3-hydroxy-3-methylglutaryl-CoA lyase


3-hydroxy-3-methylglutaryl-CoA lyase

protein
Name = 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (hydroxymethylglutaricaciduria)
caption =


width =
HGNCid = 5005
Symbol = HMGCL
AltSymbols =
EntrezGene = 3155
OMIM = 246450
RefSeq = NM_000191
UniProt = P35914
PDB =
ECnumber = 4.1.3.4
Chromosome = 1
Arm = p
Band = 36.1
LocusSupplementaryData = -p35
3-hydroxy-3-methylglutaryl-CoA lyase (or HMG-CoA lyase) plays an essential role in breaking down dietary proteins and fats for energy.

Specifically, the enzyme is responsible for processing the amino acid leucine.

Pathology

Mutations in the "HMGCL" gene cause 3-hydroxy-3-methylglutaryl-CoA lyase deficiency.

External links

*


Wikimedia Foundation. 2010.

Look at other dictionaries:

  • 3-hydroxy-3-methylglutaryl-CoA lyase deficiency — Infobox Disease Name = PAGENAME Caption = HMG CoA DiseasesDB = 29826 ICD10 = ICD9 = ICDO = OMIM = 246450 MedlinePlus = eMedicineSubj = eMedicineTopic = MeshID = C0080473 hydroxy 3 methylglutaryl CoA lyase deficiency also referred to as HMG CoA… …   Wikipedia

  • β-hydroxy-β-methylglutaryl-CoA — A key intermediate in the synthesis of ketone bodies, of steroids, and of farnesyl and geranyl derivatives. SYN: 3 hydroxy 3 methylglutaryl CoA. β hydroxy β methylglutaryl lyase an enzyme, found primarily in liver and rumen epithelium that… …   Medical dictionary

  • Hydroxymethylglutaryl-CoA-Lyase — Modellstruktur der menschlichen HMG CoA Lyase nach …   Deutsch Wikipedia

  • HMG-CoA-Lyase — Vorhandene Strukturdaten: 2cw6 …   Deutsch Wikipedia

  • hydroxymethylglutaryl-CoA lyase — hy·droxy·meth·yl·glu·ta·ryl CoA ly·ase (hi drok″se meth″əl glooґtə rəl ko aґ liґās) [EC 4.1.3.4] an enzyme of the lyase class that catalyzes the cleavage of 3 hydroxy 3 methylglutaryl CoA to form acetyl coenzyme A… …   Medical dictionary

  • Methylcrotonyl-CoA carboxylase — methylcrotonoyl Coenzyme A carboxylase 1 (alpha) Identifiers Symbol MCCC1 Entrez 56922 HUGO …   Wikipedia

  • Cystathionine gamma-lyase — Cysteine metabolism. Cystathionase catalyzes the lower reaction. Identifiers EC number …   Wikipedia

  • Propionyl-CoA carboxylase — PCCA redirects here. For other uses, see PCCA (disambiguation). Propionyl CoA carboxylase Identifiers EC number 6.4.1.3 CAS number …   Wikipedia

  • Methylmalonyl-CoA mutase — Rendering based on PDB 2XIJ …   Wikipedia

  • Methylmalonyl CoA epimerase — Ribbon diagram of methylmalonyl CoA epimerase from Propionibacterium shermanii. From PDB 1JC5 …   Wikipedia


Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.