Tertiary hydrogen bond

Tertiary hydrogen bond

Hydrogen bonding interaction in proteins plays a crucial role in protein folding, dynamics and function. A few percent of hydrogen bonds connect distant amino acid residues and are not involved in secondary structure stabilization. These hydrogen bonds have special role in the proteins and called tertiary hydrogen bonds cite journal|author= Bikadi Z, Demko L, Hazai E| title=Functional and structural characterization of a protein based on analysis of its hydrogen bonding network by hydrogen bonding plot| journal=Arch Biochem Biophys.|date=2007| volume=461 |issue=2 |pages=225–234 |doi=10.1016/j.abb.2007.02.020] . Tertiary hydrogen bonds can be viewed as a network enabling fast and specific (directional) communication over the whole protein.

Definition

# Hydrogen bonds that stabilize the tertiary structure of the proteins
# Off-diagonal points in the HB plot

ee also

Secondary hydrogen bond

HB Plot

Protein Structure

References


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