Fixed Dose Procedure


Fixed Dose Procedure

Fixed Dose Procedure (FDP), proposed in 1984, is a method to assess a substance's acute oral toxicity. [cite journal |author=Walum E |title=Acute oral toxicity |journal=Environ. Health Perspect. |volume=106 Suppl 2 |pages=497–503 |year=1998 |pmid=9599698 |url=http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=1533392&blobtype=pdf |doi=10.2307/3433801] In comparison to older LD50 test developed in 1927, this procedure produces accurate, reproducible results using fewer animals and causing less pain and suffering. [cite journal |author=van den Heuvel MJ, Clark DG, Fielder RJ, "et al" |title=The international validation of a fixed-dose procedure as an alternative to the classical LD50 test |journal=Food Chem. Toxicol. |volume=28 |issue=7 |pages=469–82 |year=1990 |pmid=2210519 |doi=10.1016/0278-6915(90)90117-6] This test is therefore one of the replacements for the LD50 test that is recommended by the Organisation for Economic Co-operation and Development.

FDP uses about 10 to 20 animals to find the dose producing toxicity signs but not death, and from there predicts the lethal dose. LD50 ("lethal dose 50%") uses about 60 to 80 animals to find a dose killing 50% of animals within a given time. FDP sometimes requires retesting using slightly higher or lower doses.

References

External links

* [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7598991&dopt=Abstract Department of Applied Statistics, University of Reading, UK.]


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