2-hydroxyphytanoyl-CoA lyase


2-hydroxyphytanoyl-CoA lyase

protein
Name=2-hydroxyacyl-CoA lyase 1
caption=


width=
HGNCid=17856
Symbol=HACL1
AltSymbols=HPCL
EntrezGene=26061
OMIM=604300
RefSeq=NM_012260
UniProt=Q9UJ83
PDB=
ECnumber=
Chromosome=3
Arm=p
Band=24.3
LocusSupplementaryData=

2-Hydroxyphytanoyl-CoA lyase is a peroxisomal enzyme involved in the catabolism of phytanoic acid. It requires thiamine diphosphate (ThDP) as cofactor. [cite journal |author=Foulon V, Antonenkov V, Croes K et al. |title=Purification, molecular cloning, and expression of 2-hydroxyphytanoyl-CoA lyase, a peroxisomal thiamine pyrophosphate-dependent enzyme that catalyzes the carbon-carbon bond cleavage during alpha-oxidation of 3-methyl-branched fatty acids |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue=18 |pages=10039–44 |year=1999 |pmid=10468558 |doi=10.1073/pnas.96.18.10039]

It is classified under EC number 4.1.

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