Zambrano is may refer to:


* Carlos Zambrano (born 1981), Major League Baseball starting pitcher for the Chicago Cubs
* Carlos Augusto Zambrano (born 1989), Peruvian Footballer playing for Schalke 04
* Eduardo Zambrano (born 1966), former Major League Baseball player
* Hazel Zambrano, (born 1976), physiotherapist and college lecturer from Dipolog City for the Dipolog Medical Centre Foundation College, Inc
* Kim Zambrano, fictional FDNY paramedic from "Third Watch"
* Lorenzo Zambrano (born 1945), Mexican businessman
* María Zambrano (1904–1991), Spanish essayist and philosopher
* Mateo de Toro y Zambrano (1727–1811), Chilean Viscount and later full count
* Octavio Zambrano (born 1958), football (soccer) coach
* Víctor Zambrano (born 1975), Major League Baseball pitcher for the New York Yankees


* Zambrano, Bolívar

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