- Z curve
The Z curve (or Z-curve) method is a
bioinformatics algorithm forgenome analysis. The Z-curve is a three-dimensionalcurve that constitutes a unique representation of aDNA sequence, i.e., for the Z-curve and the givenDNA sequence each can be uniquely reconstructed from the other. [cite journal
author = Zhang CT, Zhang R, Ou HY
year = 2003
title = The Z curve database: a graphic representation of genome sequences
journal = Bioinformatics
volume = 19
issue = 5
pages = 593–99
url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=12651717&query_hl=2&itool=pubmed_DocSum
accessdate=2007-01-26
doi = 10.1093/bioinformatics/btg041] The resulting curve has a zigzag shape, hence the name Z-curve. The Z-curve method has been used in many different areas ofgenome research, such asreplication origin identification, [cite journal
author = Zhang R, Zhang CT
year = 2005
title = Identification of replication origins in archaeal genomes based on the Z-curve method
journal = Archaea
volume = 1
issue = 5
pages = 335–46
url = http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=15876567&query_hl=2&itool=pubmed_docsum
accessdate=2007-01-26] "ab initio"gene prediction , [cite journal
author = Guo FB, Ou HY, Zhang CT
year = 2003
title = ZCURVE: a new system for recognizing protein-coding genes in bacterial and archaeal genomes
journal =Nucleic Acids Research
volume = 31
issue =
pages = 1780–89
url = http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=12626720&query_hl=2&itool=pubmed_DocSum
accessdate=2007-01-26
doi = 10.1093/nar/gkg254]isochore identification, [cite journal
author = Zhang CT, Zhang R
year = 2004
title = Isochore structures in the mouse genome
journal = Genomics
volume = 83
issue = 3
pages = 384–94
url = http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=14962664&query_hl=2&itool=pubmed_docsum
accessdate=2007-01-26
doi = 10.1016/j.ygeno.2003.09.011]genomic island identification [cite journal
author = Zhang R, Zhang CT
year = 2004
title = A systematic method to identify genomic islands and its applications in analyzing the genomes of Corynebacterium glutamicum and Vibrio vulnificus CMCP6 chromosome I
journal = Bioinformatics
volume = 20
issue = 5
pages = 612–22
url = http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=15033867&query_hl=2&itool=pubmed_docsum
accessdate=2007-01-26
doi = 10.1093/bioinformatics/btg453] andcomparative genomics . [cite journal
author = Zhang R, Zhang CT
year = 2003
title = Identification of genomic islands in the genome of Bacillus cereus by comparative analysis with Bacillus anthracis
journal = Physiological Genomics
volume = 16
issue =
pages = 19–23
url = http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=14600214&query_hl=2&itool=pubmed_docsum
accessdate=2007-01-26
doi = 10.1152/physiolgenomics.00170.2003]References
External links
* [http://tubic.tju.edu.cn/zcurve/ The Z curve database]
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