- Waterhouse-Friderichsen syndrome
Name = Waterhouse-Friderichsen syndrome
DiseasesDB = 29316
ICD10 = ICD10|A|39|1|a|30, ICD10|E|35|1|e|20
ICD9 = ICD9|036.3
eMedicineSubj = med
eMedicineTopic = 3009
MeshID = D014884
Waterhouse-Friderichsen syndrome (WFS) is a disease of the
adrenal glands mostly commonly caused by the bacterium " Neisseria meningitidis". The infection leads to massive hemorrhageinto one or (usually) both adrenal glands.cite book | author = Kumar V, Abbas A, Fausto N | title = Robins and Coltran: Pathological Basis of Disease | edition = 7th | publisher = Elsevier | year = 2005 | pages = pp. 1214–5 | id = ISBN 978-0721601878] It is characterized by overwhelming bacterial infection meningococcemia, low blood pressure and shock, disseminated intravascular coagulation(DIC) with widespread purpura, and rapidly developing adrenocortical insufficiency.
"Meningococcus" is another term for the
bacterial species " Neisseria meningitidis", blood infection with which usually underlies WFS.
WFS can also be caused by "
Streptococcus pneumoniae" infections, a common bacterial pathogen typically associated with meningitis in the adult and elderly population. " Staphylococcus aureus" has recently also been implicated in pediatric WFS.cite journal |author=Adem P, Montgomery C, Husain A, Koogler T, Arangelovich V, Humilier M, Boyle-Vavra S, Daum R |title=Staphylococcus aureus sepsis and the Waterhouse-Friderichsen syndrome in children |journal=N Engl J Med |volume=353 |issue=12 |pages=1245–51 |year=2005 |pmid=16177250 |doi=10.1056/NEJMoa044194]
Routine vaccination against meningococcus is recommended for people who have poor splenic function (who, for example, have had their spleen removed or who have
sickle-cell diseasewhich damages the spleen), or who have certain immune disorders, such as a complement deficiency.cite journal |author=Rosa D, Pasqualotto A, de Quadros M, Prezzi S |title=Deficiency of the eighth component of complement associated with recurrent meningococcal meningitis--case report and literature review |journal=Braz J Infect Dis |volume=8 |issue=4 |pages=328–30 |year=2004 |pmid=15565265 |doi=10.1590/S1413-86702004000400010]
igns and symptoms
WFS is the most severe form of meningococcal septicemia. The onset of the illness is nonspecific with fever, rigors, vomiting, and headache. Soon a rash appears; first macular, not much different from the rose spots of typhoid, and rapidly becoming
petechial and purpuric with a dusky gray color. Low blood pressure ( hypotension) is the rule and rapidly leads to septic shock. The cyanosisof extremities can be impressive and the patient is very prostrated or comatose. In this form of meningococcal disease, meningitis generally does not occur. There is hypoglycemiawith hyponatremiaand hyperkalemia, and the ACTH stimulation testdemonstrates the acute adrenal failure. Leukocytosisneed not to be extreme and in fact leukopeniamay be seen and it is a very poor prognostic sign. C-reactive proteinlevels can be elevated or almost normal. Thrombocytopeniais sometimes extreme, with alteration in prothrombin time(PT) and partial thromboplastin time(PTT) suggestive of diffuse intravascular coagulation(DIC). Acidosis and acute renal failure can be seen as in any severe sepsis. Meningococci can be readily cultured from blood or CSF, and can sometimes be seen in smears of cutaneous lesions.
Fulminant meningococcemia is a medical emergency and need to be treated with adequate antibiotics as fast as possible.
Benzylpenicillinwas once the drug of choice with chloramphenicolas a good alternative in allergic patients. Ceftriaxoneis an antibiotic commonly employed today. Hydrocortisonecan sometimes reverse the hypoadrenal shock. Sometimes plastic surgery and grafting is needed to deal with tissue necrosis.
Waterhouse-Friderichsen syndrome is named after
Rupert Waterhouse(1873–1958), an English physician, and Carl Friderichsen(1886–1979), a Danish pediatrician, who wrote papers on the syndrome, which had been previously described.cite journal | author = Waterhouse R | title = A case of suprarenal apoplexy | journal = Lancet | year = 1911 | volume = 1 |pages = 577–8 | doi = 10.1016/S0140-6736(01)60988-7 ] cite journal | author = Friderichsen C | title = Nebennierenapoplexie bei kleinen Kindern | journal = Jahrb Kinderheilk | year = 1918 | volume = 87 | pages = 109–25 ]
* [http://www.whonamedit.com/synd.cfm/2187.html Whonamedit.com] page on the eponym
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Waterhouse-Friderichsen syndrome — Wa·ter·house Frid·er·ich·sen syndrome wȯt ər .hau̇s frid (ə )rik sən n acute and severe meningococcemia with hemorrhage into the adrenal glands Waterhouse Rupert (1873 1958) British physician , and Friderichsen Carl (1886 1979) Danish physician … Medical dictionary
Waterhouse-Friderichsen syndrome — ▪ pathology a rare type of septicemia (blood poisoning) of rapid and severe onset, marked by fever, collapse and sometimes coma, hemorrhage from skin and mucous membranes, and severe bilateral hemorrhage of the adrenal cortical tissue. The… … Universalium
Waterhouse-Friderichsen syndrome — noun syndrome associated with bacterial meningitis; marked by sudden high fever and skin discoloration and petechiae with hemorrhage into the adrenal glands and cardiovascular collapse • Hypernyms: ↑syndrome * * * ˈwȯ]d.ə(r)ˌhau̇ˈsfrid(ə)riksən … Useful english dictionary
Waterhouse-Friderichsen syndrome — acute haemorrhage in the adrenal glands with haemorrhage into the skin associated with the sudden onset of acute bacteraemic shock. It is usually caused by meningococcal septicaemia (see meningitis) [Waterhouse (1873–1958), British physician; C.… … The new mediacal dictionary
Синдром Уотерхаузафридериксена, Сепсис Молниеносный Менингококковый (Waterhouse-Friderichsen Syndrome) — очень остро протекающий сепсис с острыми кровоизлияниями в надпочечники, сопровождающимися подкожными кровоизлияниями и внезапным наступлением острого бактериального шока. Причиной развития данного состояния (чаще всего у детей ред.) обычно… … Медицинские термины
Waterhouse — may refer to:;Surname: * Agnes Waterhouse (c.1503 1566), first woman executed for witchcraft in England. * Alfred Waterhouse (1830–1905), English architect. * Benjamin Waterhouse (1754 1846), American physician. * Bill Waterhouse, Australian… … Wikipedia
Friderichsen-Waterhouse syndrome — Frid·er·ich·sen Wa·ter·house syndrome (fridґrik sən wawґtər hous) [Carl Friderichsen, Danish pediatrician, 20th century; Rupert Waterhouse, British physician, 1873â€“1958] Waterhouse Friderichsen syndrome … Medical dictionary
Friderichsen-Waterhouse syndrome — Waterhouse Friderichsen s … Medical dictionary
Syndrome du choc toxique — CIM 10 : A48.3 Le syndrome du choc toxique (SCT) est une maladie infectieuse rare et aiguë, potentiellement létale, causée par une toxine bactérienne qui pénètre dans la circulation sanguine suite à une infection par un agent pathogène.… … Wikipédia en Français
syndrome — The aggregate of symptoms and signs associated with any morbid process, and constituting together the picture of the disease. SEE ALSO: disease. [G. s., a running together, tumultuous concourse; (in med.) a concurrence of symptoms, fr. syn,… … Medical dictionary