Tetrahydrofolic acid

Tetrahydrofolic acid

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ImageFile = Tetrahydrofolic acid.svg
ImageSize = 250px
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Section1 = Chembox Identifiers
CASNo = 29347-89-5
PubChem = 1129
MeSHName = 5,6,7,8-tetrahydrofolic+acid

Section2 = Chembox Properties
Formula = C19H23N7O6
MolarMass = 445.43 g/mol
Appearance =
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Section3 = Chembox Hazards
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Tetrahydrofolic acid is a folic acid derivative.


Human synthesis

It is produced from dihydrofolic acid by dihydrofolate reductase. This reaction is inhibited by methotrexate.

It is converted into 5,10-methylenetetrahydrofolate by serine hydroxymethyltransferase.

Bacterial synthesis

Many bacteria use dihydropteroate synthetase to produce dihydropteroate in bacteria, an enzyme without function in humans. This makes it a useful target for sulfonamide antibiotics, which compete with the PABA precursor.


It is a coenzyme in many reactions, especially in the metabolism of amino acids and nucleic acids. It acts as a donor of a group with one carbon atom. It gets this carbon atom by sequestering formaldehyde produced in other processes. A shortage in THF can cause anemia.

Tetrahydrofolic acid is reduced by the drug methotrexate, which is used to impair nucleotide synthesis. This drug is a potent chemotherapy and anti rheumatic.

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