Nicotinamide adenine dinucleotide phosphate


Nicotinamide adenine dinucleotide phosphate
Nicotinamide adenine dinucleotide phosphate
Identifiers
CAS number 53-59-8 YesY
PubChem 5885
ChemSpider 5674 YesY
MeSH NADP
ChEBI CHEBI:44409 YesY
ChEMBL CHEMBL213053 N
Jmol-3D images Image 1
Properties
Molecular formula C21H29N7O17P3
Molar mass 744.413
 N adenine dinucleotide phosphate (verify) (what is: YesY/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Nicotinamide adenine dinucleotide phosphate, abbreviated NADP+ or TPN in older notation (triphosphopyridine nucleotide), is a coenzyme used in anabolic reactions, such as lipid and nucleic acid synthesis, which require NADPH as a reducing agent.

NADPH is the reduced form of NADP+. NADP+ differs from NAD+ in the presence of an additional phosphate group on the 2' position of the ribose ring that carries the adenine moiety.

Contents

In plants

In chlorophyll, NADP is added by ferredoxin-NADP+ reductase in the last step of the electron chain of the light reactions of Photosynthesis. The NADPH produced is then used as reducing power for the biosynthetic reactions in the Calvin Cycle of photosynthesis. In its energized state, it is NADPH, now holding an extra electron. It is used primarily to create the proton gradient in chloroplasts during the light-dependent reactions.

In animals

The oxidative phase of the pentose phosphate pathway is the major source of NADPH in cells, producing approximately 60% of the NADPH required.

NADPH provides the reducing equivalents for biosynthetic reactions and the oxidation-reduction involved in protecting against the toxicity of ROS (reactive oxygen species), allowing the regeneration of GSH (reduced glutathione). NADPH is also used for anabolic pathways, such as lipid synthesis, cholesterol synthesis, and fatty acid chain elongation.

The NADPH system is also responsible for generating free radicals in immune cells. These radicals are used to destroy pathogens in a process termed the respiratory burst.[1]

It is the source of reducing equivalents for cytochrome P450 hydroxylation of aromatic compounds, steroids, alcohols, and drugs.

Ball-and-stick models of NADP+ and NADPH
NADP+
NADP+  
NADPH
NADPH 

See also

References

  1. ^ . PMID 18950479. 

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Look at other dictionaries:

  • Nicotinamide Adénine Dinucléotide Phosphate — Général No CAS 53 59 8 …   Wikipédia en Français

  • Nicotinamide adenine dinucleotide phosphate — Nicotinamide adénine dinucléotide phosphate Nicotinamide adénine dinucléotide phosphate Général No CAS 53 59 8 …   Wikipédia en Français

  • Nicotinamide adénine dinucléotide phosphate — Général No CAS 53 59 8 …   Wikipédia en Français

  • nicotinamide adénine dinucléotide phosphate — ● nicotinamide adénine dinucléotide phosphate nom masculin Substance dérivée de l acide nicotinique comme le NAD, mais comportant en plus un radical phosphate, et qui intervient dans de nombreuses réactions métaboliques consommant de l énergie,… …   Encyclopédie Universelle

  • nicotinamide adenine dinucleotide phosphate — A coenzyme of many oxidases (dehydrogenases), in which the reaction NADP+ + 2H ⇋ NADPH + H+ takes place; the third phosphoric group esterifies the 2′ hydroxyl of the adenosine moiety of NAD+. * * * nicotinamide adenine dinucleotide phosphate n …   Medical dictionary

  • nicotinamide-adenine-dinucleotide phosphate — nikotinamidadenindinukleotido fosfatas statusas T sritis chemija apibrėžtis Kofermentas. santrumpa( os) NADP atitikmenys: angl. nicotinamide adenine dinucleotide phosphate rus. никотинамидадениндинуклеотидфосфат …   Chemijos terminų aiškinamasis žodynas

  • nicotinamide adenine dinucleotide phosphate — noun a coenzyme similar to NAD and present in most living cells but serves as a reductant in different metabolic processes • Syn: ↑NADP • Hypernyms: ↑coenzyme * * * noun : triphosphopyridine nucleotide * * * Biochem. See NADP [1960 65] …   Useful english dictionary

  • nicotinamide adenine dinucleotide phosphate — noun The phosphate of nicotinamide adenine dinucleotide; a coenzyme important in fatty acid synthesis …   Wiktionary

  • nicotinamide adenine dinucleotide phosphate — noun Date: 1963 NADP …   New Collegiate Dictionary

  • nicotinamide adenine dinucleotide phosphate — (NADP1; nik o tin ah maīd) An electron carrying coenzyme that most often participates as an electron carrier in biosynthetic metabolism …   Dictionary of microbiology