Chromogranin

Chromogranin

protein
Name=chromogranin A (parathyroid secretory protein 1)
caption=


width=
HGNCid=1929
Symbol=CHGA
AltSymbols=
EntrezGene=1113
OMIM=118910
RefSeq=NM_001275
UniProt=P10645
PDB=
ECnumber=
Chromosome=14
Arm=q
Band=32
LocusSupplementaryData=protein
Name=chromogranin B (secretogranin 1)
caption=


width=
HGNCid=1930
Symbol=CHGB
AltSymbols=SCG1
EntrezGene=1114
OMIM=118920
RefSeq=NM_001819
UniProt=P05060
PDB=
ECnumber=
Chromosome=20
Arm=pter
Band=
LocusSupplementaryData=-p12protein
Name=secretogranin II (chromogranin C)
caption=


width=
HGNCid=10575
Symbol=SCG2
AltSymbols=
EntrezGene=7857
OMIM=118930
RefSeq=NM_003469
UniProt=P13521
PDB=
ECnumber=
Chromosome=2
Arm=q
Band=35
LocusSupplementaryData=-q36The chromogranin/secretogranin (granins) are a family of regulated secretory proteins ubiquitously found in the cores of amine and peptide hormone and neurotransmitter dense-core secretory vesicles,cite journal | author = Huttner WB, Gerdes HH, Rosa P | title = The granin (chromogranin/secretogranin) family | journal = Trends Biochem. Sci. | volume = 16 | issue = 1 | pages = 27–30 | year = 1991 | month = January | pmid = 2053134 | doi = | url = | issn = ] and consist of several independent proteins:

* chromogranin A (CgA)
* chromogranin B (CgB)
* secretogranin II (SgII) (see also secretoneurin)

Four other proteins (secretogranin III-VI) are also proposed to belong to the granins on the basis of their physico-chemical properties.

Granins function as pro-hormones, giving rise to an array of peptide fragments for which autocrine, paracrine, and endocrine activities have been demonstrated in vitro and in vivo.

The intracellular biochemistry of granins includes binding of Ca2+, ATP and catecholamines (epinephrine, norepinephrine) within the hormone storage vesicle core.

There is evidence that CgA, and perhaps other granins, regulate the biogenesis of dense-core secretory vesicles in neuroendocrine cells.

References

External links

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Look at other dictionaries:

  • Chromogranin A — (parathyroid secretory protein 1) Identifiers Symbols CHGA; CGA External IDs …   Wikipedia

  • Chromogranin — Chromogranine (eng. chromogranins) bezeichnen eine Gruppe saurer Proteine, die zuerst in Vesikeln von Adrenalin und Noradrenalin produzierenden Zellen des Nebennierenmarks gefunden wurden und die zusammen mit ATP (siehe Nucleotide) und… …   Deutsch Wikipedia

  • chromogranin — noun Any of a family of secretory proteins found in many types of cell …   Wiktionary

  • chromogranin — chro·mo·gran·in (kro″mo granґin) any of a group of acidic polypeptides that are the major soluble protein constituents of the secretory granules of the chromaffin cells of the adrenal medulla; they are also widely distributed in endocrine… …   Medical dictionary

  • CHGA — chromogranin A …   Medical dictionary

  • CHGB — chromogranin B …   Medical dictionary

  • CHGA — • chromogranin A …   Dictionary of medical acronyms & abbreviations

  • CHGB — • chromogranin B …   Dictionary of medical acronyms & abbreviations

  • Secretoneurin — Secretoneurin, also called Chromogranin B (CHGB), is a 33 amino acid neuropeptide derived from secretogranin II (chromogranin C, CHGC) . Because of this secretogranin II is also called secretoneurin included (SN, included). PBB Summary section… …   Wikipedia

  • Granin — This article is about the protein family. For other uses of Granin, see Granin (disambiguation). Granin (chromogranin or secretogranin) Structure of SS cyclized catestatin fragment from chromogranin A.[1] …   Wikipedia

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