Dihydrofolic acid

Dihydrofolic acid
IUPAC name N-(4-{[(2-amino-4-oxo-1,4,7,8-tetrahydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
Other names H2folate, DH
Identifiers
CAS number	4033-27-6
PubChem	98792
ChemSpider	89228 Y
MeSH	dihydrofolate
ChEBI	CHEBI:15633 Y
ChEMBL	CHEMBL46294 Y
Jmol-3D images	Image 1
SMILES O=C(O)[C@@H](NC(=O)c1ccc(cc1)NCC/2=N/C=3C(=O)\N=C(/NC=3NC\2)N)CCC(=O)O
InChI InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/t12-/m0/s1 Y Key: OZRNSSUDZOLUSN-LBPRGKRZSA-N Y InChI=1/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/t12-/m0/s1 Key: OZRNSSUDZOLUSN-LBPRGKRZBB
Properties
Molecular formula	C19H21N7O6
Molar mass	443.414 g/mol
Y acid (verify) (what is: Y/N?) Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Dihydrofolic acid is a folic acid derivative acted upon by dihydrofolate reductase to produce tetrahydrofolic acid. Since tetrahydrofolate is needed to make both purines and pyrimidines, dihydrofolate reductase is targeted by various drugs to prevent nucleic acid synthesis. Dihydrofolic acid is also known by the name dihydrofolate - more commonly vitamin B₉.

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective Wikipedia articles. ^[1]

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Fluorouracil (5-FU) Activity edit

References

1. ^ The interactive pathway map can be edited at WikiPathways: "FluoropyrimidineActivity_WP1601". http://www.wikipathways.org/index.php/Pathway:WP1601. 

This article about an organic compound is a stub. You can help Wikipedia by expanding it.v · Categories: Folates Organic compound stubs Wikimedia Foundation. 2010. Игры ⚽ Поможем сделать НИР Tetrahydrofolic acid Building (magazine) Look at other dictionaries: dihydrofolic acid — di·hy·dro·fol·ic ac·id (di hi″dro foґlik) any of the folic acids in which the bicyclic pteridine structure is in the dihydro, partially reduced form; they are intermediates in folate metabolism and are reduced to their tetrahydro, reduced… …   Medical dictionary 7,8-dihydrofolic acid — Intermediate between folic acid and 5,6,7,8 tetrahydrofolic acid, oxidation of the latter requiring NADP+ and dehydrofolate reductase …   Medical dictionary Folic acid — Folic acid …   Wikipedia Ascorbic acid — This article is about the molecular aspects of ascorbic acid. For information about its role in nutrition, see Vitamin C. L Ascorbic acid …   Wikipedia Dehydroascorbic acid — IUPAC name (5R) 5 [(1S) 1,2 dihydroxyethyl]furan 2,3,4(5H) trione …   Wikipedia Folic acid — One of the B vitamins that is a key factor in the synthesis (the making) of nucleic acid (DNA and RNA). A deficiency of folic acid after birth causes a kind of anemia, namely, megaloblastic anemia in which there is a paucity of red blood cells… …   Medical dictionary Levomefolic acid — IUPAC name (2S) 2 [ [4 [(2 Amino 5 methyl 4 oxo 1,6,7,8 tetrahydropteridin 6 yl) methylamino]benzoyl] …   Wikipedia Tetrahydrofolic acid — Chembox new ImageFile = Tetrahydrofolic acid.svg ImageSize = 250px IUPACName = OtherNames = Section1 = Chembox Identifiers CASNo = 29347 89 5 PubChem = 1129 SMILES = MeSHName = 5,6,7,8 tetrahydrofolic+acid Section2 = Chembox Properties Formula =… …   Wikipedia Primidone — Systematic (IUPAC) name 5 ethyl 5 phenyl hexahydropyrimidine 4,6 dione Clinical data Pregnancy cat. D …   Wikipedia Dihydrofolate reductase — Ribbon diagram of human dihydrofolate reductase in complex with folate (blue). From PDB 1DRF …   Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”