Cediranib

Cediranib

drugbox
IUPAC_name = 4- [(4-fluoro-2-methyl-1"H"-indol-5-yl)oxy] -6-methoxy-
7- [3-(pyrrolidin-1-yl)propoxy] quinazoline



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C = 25 | H = 27 | F = 1 | N = 4 | O = 3
molecular_weight = 450.5 g/mol
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elimination_half-life = 12 to 35 hours
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routes_of_administration = Oral

Cediranib (tentative trade name Recentin), also known as AZD2171, is a potent inhibitor of vascular endothelial growth factor (VEGF) receptor tyrosine kinases. It is being developed by AstraZeneca as a possible chemotherapeutic agent for oral administration.

As of 2007, it is undergoing Phase I clinical trials for the treatment of non-small cell lung cancer and colorectal cancer in adults, as well as tumors of the central nervous system in children.

On February 27th, 2008, AstraZeneca announced that the use of Recentin in non-small cell lung cancer will not progress into phase III after failing to meet its main goal.

Further reading

*cite journal |author=Wedge S, Kendrew J, Hennequin L "et al". |title=AZD2171: a highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancer |journal=Cancer Res |volume=65 |issue=10 |pages=4389–400 |year=2005 |pmid=15899831 |doi=10.1158/0008-5472.CAN-04-4409

External links

* [http://www.cancerline.com/cancerlinehcp/15602_15632_9_3_1.aspx AZD2171—AstraZeneca Pipeline]


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