CAMP receptor protein

CAMP receptor protein

Protein
Name=PAGENAME


caption=Structure of the "E. coli" Cyclic AMP Receptor Protein.
Symbol=CRP
AltSymbols=CAP
EntrezGene=289905
RefSeq=NP_289905
UniProt=P0ACK0
PDB=1I5Z

cAMP receptor protein (in short CRP, also known as catabolite gene activator protein (in short CAP)) is a regulatory protein in bacteria. This protein binds cAMP, which causes a conformational change that allows the protein to bind tightly to a specific DNA sequence in the promoters of the genes it controls. [cite journal |author=Harman JG |title=Allosteric regulation of the cAMP receptor protein |journal=Biochim. Biophys. Acta |volume=1547 |issue=1 |pages=1–17 |year=2001 |pmid=11343786] The genes regulated by this protein are mostly involved in energy metabolism, such as galactose, citrate, or the PEP group translocation system. [cite journal |author=Weickert MJ, Adhya S |title=The galactose regulon of Escherichia coli |journal=Mol. Microbiol. |volume=10 |issue=2 |pages=245–51 |year=1993 |pmid=7934815 |doi=10.1111/j.1365-2958.1993.tb01950.x] [cite journal |author=Bott M |title=Anaerobic citrate metabolism and its regulation in enterobacteria |journal=Arch. Microbiol. |volume=167 |issue=2-3 |pages=78–88 |year=1997 |pmid=9133329 |doi=10.1007/s002030050419]

References

External links

[http://www.mun.ca/biochem/courses/4103/topics/CRP.html crystal structure of CRP and binding site properties]


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