BCR gene


BCR gene

The BCR gene is one of the two genes in the bcr-abl complex, which is associated with the Philadelphia chromosome.

Pathology

A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene. [cite web | title = Entrez Gene: BCR breakpoint cluster region| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=613| accessdate = ]

ee also

* Abl gene

External links

*

References

Further reading

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citations =
*cite journal | author=Wang L, Seale J, Woodcock BE, Clark RE |title=e19a2-positive chronic myeloid leukaemia with BCR exon e16-deleted transcripts. |journal=Leukemia |volume=16 |issue= 8 |pages= 1562–3 |year= 2002 |pmid= 12145699 |doi= 10.1038/sj.leu.2402600

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