- Mycobacterium kansasii
Mycobacterium kansasii Scientific classification Kingdom: Bacteria Phylum: Actinobacteria Order: Actinomycetales Suborder: Corynebacterineae Family: Mycobacteriaceae Genus: Mycobacterium Species: M. kansasii Binomial name Mycobacterium kansasii
Hauduroy 1955, ATCC 12478
Mycobacterium kansasii is a bacterium in the Mycobacterium family. The genus includes species known to cause serious diseases in mammals, including tuberculosis and leprosy, but this species is generally not dangerous to healthy people.
Gram-positive, nonmotile, moderately long to long and acid-fast rods.
- Smooth to rough colonies after 7 or more days of incubation.
- Colonies grown in dark are nonpigmented, when grown in light or when young colonies are exposed briefly to light, colonies become brilliant yellow (photochromogenic).
- If grown in a lighted incubator, most strains form dark red crystals of β-carotene on the surface and inside of colony.
- Growth on Middlebrook 7H10 agar at 37°C within 7 days or more.
- Resistant to pyrazinamide.
- Susceptible to ethambutol.
- Closely related to the non-pathogenic, also slowly growing, nonpigmented, M. gastri.
- Both species share an identical 16S rDNA but differentiation is possible by differences in the ITS and hsp65 sequences
- A commercial hybridisation assay (AccuProbe) to identify M. kansasii exists.
- Chronic human pulmonary disease resembling tuberculosis (involvement of the upper lobe).
- Extrapulmonary infections, (cervical lymphadenitis in children, cutaneous and soft tissues infections and musculoskeletal system involvement), are uncommon.
- Rarely causes disseminated disease except in patients with severely impaired cellular immunity (patients with organ transplants or AIDS).
- Patients with silicosis are at risk.
- Also appears in patients with hairy cell leukemia, but not in other lymphoproliferative disorders.
- Mycobacterium kansasii occasionally involves the skin in a sporotrichoid pattern.:341
- Normally considered not to be contagious from person to person.
- Natural sources of infections unclear. Tap water is believed to be the major reservoir associated with human disease.
- Biosafety level 2
- First and most frequently isolated from human pulmonary secretions and lesions.
Strain ATCC 12478 = CIP 104589 = DSM 44162 = JCM 6379 = NCTC 13024.
- ^ Hauduroy,P. 1955. Derniers aspects du monde des mycobactéries. Masson et Cie, Paris, 1955.
- ^ Ryan KJ, Ray CG (editors) (2004). Sherris Medical Microbiology (4th ed. ed.). McGraw Hill. ISBN 0-8385-8529-9.
- ^ http://emedicine.medscape.com/article/223230-overview
- ^ Wintrobe, Maxwell Myer (2004). Wintrobe's clinical hematology. John G. Greer; John Foerster, John N. Lukens, George M Rodgers, Frixos Paraskevas (11 ed.). Hagerstown, MD: Lippincott Williams & Wilkins. pp. 2467. ISBN 0-7817-3650-1.
- ^ James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0.
Actinobacteria (high-G+C) Infectious diseases · Bacterial diseases: G+ (primarily A00–A79, 001–041, 080–109) Actinomycineae CorynebacterineaeTuberculosis: Ghon focus/Ghon's complex · Pott disease · brain (Meningitis, Rich focus) · Tuberculous lymphadenitis (Tuberculous cervical lymphadenitis) · cutaneous (Scrofuloderma, Erythema induratum, Lupus vulgaris, Prosector's wart, Tuberculosis cutis orificialis, Tuberculous cellulitis, Tuberculous gumma) · Lichen scrofulosorum · Tuberculid (Papulonecrotic tuberculid) · Primary inoculation tuberculosis · Miliary · Tuberculous pericarditis · Urogenital tuberculosis · Multi-drug-resistant tuberculosis · Extensively drug-resistant tuberculosis BifidobacteriaceaeGardnerella vaginalis Slowly growing
R3N=nonchromogenic)Long helix 18
(TKHGC)M. tuberculosis groupK/H groupsM. kansasii groupM. haemophilum groupM. conspicuum groupR2S (M. conspicuum)Long helix 18
(other)M. xenopi groupM. celatum groupM. hiberniae groupShort helix 18M. intermedium groupUngrouped
Runyon IVM. neoaurum groupF/T groupsM. fortuitum groupM. vaccae groupM. smegmatis groupM. chelonae groupM. elephantis group
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