'Arcangelo G, Homayouni R, Keshvara L, "et al." |title=Reelin is a ligand for lipoprotein receptors. |journal=Neuron |volume=24 |issue= 2 |pages= 471–9 |year= 1999 |pmid= 10571240 |doi=
*cite journal | author=Korschineck I, Ziegler S, Breuss J, "et al." |title=Identification of a novel exon in apolipoprotein E receptor 2 leading to alternatively spliced mRNAs found in cells of the vascular wall but not in neuronal tissue. |journal=J. Biol. Chem. |volume=276 |issue= 16 |pages= 13192–7 |year= 2001 |pmid= 11152697 |doi= 10.1074/jbc.M011795200
*cite journal | author=Riddell DR, Sun XM, Stannard AK, "et al." |title=Localization of apolipoprotein E receptor 2 to caveolae in the plasma membrane. |journal=J. Lipid Res. |volume=42 |issue= 6 |pages= 998–1002 |year= 2001 |pmid= 11369809 |doi=
*cite journal | author=Weeber EJ, Beffert U, Jones C, "et al." |title=Reelin and ApoE receptors cooperate to enhance hippocampal synaptic plasticity and learning. |journal=J. Biol. Chem. |volume=277 |issue= 42 |pages= 39944–52 |year= 2002 |pmid= 12167620 |doi= 10.1074/jbc.M205147200
*cite journal | author=Stockinger W, Sailler B, Strasser V, "et al." |title=The PX-domain protein SNX17 interacts with members of the LDL receptor family and modulates endocytosis of the LDL receptor. |journal=EMBO J. |volume=21 |issue= 16 |pages= 4259–67 |year= 2002 |pmid= 12169628 |doi=
*cite journal | author=Ma SL, Ng HK, Baum L, "et al." |title=Low-density lipoprotein receptor-related protein 8 (apolipoprotein E receptor 2) gene polymorphisms in Alzheimer's disease. |journal=Neurosci. Lett. |volume=332 |issue= 3 |pages= 216–8 |year= 2003 |pmid= 12399018 |doi=
*cite journal | author=Koch S, Strasser V, Hauser C, "et al." |title=A secreted soluble form of ApoE receptor 2 acts as a dominant-negative receptor and inhibits Reelin signaling. |journal=EMBO J. |volume=21 |issue= 22 |pages= 5996–6004 |year= 2003 |pmid= 12426372 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Sun XM, Soutar AK |title=The transmembrane domain and PXXP motifs of ApoE receptor 2 exclude it from carrying out clathrin-mediated endocytosis. |journal=J. Biol. Chem. |volume=278 |issue= 22 |pages= 19926–32 |year= 2003 |pmid= 12621059 |doi= 10.1074/jbc.M302047200
*cite journal | author=Benhayon D, Magdaleno S, Curran T |title=Binding of purified Reelin to ApoER2 and VLDLR mediates tyrosine phosphorylation of Disabled-1. |journal=Brain Res. Mol. Brain Res. |volume=112 |issue= 1-2 |pages= 33–45 |year= 2003 |pmid= 12670700 |doi=
*cite journal | author=Sacre SM, Stannard AK, Owen JS |title=Apolipoprotein E (apoE) isoforms differentially induce nitric oxide production in endothelial cells. |journal=FEBS Lett. |volume=540 |issue= 1-3 |pages= 181–7 |year= 2003 |pmid= 12681505 |doi=
*cite journal | author=Lutters BC, Derksen RH, Tekelenburg WL, "et al." |title=Dimers of beta 2-glycoprotein I increase platelet deposition to collagen via interaction with phospholipids and the apolipoprotein E receptor 2'. |journal=J. Biol. Chem. |volume=278 |issue= 36 |pages= 33831–8 |year= 2003 |pmid= 12807892 |doi= 10.1074/jbc.M212655200
*cite journal | author=Bajari TM, Strasser V, Nimpf J, Schneider WJ |title=A model for modulation of leptin activity by association with clusterin. |journal=FASEB J. |volume=17 |issue= 11 |pages= 1505–7 |year= 2003 |pmid= 12824284 |doi= 10.1096/fj.02-1106fje
*cite journal | author=May P, Bock HH, Nimpf J, Herz J |title=Differential glycosylation regulates processing of lipoprotein receptors by gamma-secretase. |journal=J. Biol. Chem. |volume=278 |issue= 39 |pages= 37386–92 |year= 2003 |pmid= 12871934 |doi= 10.1074/jbc.M305858200

External links

* [http://www.schizophreniaforum.org/new/detail.asp?id=1229 Are You Reelin in the Years? Not without Alternative Splicing]

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