Fixed Dose Procedure

Fixed Dose Procedure

Fixed Dose Procedure (FDP), proposed in 1984, is a method to assess a substance's acute oral toxicity. [cite journal |author=Walum E |title=Acute oral toxicity |journal=Environ. Health Perspect. |volume=106 Suppl 2 |pages=497–503 |year=1998 |pmid=9599698 |url= |doi=10.2307/3433801] In comparison to older LD50 test developed in 1927, this procedure produces accurate, reproducible results using fewer animals and causing less pain and suffering. [cite journal |author=van den Heuvel MJ, Clark DG, Fielder RJ, "et al" |title=The international validation of a fixed-dose procedure as an alternative to the classical LD50 test |journal=Food Chem. Toxicol. |volume=28 |issue=7 |pages=469–82 |year=1990 |pmid=2210519 |doi=10.1016/0278-6915(90)90117-6] This test is therefore one of the replacements for the LD50 test that is recommended by the Organisation for Economic Co-operation and Development.

FDP uses about 10 to 20 animals to find the dose producing toxicity signs but not death, and from there predicts the lethal dose. LD50 ("lethal dose 50%") uses about 60 to 80 animals to find a dose killing 50% of animals within a given time. FDP sometimes requires retesting using slightly higher or lower doses.


External links

* [ Department of Applied Statistics, University of Reading, UK.]

Wikimedia Foundation. 2010.

Look at other dictionaries:

  • Median lethal dose — This article is about the toxicological term. For the album by Mudvayne, see L.D. 50 (album). For other uses, see LD50 (disambiguation). In toxicology, the median lethal dose, LD50 (abbreviation for “Lethal Dose, 50%”), LC50 (Lethal Concentration …   Wikipedia

  • Animal testing — A white Wistar lab rat Description Around 50–100 million vertebrate animals are used in experiments annually. Subjects Animal testing, scien …   Wikipedia

  • Poison — This article is about the type of substance. For other uses, see Poison (disambiguation). The EU s standard toxic symbol, as defined by Directive 67/548/EEC. The skull and crossbones has long been a standard symbol for poison. In the context of… …   Wikipedia

  • Protein adulteration in the People's Republic of China — refers to the adulteration and contamination of several food and feed ingredients with inexpensive melamine and other compounds such as cyanuric acid, ammeline and ammelide. These adulterants can be used to inflate the apparent protein content of …   Wikipedia

  • Biological warfare — For the use of biological agents by terrorists, see bioterrorism. Weapons of mass destruction …   Wikipedia

  • Activated carbon — Activated carbon, also called activated charcoal, activated coal or carbo activatus, is a form of carbon that has been processed to make it extremely porous and thus to have a very large surface area available for adsorption or chemical reactions …   Wikipedia

  • Toxicology — (from the Greek words τοξικός toxicos poisonous and logos) is a branch of biology, chemistry, and medicine concerned with the study of the adverse effects of chemicals on living organisms.[1] It is the study of symptoms, mechanisms, treatments… …   Wikipedia

  • Hazard symbol — The skull and crossbones, a common symbol for poison and other sources of lethal danger. Danger of death redirects here. For other uses, see Near death (disambiguation). Hazard symbols are recognizable symbols designed to warn about hazardous… …   Wikipedia

  • Toxicology testing — Toxicology testing, also known as safety testing, is conducted by pharmaceutical companies testing drugs, or by contract animal testing facilities such as Huntingdon Life Sciences and Inveresk Research International on behalf of a wide variety of …   Wikipedia

  • Mutagen — In genetics, a mutagen (Latin, literally origin of change) is a physical or chemical agent that changes the genetic material, usually DNA, of an organism and thus increases the frequency of mutations above the natural background level. As many… …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.